{"product_id":"wyatt-dawn-8-multi-angle-light-scattering-detector","title":"DAWN 8 Multi-Angle Light Scattering Detector","description":"\u003cspan\u003e\u003cp align=\"center\"\u003e\u003cimg fetchpriority=\"high\" src=\"https:\/\/www.wyatt.com\/wp-content\/uploads\/2019\/10\/DAWN-Hero-Neon-9-19.jpg\" width=\"55%\"\u003e\u003c\/p\u003e\u003c\/span\u003e\n\u003cbr\u003e\n\u003cp\u003eThe world's most advanced light scattering instrument for absolute characterization of proteins, conjugates, macromolecules, and nanoparticles.\u003c\/p\u003e\n\u003cp\u003ePremier MALS\u003c\/p\u003e\n\u003cp\u003eThe DAWN instrument is the premier Multi-Angle static Light Scattering (MALS) detector for absolute characterization of the molar mass and size of macromolecules and nanoparticles in solution. It offers the highest sensitivity, the widest range of molecular weight, size, and concentration, and the largest selection of configurations and optional modules for enhanced capabilities.\u003c\/p\u003e\n\u003chr class=\"no_line\" style=\"margin: 0 auto 10px auto\"\u003e\n\u003cp\u003eSeparation First\u003c\/p\u003e\n\u003cp\u003eMALS is most often used in conjunction with a separation system such as Gel Permeation Chromatography (GPC-MALS), Size Exclusion Chromatography (SEC-MALS), or Field-Flow Fractionation (FFF-MALS) to determine distributions of mass, size, and composition, independent of column calibration by reference standards. \u003c\/p\u003e\n\u003chr class=\"no_line\" style=\"margin: 0 auto 10px auto\"\u003e\n\u003cp\u003eSupported by ASTRA\u003csup\u003e™\u003c\/sup\u003e Software\u003c\/p\u003e\nASTRA Software and its built-in analysis modules support the DAWN MALS instrument, providing the most versatile analysis available for online multi-angle and dynamic light scattering measurements. \n\u003cp\u003eOverview\u003c\/p\u003e\n\u003cp\u003eThe DAWN and its companion \u003ca href=\"https:\/\/www.wyatt.com\/products\/instruments\/optilab-refractive-index-detector.html\"\u003eOptilab\u003csup\u003e™\u003c\/sup\u003e\u003c\/a\u003e dRI detector are the established benchmarks for MALS analysis, cited in thousands of peer-reviewed publications. Multi-angle light scattering detection is indispensable for use with GPC and HPLC-SEC in order to obtain reliable molecular mass distributions and information on molecular conformation, branching ratio, fragments and aggregates.\u003c\/p\u003e\n\u003cp\u003eSEC-MALS with a DAWN and Optilab characterizes conformation and branching of \u003cb\u003esynthetic and natural polymers\u003c\/b\u003e larger than 10 nm in rms radius \u003ci\u003eR\u003c\/i\u003e\u003csub\u003eg\u003c\/sub\u003e. The addition of a \u003ca href=\"https:\/\/www.wyatt.com\/products\/instruments\/viscostar-online-differential-viscometer.html\"\u003eViscoStar\u003csup\u003e™\u003c\/sup\u003e\u003c\/a\u003e differential viscometer creates a GPC triple-detection system that can analyze molecular conformation and size below the \u003ci\u003eR\u003c\/i\u003e\u003csub\u003eg\u003c\/sub\u003e limit of 10 nm and determine Mark-Houwink Sakurada coefficients.\u003c\/p\u003e\n\u003cp\u003eThe combination of a UV\/Vis absorbance detector with a DAWN instrument and Optilab refractive index detector creates a UV-MALS-RI triple-detection system, for analysis of copolymers and protein conjugates (glycoproteins, PEGylated proteins, surfactant-bound membrane proteins, etc.). With the addition of a \u003ca href=\"https:\/\/store.wyatt.com\/shop\/udawn\/udawn3\/wiq\/\"\u003eWyattQELS\u003csup\u003e™\u003c\/sup\u003e DLS module\u003c\/a\u003e for size determination, protein conformation may be analyzed.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ci\u003eM\u003c\/i\u003e\u003csub\u003ew\u003c\/sub\u003e from 200 Da to 1000 MDa\u003c\/li\u003e\n\u003cli\u003eSensitivity: 10 ng\/mL 100 kDa polystyrene in THF, 0.4 µg\/mL BSA (66.4 kDa) in PBS\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ci\u003eR\u003c\/i\u003e\u003csub\u003eg\u003c\/sub\u003e from 10 to 500 nm, up to 1000 nm with shape-specific models\u003c\/li\u003e\n\u003cli\u003eUltra-stable, high-power laser\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThe DAWN may also be used in batch (off-line) mode to characterize the weight-average molar mass, z-average size \n  and second virial coefficient of unfractionated samples.