1,4-DPCA, Prolyl hydroxylase inhibitor

Product Details

Formal Name: 1,4-Dihydrophenonthrolin-4-one-3-carboxylic acid

Molecular Formula: C₁₃H₈N₂O₃

Formula Weight: 240.22

CAS Number: 331830-20-7

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 15 mg/ml with warming)

Storage: RT

Stability: ≥ 2 years.

Applications

Prolyl hydroxylase inhibitor

Functions

Potent inhibitor of prolyl 4-hydroxylase (IC50=2-4 μM). Inhibits collagen deposition via inhibition of collagen proline hydroxylation. Subcutaneous injection of a 1,4-DPCA containing hydrogel into Swiss Webster mice that do not show a regenerative phenotype increased expression of HIF1α over 5 days. Multiple injections led to regenerative wound healing after ear hole punch injury.

Application Procedures

First dissolved in DMSO (up to 15 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 2 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)