{"product_id":"sophia-ddm-extended-homologous-recombination-solution-exthrs-bs0128","title":"SOPHiA DDM™ Extended Homologous Recombination Solution (ExtHRS)","description":"\u003cp\u003eSOPHiA DDM™ ExtHRS is a sample-to-report NGS application that allows researchers to go further with their HRR mutation sequencing and identify the cause of HRD across cancer types, including ovarian, breast, prostate, colon, lung and pancreatic.\u003c\/p\u003e\u003cp\u003eSample-to-report bundle: capture-based target enrichment and library preparation kit combined with the analytical capabilities of the SOPHiA DDM™ Platform.\u003c\/p\u003e\u003ch2\u003eSpecifications\u003c\/h2\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eGene content\u003c\/th\u003e\n\u003ctd\u003e28 HRR-associated genes (26 targeted for CNV detection)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eDiseases covered\u003c\/th\u003e\n\u003ctd\u003eOvarian, breast, prostate, colon, lung and pancreatic cancers\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eDetected variants\u003c\/th\u003e\n\u003ctd\u003eSNVs\u003cbr\u003eIndels\u003cbr\u003eGene- and exon-level CNVs (incl. BRCA large genomic rearrangements)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSample type\u003c\/th\u003e\n\u003ctd\u003eFFPE, fresh-frozen tissue\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStarting material\u003c\/th\u003e\n\u003ctd\u003e50 ng DNA\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSamples per run\u003c\/th\u003e\n\u003ctd\u003eUp to 32 samples for Illumina® NextSeq® 500\/550 Mid Output Kit (also compatible with NovaSeq®, Element and MGI sequencers)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eReads per sample\u003c\/th\u003e\n\u003ctd\u003e8 million (2x150bp)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eLibrary preparation time\u003c\/th\u003e\n\u003ctd\u003e1.5 days\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eRegulatory status\u003c\/th\u003e\n\u003ctd\u003eResearch Use Only (RUO)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\u003ch2\u003eKey Features\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eExpand identification of HRD+ samples\u003c\/strong\u003e – Streamline your sample-to-report workflow with SOPHiA DDM™ for HRD. Leverage our flexible platform that offers a comprehensive range of guideline-driven and ready-to-use next generation sequencing (NGS)-based applications to enhance your HRD assessment capabilities.\u003c\/p\u003e\u003ch2\u003eWorkflow\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eEvery step leads to informed decisions\u003c\/strong\u003e – Empower your HRD expertise with a simple, adaptable workflow.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eA wave of insights for every laboratory\u003c\/strong\u003e – Streamline your blood cancer analysis workflow from sample to comprehensive, customized report.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlexible and scalable library preparation\u003c\/strong\u003e – Rely on robust sequencing across multiple applications using one universal and automated protocol.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAccurate variant detection and annotation\u003c\/strong\u003e – Precisely detect challenging genomic variants thanks to the power of our proprietary algorithms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCustomizable reporting\u003c\/strong\u003e – Quickly prepare comprehensive reports tailored to your needs.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eAnalytics\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eGive your HRD analysis a kick\u003c\/strong\u003e – Enhance your HRR mutation analysis and explore genomic instability with the advanced analytical capabilities and AI-driven algorithms of the SOPHiA DDM™ Platform.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eUniversal genomic integrity assessment\u003c\/strong\u003e – Apply deep learning-based analysis to low-pass WGS data (~1x coverage) in a decentralized workflow. The GIInger™ algorithm is designed to complement different capture-based BRCA workflows for a complete HRD assessment, with no impact on previous validation. GIInger™ demonstrated high analytical concordance to centralized reference methods for HRD assessment in ovarian cancer (92.91% overall percent agreement).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSensitive SNV and Indel detection\u003c\/strong\u003e – Accurately identify single nucleotide variants (SNVs) and small insertions\/deletions (Indels) in HRR genes associated with HRD. PEPPER™’s sophisticated algorithms differentiate true signal from noise, providing you with reliable results to guide your decisions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReliable CNV analysis\u003c\/strong\u003e – Identify critical gene amplification\/deletion and exon-level copy number variation (CNV) events associated with HRD status, including BRCA1\/2 or PTEN deletions and CCNE1 amplification. Our CNV calling algorithm adapts to experimental conditions and performs double normalization to call CNVs missed by other tools.