{"product_id":"sophia-ddm-community-extended-pharmacogenomics-solution-extpgx-cs2587","title":"SOPHiA DDM™ Community Extended Pharmacogenomics Solution (ExtPGx)","description":"\u003cp\u003eSOPHiA DDM™ Community Extended Pharmacogenomics Solution combines a capture-based target enrichment kit with the analytical capabilities of the SOPHiA DDM™ Platform, covering 74 genes including a pseudogene, HLA and mtDNA, with star-allele calling.\u003c\/p\u003e\u003cp\u003eSample-to-report bundle: capture-based target enrichment and library preparation kit combined with the analytical capabilities of the SOPHiA DDM™ Platform.\u003c\/p\u003e\u003ch2\u003eSpecifications\u003c\/h2\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eGene content\u003c\/th\u003e\n\u003ctd\u003e74 genes including a pseudogene, HLA, and mtDNA coverage\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eDiseases covered\u003c\/th\u003e\n\u003ctd\u003eOncology, cardiovascular diseases, psychiatric disorders, pain management, infectious diseases, epilepsy, gastrointestinal diseases\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eDetected variants\u003c\/th\u003e\n\u003ctd\u003eSNVs, Indels, CNVs, star alleles (15 genes), CYP2D6\/CYP2D7 gene conversion\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSample type\u003c\/th\u003e\n\u003ctd\u003eBlood\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStarting material\u003c\/th\u003e\n\u003ctd\u003e50 ng DNA\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eTarget region size\u003c\/th\u003e\n\u003ctd\u003e260 kb\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSamples per run\u003c\/th\u003e\n\u003ctd\u003e12, 24, and 48 for Illumina Miseq™ i100 25M, 50M, and 100M flowcell\u003cbr\u003e12 for Illumina MiSeq® v3\u003cbr\u003e48 and 192 for Illumina NextSeq™ 500\/550 Mid- and High-Output Kits\u003cbr\u003e48, 192, 576, and 864 for Illumina NextSeq™ 1000\/2000 P1, P2, P3, and P4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eReads per sample\u003c\/th\u003e\n\u003ctd\u003e4 million\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eRegulatory status\u003c\/th\u003e\n\u003ctd\u003eResearch Use Only (RUO)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eLibrary prep and capture hands-on time + FASTQ analysis time\u003c\/th\u003e\n\u003ctd\u003e5 hours + 3 hours\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\u003ch2\u003eEmbrace the next generation of pharmacogenomic analysis\u003c\/h2\u003e\u003cp\u003eUnlock the future of precision medicine with cutting-edge SOPHiA DDM ™ technology powering NGS workflows, delivering unparalleled accuracy and ease.\u003c\/p\u003e\u003cp\u003eOur pharmacogenomics applications were developed in collaboration with leading PGx experts to encompass CPIC and FDA recommendations. They quickly and accurately identify PGx-associated genomic variants of clinical significance, powered by the advanced analytics of the SOPHiA DDM™ Platform.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAccurate CNV detection\u003c\/strong\u003e – CNVs are accurately detected by our MUSKAT ™ algorithm alongside SNVs and Indels in a single experiment capable of detecting known and previously undetected variants.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eA universal, scalable solution\u003c\/strong\u003e – Our decentralized, technology-agnostic application is compatible with a broad spectrum of laboratory equipment such as liquid handlers for automated library prep.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eEfficient star allele calling\u003c\/strong\u003e – Major haplotypes (star alleles) for VIP genes according to PharmVar and PharmGKB are assigned and annotated with phenotypic consequences by our AI agent, STAR ANISE.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eComprehensive output files\u003c\/strong\u003e – Pharmacogenomics-specific output files include the full variant table, star allele results, phenotype information, quality metrics, alignment, and genotyping of selected variants in the Sample Check ID file.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eRobust CYP2D6 assessment\u003c\/strong\u003e – CNVs, star alleles, and promoters\/UTRs in CYP2D6 are accurately called, including information for CYP2D6\/CYP2D7 pseudogene analysis.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAdvanced analytical performance\u003c\/strong\u003e – Extensive expertise in probe design and data science ensures high sensitivity, specificity, on-target rates, and coverage uniformity.\u003c\/p\u003e\u003ch2\u003eStreamline your PGx variant detection and analysis workflow\u003c\/h2\u003e\u003cp\u003eBoost lab efficiency with an end-to-end pharmacogenomics NGS workflow. Perform next-generation sequencing in house, or leverage SOPHiA DDM ™ Integrated Access Mode to tap into a global network of sequencing labs. All variant detection and interpretation steps are powered by the SOPHiA DDM ™ Platform, giving you full control over your data and samples.\u003c\/p\u003e\u003ch2\u003eDocuments\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3e30vlyff459p.cloudfront.net\/2b75c131-2c1d-4268-be32-67d15945dcb8\/70155006-29db-4a60-a836-f297cf112e2a\/70155006-29db-4a60-a836-f297cf112e2a_source__v.pdf\" target=\"_blank\" rel=\"noopener\"\u003eFact Sheet: Community ExtPGx Solution Fact Sheet\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3e30vlyff459p.cloudfront.net\/2b75c131-2c1d-4268-be32-67d15945dcb8\/aacbc71a-f91b-4d1c-9e50-525bef54d587\/aacbc71a-f91b-4d1c-9e50-525bef54d587_source__v.pdf\" target=\"_blank\" rel=\"noopener\"\u003eFlyer: SOPHiA DDM™ Pharmacogenomic Solutions\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eOrdering Information\u003c\/h2\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eProduct code\u003c\/th\u003e\n\u003cth\u003eReactions\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eCS2587ILLRGLY10-16\u003c\/td\u003e\n\u003ctd\u003e16\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCS2587ILLRGLY10-32\u003c\/td\u003e\n\u003ctd\u003e32\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCS2587ILLRGLY10-48\u003c\/td\u003e\n\u003ctd\u003e48\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCS2587ILLRGLY10-96\u003c\/td\u003e\n\u003ctd\u003e96\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003e\u003cem\u003eFor Research Use Only. Not for use in diagnostic procedures.\u003c\/em\u003e\u003c\/p\u003e","brand":"SOPHiA GENETICS","offers":[{"title":"16 reactions","offer_id":46798544961615,"sku":"CS2587ILLRGLY10-16","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"32 reactions","offer_id":46798544994383,"sku":"CS2587ILLRGLY10-32","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"48 reactions","offer_id":46798545027151,"sku":"CS2587ILLRGLY10-48","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"96 reactions","offer_id":46798545059919,"sku":"CS2587ILLRGLY10-96","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/sophia-genetics-logo.png?v=1789657266","url":"https:\/\/www.danyel.co.il\/products\/sophia-ddm-community-extended-pharmacogenomics-solution-extpgx-cs2587","provider":"danyel biotech","version":"1.0","type":"link"}