Anle138b, Protein aggregation inhibitor

Product Details

Formal Name: 5-(1,3-Benzodioxol-5-yl)-3-(3-bromophenyl)-1H-pyrazole

Molecular Formula: C₁₆H₁₁BrN₂O₂

Formula Weight: 343.18

CAS Number: 882697-00-9

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 15 mg/ml with warming)

Storage: -20°C

Stability: ≥ 1 year.

Applications

Protein aggregation inhibitor

Functions

Aggregation inhibitor that modulates the formation of pathological oligomers of both prion and α-synuclein.1 In mouse models of prion and diseases and Parkinson’s disease, Anle138b strongly inhibited oligomer formation, neuronal degeneration, and disease progression even after disease onset. Anle138b has delayed disease progression and prevented motor decline in multiple neurodegenerative models. Treatment of melanoma cells with anle138b caused massive cell death via major dysregulation of autophagy revealing a protective effect of α-synuclein on autophagy in these cells. Orally bioavailable and able to cross the blood-brain barrier.

Application Procedures

First dissolved in DMSO (up to 15 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)