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRobust variant annotation\u003c\/strong\u003e – Confidently interpret the clinical significance of genetic variants in HRD-associated cancers with MOKA™. Our annotation algorithm draws from curated databases and uses de novo predictions to assess the likely effects and pathogenicity of variants.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRecognized by ESMO guidelines\u003c\/strong\u003e – Considering the potential benefit of poly (ADP-ribose) polymerase inhibitor (PARPi) therapy, ESMO recommends carrying out BRCA1\/2 and HRD testing using a validated assay in patients with advanced ovarian cancer.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eDocuments\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/d3e30vlyff459p.cloudfront.net\/2b75c131-2c1d-4268-be32-67d15945dcb8\/b6d64e16-d9a3-42ed-8854-66c2426d0bb3\/b6d64e16-d9a3-42ed-8854-66c2426d0bb3_source__v.pdf\" target=\"_blank\" rel=\"noopener\"\u003eFlyer: SOPHiA DDM™ Extended Homologous Recombination Solution (ExtHRS) (RUO)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e\u003ch2\u003eOrdering Information\u003c\/h2\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eProduct code\u003c\/th\u003e\n\u003cth\u003eSequencer\u003c\/th\u003e\n\u003cth\u003eSample type\u003c\/th\u003e\n\u003cth\u003eReactions\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eBS0128ILLRSCY12-16\u003c\/td\u003e\n\u003ctd\u003eIllumina\u003c\/td\u003e\n\u003ctd\u003ecfDNA\u003c\/td\u003e\n\u003ctd\u003e16\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBS0128ILLRSCY12-32\u003c\/td\u003e\n\u003ctd\u003eIllumina\u003c\/td\u003e\n\u003ctd\u003ecfDNA\u003c\/td\u003e\n\u003ctd\u003e32\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBS0128ILLRSCY12-48\u003c\/td\u003e\n\u003ctd\u003eIllumina\u003c\/td\u003e\n\u003ctd\u003ecfDNA\u003c\/td\u003e\n\u003ctd\u003e48\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBS0128ILLRSMY10-16\u003c\/td\u003e\n\u003ctd\u003eIllumina\u003c\/td\u003e\n\u003ctd\u003eSomatic\u003c\/td\u003e\n\u003ctd\u003e16\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBS0128ILLRSMY10-32\u003c\/td\u003e\n\u003ctd\u003eIllumina\u003c\/td\u003e\n\u003ctd\u003eSomatic\u003c\/td\u003e\n\u003ctd\u003e32\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBS0128ILLRSMY10-48\u003c\/td\u003e\n\u003ctd\u003eIllumina\u003c\/td\u003e\n\u003ctd\u003eSomatic\u003c\/td\u003e\n\u003ctd\u003e48\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBS0128ILLRSMY10-96\u003c\/td\u003e\n\u003ctd\u003eIllumina\u003c\/td\u003e\n\u003ctd\u003eSomatic\u003c\/td\u003e\n\u003ctd\u003e96\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBS0128MGIRSCY12-32\u003c\/td\u003e\n\u003ctd\u003eMGI\u003c\/td\u003e\n\u003ctd\u003ecfDNA\u003c\/td\u003e\n\u003ctd\u003e32\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBS0128MGIRSCY12-48\u003c\/td\u003e\n\u003ctd\u003eMGI\u003c\/td\u003e\n\u003ctd\u003ecfDNA\u003c\/td\u003e\n\u003ctd\u003e48\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003e\u003cem\u003eFor Research Use Only. Not for use in diagnostic procedures.\u003c\/em\u003e\u003c\/p\u003e","brand":"SOPHiA GENETICS","offers":[{"title":"Illumina \/ 16 reactions \/ cfDNA","offer_id":46798538932303,"sku":"BS0128ILLRSCY12-16","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Illumina \/ 32 reactions \/ cfDNA","offer_id":46798538965071,"sku":"BS0128ILLRSCY12-32","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Illumina \/ 48 reactions \/ cfDNA","offer_id":46798538997839,"sku":"BS0128ILLRSCY12-48","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Illumina \/ 16 reactions \/ Somatic","offer_id":46798539030607,"sku":"BS0128ILLRSMY10-16","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Illumina \/ 32 reactions \/ Somatic","offer_id":46798539063375,"sku":"BS0128ILLRSMY10-32","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Illumina \/ 48 reactions \/ Somatic","offer_id":46798539096143,"sku":"BS0128ILLRSMY10-48","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Illumina \/ 96 reactions \/ Somatic","offer_id":46798539128911,"sku":"BS0128ILLRSMY10-96","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"MGI \/ 32 reactions \/ cfDNA","offer_id":46798539161679,"sku":"BS0128MGIRSCY12-32","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"MGI \/ 48 reactions \/ cfDNA","offer_id":46798539194447,"sku":"BS0128MGIRSCY12-48","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/sophia-genetics-logo.png?v=1789657266","url":"https:\/\/www.danyel.co.il\/products\/sophia-ddm-extended-homologous-recombination-solution-exthrs-bs0128","provider":"danyel biotech","version":"1.0","type":"link"}