Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 6 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
TrkB agonist/neurotrophic
Functions
A selective TrkB agonist (Kd=320 nM) with potent neurotrophic activity. Significantly improves motor deficits, ameliorates brain atrophy and extends survival in the well-characterized N171-82Q Huntington’s disease mouse model. Post-traumatic brain injury-treatment promotes neurogenesis in the hippocampus in a mouse model. Improves motor performance and motor neuronal survival in an ALS mouse model.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 6 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 week.
