Bedaquiline, Antituberculosis/SARS-CoV2 3CLpro inhibitor

Product Details

Formal Name: (1R,2S)-1-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-naphthalen-1-yl-1-phenylbutan-2-ol

Alternate Names: TMC207; R207910

Molecular Formula: C₃₂H₃₁BrN₂O₂

Formula Weight: 555.50

CAS Number: 843663-66-1

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 10 mg/ml)

Storage: RT

Stability: ≥ 1 year.

Applications

Antituberculosis/SARS-CoV2 3CLpro inhibitor

Functions

Clinically useful antituberculosis agent that is active (MIC’s 0.030 to 0.120 µg/mL) against multi-drug resistant strains. It interferes with mycobacterial energy metabolism via binding to the oligomeric subunit c (AtpE) and subunit ε of ATP synthase inhibiting ATP production. Bedaquiline has recently been found to be an inhibitor (IC50 = 18.7 µM) of the SARS-CoV-2 main protease, 3CLpro.

Application Procedures

First dissolved in DMSO (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.

Research use only.

Documents

• Datasheet (PDF)