{"product_id":"sic5-6-separase-inhibitor-tbi4075","title":"SIC5-6, Separase inhibitor","description":"\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eProduct Details\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormal Name:\u003c\/strong\u003e 3,3’-(1-((4-Iodophenyl)sulfonyl)piperidine-4,4’diyl)bis(1H-indole)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C\u003csub\u003e27\u003c\/sub\u003eH\u003csub\u003e24\u003c\/sub\u003eIN\u003csub\u003e3\u003c\/sub\u003eO\u003csub\u003e2\u003c\/sub\u003eS\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormula Weight:\u003c\/strong\u003e 581.47\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;97%\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormulation:\u003c\/strong\u003e powder\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in DMSO (up to at least 50 mg\/ml)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStability:\u003c\/strong\u003e ≥ 1 year.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eApplications\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eSeparase inhibitor\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eFunctions\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eInhibitor of separase (a cysteine protease that triggers chromosome segregation during mitosis and is highly overexpressed in many cancers), but not the related protease caspase-1, in vitro. HeLa cells with dysregulated separase activity showed severe chromosome segregation defects on treatment with 30 µM SIC5-6 indicating a potential attractive new chemotherapeutic target.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eApplication Procedures\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eFirst dissolved in DMSO (up to at least 50 mg\/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c!--TBI4075-10MG TBI4075-50MG--\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 13px; font-weight: 700; text-transform: uppercase;\"\u003e\u003cstrong\u003eResearch use only.\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/tribioscience.com\/wp-content\/uploads\/2023\/07\/TBI4075_SIC5-6.pdf\"\u003eDatasheet (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"TriBioScience","offers":[{"title":"10 mg","offer_id":45986575515727,"sku":"TBI4075-10MG","price":409.0,"currency_code":"ILS","in_stock":true},{"title":"50 mg","offer_id":45986575548495,"sku":"TBI4075-50MG","price":1598.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/TBI4075.png?v=1782814767","url":"https:\/\/www.danyel.co.il\/products\/sic5-6-separase-inhibitor-tbi4075","provider":"danyel biotech","version":"1.0","type":"link"}