AM-580, Retinoid RARα agonist

Product Details

Formal Name: 4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido]benzoic acid

Alternate Names: CD336; NSC 608001; Ro 40-6055

Molecular Formula: C₂₂H₂₅NO₃

Formula Weight: 351.40

CAS Number: 102121-60-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (35 mg/ml); or Ethanol (18 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Retinoid RARα agonist

Functions

A retinoic acid analog acting as a RARα agonist (Kd = 8 nM). Induces or blocks differentiation depending on cell type and environment. In combination with CHIR-99021 it induces differentiation of human induced pluripotent stem cells (iPSCs) into intermediate mesoderm (80% induction rate in 5 days) capable of forming kidney structures. AM-580 exhibits anti-angiogenic activity in vivo, and induces differentiation of acute promyelocytic leukemia cells.

Application Procedures

First dissolved in DMSO (35 mg/ml); or Ethanol (18 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)