Solubility: Soluble in DMSO (up to 15 mg/ml), or in Ethanol (up to 4 mg/ml with warming).
Storage: -20°C
Stability: ≥ 1 year.
Applications
GSK-3 inhibitor
Functions
Potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3) IC50=5 nM. The first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells. Promotes proliferation in mammalian cardiomyocytes A potent inhibitor of malignant lymphoid cell proliferation.
Application Procedures
First dissolved in DMSO (up to 15 mg/ml), or in Ethanol (up to 4 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
