B/B Homodimerizer

The B/B Homodimerizer is a membrane-permeant ligand that causes homodimerization of proteins fused to dimerization domain B (DmrB)-provided in the iDimerize Inducible Homodimer System (Cat. No. 635068). NOTE: The B/B Homodimerizer is identical to the AP20187 ligand previously supplied in the ARGENT Regulated Homodimerization Kit from ARIAD Pharmaceuticals, Inc.

Features

• Previously available from ARIAD as the ARGENT Regulated Homodimerization Kit
• Rapid chemical induction of cell signaling pathways
• Activate any pathway or cellular event controlled by homo-oligomers (e.g., dimers, trimers, or tetramers)
• Established tool used by over 2,000 research groups, with over 400 scientific publications to date
• B/B Homodimerizer is identical to the AP20187 ligand

Applications

Product citations Burnett, S. H. et al. Conditional macrophage ablation in transgenic mice expressing a Fas-based suicide gene. J. Leukoc. Biol. 75, 612–623 (2004). Freeman, K. W. et al. Inducible prostate intraepithelial neoplasia with reversible hyperplasia in conditional FGFR1-expressing mice. Ca

Documents

• Safety Data Sheet (PDF)
• User Manual (PDF)
• B/B Homodimerizer Components List
• Components
• Components