\u003c\/p\u003e\n\u003cp\u003eIn conjunction with a \n  \u003ca href=\"https:\/\/www.wyatt.com\/products\/instruments\/calypso-ii-label-free-biomolecular-interactions.html\"\u003eCalypso\u003csup\u003e™\u003c\/sup\u003e   CG-MALS\u003c\/a\u003e system, the DAWN characterizes macromolecular interactions, label-free and immobilization-free: affinity and absolute stoichiometry of self- and hetero-association of simple or complex molecular systems. The Calypso system also automates the determination of second virial coefficients, cross virial coefficients, average molar masses and sizes.\u003c\/p\u003e\n\u003cp\u003eUltrasonic Cleaning Included\u003c\/p\u003e\n\u003cp\u003eEach DAWN instrument includes an embedded \u003ca href=\"https:\/\/www.wyatt.com\/accessories\/comet.html\"\u003e\u003cb\u003eCOMET\u003csup\u003e™\u003c\/sup\u003e\u003c\/b\u003e\u003c\/a\u003e ultrasonic transducer that cleans the flow cell automatically by agitating the fluid and loosening particles from the glass surfaces. \u003c\/p\u003e\n\u003cp\u003eTemperature-Controlled Models\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAmbient model\u003c\/li\u003e\n\u003cli\u003eUltra-High-Temperature (UHT) model, from ambient up to +210 °C\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003eStandard Peltier heated\/cooled (H\/C) model, temperature control from -15 °C to +150 °C\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eSpecifications\u003c\/h2\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMolar Mass Range\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e200 Da to 1 GDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMolecular Size Range ( R g )\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e≈ 10 to 500 nm, up to 1000 nm with shape-specific models\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMolecular Size Range ( R h )\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eIn flow mode, 0.5 nm to 300 nm ; batch mode 0.5 nm to 1 μm (requires WyattQELS DLS module or DynaPro NanoStar + fiber optic connection).\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSensitivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e10 ng of 100 kDa polystyrene in THF or 200 ng of BSA in PBS, assuming standard 7.8 mm x 300 mm SEC column and no post-column filter\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMobile Phase Compatibility\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eAll-solvent compatible (aqueous and organic). Wetted materials are 316 stainless steel, fused silica or F2 glass, and Kalrez.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMALS Detectors\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eHigh-gain, high dynamic range photodiodes at 18 detection angles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eAuxiliary Detectors\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eLaser monitor for stabilization feedback; forward transmission monitor to correct signals for absorbing samples and to assess data quality.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDynamic Range\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e3,300,000:1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDLS Detector (optional)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eWyattQELS dynamic light scattering module installs directly inside the DAWN chassis. Alternatively, the optical fiber pickup of the DynaPro NanoStar cuvette-based DLS instrument or Mobius DLS-ELS instrument may be installed in the DAWN.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eLaser Wavelength\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e658 nm ± 4 nm; 785 nm optional for use with fluorescing samples\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eLaser Power Control\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eProgrammable 10% to 100%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eFlow Cells\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eFused Silica, optimal for solvent refractive index less than 1.50; F2, optimal for solvent refractive index above 1.50\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eTemperature Options\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eAmbient Heated\/Cooled (HC) -15 °C to +150 °C Ultra-High-Temperature (UHT) ambient to +210 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eAnalog Inputs\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e4 differential analog inputs with 24 bit resolution. Input range -10 V to +10 V\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eAnalog Outputs\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e2 analog outputs from user selectable measurements channels -10 V to +10 V\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eOther Inputs\/Outputs\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eAlarm in, Alarm out\/retransmit, Auto-Inject in, Auto inject