Inhibits glutathione reductase and thioredoxin reductase, IC50s=6.7 and 8.7 µM respectively, and impairs mitochondrial function. May be used to induce a cellular model of thiol oxidative stress. Enhances sensitivity of cancer cell lines to X-ray irradiation. Induces G2/M cell cycle arrest by inducing thiol oxidative stress resulting in α-tubulin S-glutathionylation-mediated microtubule depolymerization. Improves limb revascularization by glutathionylation and subsequent stabilization of HIF-1α.
Application Procedures
First dissolved in DMSO up to 50 mg/ml, then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
