{"product_id":"sophia-ddm-dx-solid-tumor-solution-ce-ivd-bs0105","title":"SOPHiA DDM™ Dx Solid Tumor Solution (CE-IVD)","description":"\u003cp\u003eSOPHiA DDM™ Dx Solid Tumor Solution is a CE-IVD application intended to identify variants occurring in 42 genes involved in solid tumors by targeting specific mutation-prone positions within the genomic sequence, as an aid to healthcare professionals to make a clinical decision related to solid tumors and to provide molecular rationale for appropriate therapy.\u003c\/p\u003e\u003cp\u003eSample-to-report bundle: capture-based target enrichment and library preparation kit combined with the analytical capabilities of the SOPHiA DDM™ Platform.\u003c\/p\u003e\u003ch2\u003eSpecifications\u003c\/h2\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eGene content\u003c\/th\u003e\n\u003ctd\u003e42 genes\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eDiseases covered\u003c\/th\u003e\n\u003ctd\u003eSolid tumors\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eDetected variants\u003c\/th\u003e\n\u003ctd\u003eSNVs and Indels in all genes of the panel\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSample type\u003c\/th\u003e\n\u003ctd\u003eFFPE\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStarting material\u003c\/th\u003e\n\u003ctd\u003e50 ng\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSequencer compatibility\u003c\/th\u003e\n\u003ctd\u003eIllumina® MiSeq™ (Reagent Kit v3)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSamples per run\u003c\/th\u003e\n\u003ctd\u003e24 for Illumina® MiSeq™ v3 (2x300bp)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eAnalysis time from FASTQ\u003c\/th\u003e\n\u003ctd\u003e\u0026lt; 4 hours\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eRegulatory status\u003c\/th\u003e\n\u003ctd\u003eCE-IVD\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\u003ch2\u003eKey Features\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eExpect more from your molecular analyses\u003c\/strong\u003e – Go from sample to report with targeted next-generation sequencing solutions for DNA and RNA analysis. Leverage our flexible platform that offers a comprehensive range of guideline-driven, ready-to-use, and customizable applications to enhance your solid tumor profiling capabilities.\u003c\/p\u003e\u003ch2\u003eWorkflow\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eScale your sequencing to new heights\u003c\/strong\u003e – Streamline your analysis with an accurate and adaptable targeted genomic profiling workflow.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlexible and scalable library preparation\u003c\/strong\u003e – Rely on robust sequencing across multiple applications using one universal and automated protocol.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAccurate variant detection and annotation\u003c\/strong\u003e – Precisely detect challenging genomic variants thanks to the power of our proprietary algorithms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCustomizable reporting\u003c\/strong\u003e – Quickly prepare comprehensive reports tailored to your needs.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eAnalytics\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eAdd flavor to your solid tumor analysis\u003c\/strong\u003e – Detect even the most challenging solid tumor biomarkers with the sophisticated algorithms of the SOPHiA DDM™ Platform.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSensitive SNV and Indel detection\u003c\/strong\u003e – Our sophisticated SNV and Indel calling algorithm implements relevant analytical modules that are tailored to reduce noise linked to sample type, sequencer, and library preparation. In an analysis of 150 FFPE samples, SOPHiA DDM™ Solid Tumor Solution (STS) demonstrated 98.8% sensitivity and 100% specificity for SNV\/Indel calling.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAccurate CNV calling\u003c\/strong\u003e – Our copy number variation (CNV) calling algorithm adapts to experimental conditions and performs double normalization to call CNVs missed by other tools. MUSKAT™ accurately detects and reports whole gene amplifications from solid tumors. Analysis results using SOPHiA DDM™ Solid Tumor Solution (STS) showed accurate detection of confirmed gene amplifications, including EGFR, KRAS, and ERBB2.