contact closure retransmit, Recycle In\/Out (operates Orbit recycle valve)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eComputer Interface\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eEthernet\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eFront Panel Display\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e10.1\" (257 mm), capacitive high-resolution screen with multi-touch functionality, displays signals, graphs, instrument settings and diagnostics\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDimensions\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e58 cm (L) x 36 cm (W) x 26 cm (H)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.wyatt.com\/products\/dawn-brochure-request.html\" target=\"_blank\"\u003eBrochure\u003c\/a\u003e\u003c\/p\u003e","brand":"Wyatt Technology","offers":[{"title":"Ambient \/ Fused Silica, 658 nm \/ None","offer_id":46488395481167,"sku":"WD38-016500","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica, 658 nm \/ WyattQELS","offer_id":46488407834703,"sku":"WD38-016501","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica, 658 nm \/ DLS Fiber","offer_id":46488407867471,"sku":"WD38-0165DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica, 785 nm \/ None","offer_id":46488407900239,"sku":"WD38-017800","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica, 785 nm \/ WyattQELS","offer_id":46488407933007,"sku":"WD38-017801","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica, 785 nm \/ DLS Fiber","offer_id":46488407965775,"sku":"WD38-0178DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica, Aqueous, 658 nm \/ None","offer_id":46488407998543,"sku":"WD38-01AQ6500","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica, Aqueous, 658 nm \/ WyattQELS","offer_id":46488408031311,"sku":"WD38-01AQ6501","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica, Aqueous, 658 nm \/ DLS Fiber","offer_id":46488408064079,"sku":"WD38-01AQ65DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica + Wide-Bore, 658 nm \/ WyattQELS","offer_id":46488408096847,"sku":"WD38-01036501","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica + Wide-Bore, 658 nm \/ DLS Fiber","offer_id":46488408129615,"sku":"WD38-010365DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Wide-Bore Fused Silica, 658 nm \/ WyattQELS","offer_id":46488408162383,"sku":"WD38-036501","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Wide-Bore Fused Silica, 658 nm \/ DLS Fiber","offer_id":46488408195151,"sku":"WD38-0365DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ 2 × Wide-Bore Fused Silica, 658 nm \/ WyattQELS","offer_id":46488408227919,"sku":"WD38-03036501","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ 2 × Wide-Bore Fused Silica, 658 nm \/ DLS Fiber","offer_id":46488408260687,"sku":"WD38-030365DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ To be specified \/ To be specified","offer_id":46488408293455,"sku":"WD38","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Heated\/Cooled \/ Fused Silica, 658 nm \/ None","offer_id":46488395513935,"sku":"WD3HC8-016500","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Heated\/Cooled \/ Fused Silica, 658 nm \/ WyattQELS","offer_id":46488408326223,"sku":"WD3HC8-016501","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Heated\/Cooled \/ Fused Silica, 658 nm \/ DLS Fiber","offer_id":46488408358991,"sku":"WD3HC8-0165DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Heated\/Cooled \/ To be specified \/ To be specified","offer_id":46488408391759,"sku":"WD3HC8","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Temperature Regulated \/ Fused Silica, 658 nm \/ None","offer_id":46488395546703,"sku":"WD3TR8-016500","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Temperature Regulated \/ Fused Silica, 658 nm \/ WyattQELS","offer_id":46488408424527,"sku":"WD3TR8-016501","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Temperature Regulated \/ Fused Silica, 658 nm \/ DLS Fiber","offer_id":46488408457295,"sku":"WD3TR8-0165DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Temperature Regulated \/ To be specified \/ To be specified","offer_id":46488408490063,"sku":"WD3TR8","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ultra-High Temperature \/ To be specified \/ To be specified","offer_id":46488408522831,"sku":"WD3UH8","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/DAWN-Hero-Neon-9-19_ec09b7e7-d1cb-4312-92a5-e60c5d7ceefb.jpg?v=1787675350","url":"https:\/\/www.danyel.co.il\/products\/wyatt-dawn-8-multi-angle-light-scattering-detector","provider":"danyel biotech","version":"1.0","type":"link"}