AG-1517 HCl, EGFR Tyrosine kinase inhibitor

Product Details

Formal Name: 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline hydrochloride

Alternate Names: PD153,053; SU-5271; Z-252868

Molecular Formula: C₁₆H₁₄BrN₃O₂

Formula Weight: 360.21

CAS Number: 153436-54-5

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 5 mg/ml).

Storage: RT

Stability: ≥ 1 year.

Applications

EGFR Tyrosine kinase inhibitor

Functions

An ultra-potent inhibitor of epidermal growth factor receptor tyrosine kinase (EGFRK), with an IC50 of 25 pM. Inhibits other tyrosine kinases at micromolar or higher concentrations. It selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation. Inhibits the growth of a number of cancer cell lines. An extremely useful tool for exploring EGF-mediated cellular signaling.

Application Procedures

First dissolved in DMSO (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)