AG-879, NGFR kinase inhibitor

Product Details

Formal Name: 3,5-Di-t-butyl-4-hydroxybenzylidene cyanothioacetamide

Molecular Formula: C₁₈H₂₄N₂OS

Formula Weight: 316.47

CAS Number: 148741-30-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

NGFR kinase inhibitor

Functions

Inhibits NGF-induced neurite growth in PC12 cells via selective inhibition of NGF receptor(pp140c-trk) autophosphorylation (IC50 = 10 µM).   No inhibition of EGF, or PDGF receptor phosphorylation at typical working concentrations.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)