AS-60524, PI 3-Kinase inhibitor

Product Details

Formal Name: 5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione

Molecular Formula: C₁₂H₇N₃O₂S

Formula Weight: 257.27

CAS Number: 648450-29-7

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 1.5 m g/ml with warming)

Storage: -20°C

Stability: ≥ 2 years.

Applications

PI 3-Kinase inhibitor

Functions

Potent and selective inhibitor of PI 3-kinase γ (PI 3-Kγ ), IC50 = 8 nM displaying 30-fold selectivity over PI 3-Kδ and PI 3-Kβ and 7.5-fold selectivity over PI 3-Kα. Suppresses joint inflammation in two distinct mouse models. Ameliorates surgical brain injury, colitis, intimal hyperplasia-induced inflammatory processes and renal injury/fibrosis in rodent models. Orally active.

Application Procedures

First dissolved in DMSO (up to 1.5 m g/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)