Ascomycin, FKBP ligand; immunosupressant

Product Details

Formal Name: Fermentation product from Streptomyces hygroscopicus

Alternate Names: FK-520; FR-900520

Molecular Formula: C₄₃H₆₉NO₁₂

Formula Weight: 729.03

CAS Number: 104987-12-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 50 mg/ml), or in Ethanol (up to 50 mg/ml with warming).

Storage: -20°C

Stability: ≥ 2 years.

Applications

FKBP ligand; immunosupressant

Functions

Analog of FK-506. Potent immunosuppressant. Binds to FKBP12 and inhibits calcineurin and NFAT.  Displays antiinflammatory effects in skin diseases. Cell permeable and active in vivo.

Application Procedures

First dissolved in DMSO (up to 50 mg/ml), or in Ethanol (up to 50 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)