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePartner-agnostic fusion calling\u003c\/strong\u003e – Our fusion calling technology accurately calls novel (partner-agnostic) fusions from DNA and RNA, utilizing a probabilistic graphical model to reduce false positives. In analyses of RNA and tNA reference and clinical samples, CARDAMOM demonstrated 100% sensitivity (84\/84 events, including 70\/70 in 66 clinical samples), detecting 7 events missed by an amplicon-based approach.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eUniversal genomic integrity assessment\u003c\/strong\u003e – Apply deep learning-based analysis to low-pass WGS data (~1x coverage) in a decentralized workflow. GIInger™ is designed to complement capture-based BRCA workflows for a complete HRD assessment, with no impact on previous validation. Beyond ovarian cancer, GIInger™ adapts universally across solid tumor applications, from targeted to CGP solutions. GIInger™ demonstrated high analytical concordance to centralized reference methods for HRD assessment in ovarian cancer (92.91% overall percent agreement).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePan-cancer MSI detection\u003c\/strong\u003e – Our microsatellite instability (MSI) technology relies on a powerful curve-fitting algorithm to better identify differences in the read length distribution of MSI and normal samples. MUSTARD™ demonstrated analytically accurate MSI detection in colorectal and endometrial cancer (100%), as well as in more challenging tumor types such as glioma (97.8%).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrecise molecular barcoding\u003c\/strong\u003e – SOPHiA DDM™ enables sensitive detection of relevant variants at low allele frequencies (down to 5% VAF for FFPE analysis). By incorporating our proprietary CUMIN™ molecular barcoding technology into sample preparation and leveraging our bioinformatic expertise, errors introduced during library preparation, target enrichment, or sequencing can be filtered out and true variant alleles identified.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRobust variant annotation\u003c\/strong\u003e – Our robust annotation algorithm retrieves information from curated databases and uses de novo analytics to provide insights on the likely effects and pathogenicity of genomic variants. Coupled with SOPHiA DDM™ filtering capabilities, our accurate variant annotation facilitates the identification of relevant variants.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIn-sync with ESMO guidelines\u003c\/strong\u003e – SOPHiA DDM™ for Solid Tumors – including SOPHiA DDM™ STS, SOPHiA DDM™ ROS and SOPHiA DDM™ STS+ – aligns with ESMO guidelines for NGS in advanced cancers, targeting tumor-agnostic biomarkers with an ESCAT Tier I score. It enables accurate detection of key genomic alterations, including NTRK fusions and BRAF mutations, across various cancers like non-small cell lung cancer (NSCLC) and breast cancer.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eDocuments\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/d3e30vlyff459p.cloudfront.net\/2b75c131-2c1d-4268-be32-67d15945dcb8\/f0ca068d-61d1-4965-b020-d5b11367803c\/f0ca068d-61d1-4965-b020-d5b11367803c_source__v.pdf\" target=\"_blank\" rel=\"noopener\"\u003eFact Sheet: SOPHiA DDM™ Dx Solid Tumor Solution (CE-IVD)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e\u003ch2\u003eOrdering Information\u003c\/h2\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eProduct code\u003c\/th\u003e\n\u003cth\u003eReactions\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eBS0105ILLCSML03-016\u003c\/td\u003e\n\u003ctd\u003e16\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBS0105ILLCSML03-032\u003c\/td\u003e\n\u003ctd\u003e32\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBS0105ILLCSML03-048\u003c\/td\u003e\n\u003ctd\u003e48\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003e\u003cem\u003eCE-IVD marked product for In Vitro Diagnostic use. Availability and regulatory status may differ by country - please contact us for the product information that applies to your laboratory.\u003c\/em\u003e\u003c\/p\u003e","brand":"SOPHiA GENETICS","offers":[{"title":"16 reactions","offer_id":46798537588815,"sku":"BS0105ILLCSML03-016","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"32 reactions","offer_id":46798537621583,"sku":"BS0105ILLCSML03-032","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"48 reactions","offer_id":46798537654351,"sku":"BS0105ILLCSML03-048","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/sophia-genetics-logo.png?v=1789657266","url":"https:\/\/www.danyel.co.il\/products\/sophia-ddm-dx-solid-tumor-solution-ce-ivd-bs0105","provider":"danyel biotech","version":"1.0","type":"link"}