Solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 2 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
ERK inhibitor
Functions
AZD6244 is a potent, selective, and non-ATP competitive inhibitor of MEK1/2 (IC50 MEK1 = 14 nM) and ERK 1/2 phosphorylation (IC50 = 10 nM). AZD 6244 is in clinical trials for treating various cancers.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml) or in Ethanol (up to 2 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or Ethanol may be stored at -20°C for up to 2 months.
