Solubility: Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
GRAMD1A inhibitor
Functions
Inhibitor of autophagy (autophagy induced by amino acid starvation IC50 = 270 nM; Rapamycin IC50 = 140 nM) acting via selective targeting of the cholesterol transfer protein GRAM domain-containing protein 1A (GRAMD1A). Autogramin-2 inhibition of GRAMD1A inhibits biogenesis of the autophagosome.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml) or in Ethanol (25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
