BADGE, PPARg antagonist

Product Details

Formal Name: 2,3-Bis[4-(2,3-epoxypropoxy)phenyl]propane

Alternate Names: Bisphenol A diglycidyl ether

Molecular Formula: C₂₁H₂₄O₄

Formula Weight: 340.41

CAS Number: 1675-54-3

Purity: >95%

Formulation: powder

Solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

PPARg antagonist

Functions

PPARγ antagonist with μM affinity in 3T3-L1 and 3T3-F442A preadipocyte cells. Selective over PPARδ and PPARα. Antagonizes the ability of rosiglitazone to stimulate transcriptional activity of PPARγ and abolishes its anti-inflammatory effects in a mouse model. Induces apoptosis via PPARγ-independent mechanisms. Induces adipogenesis in human and mouse mesenchymal stromal stem cells and in mouse 3T3-L1 preadipocytes at low nM concentrations via a PPARγ independent mechanism. Increases osteoblastogenesis and bone mass in a mouse model. Active in vivo.

Application Procedures

First dissolved in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Research use only.

Documents

• Datasheet (PDF)