{"product_id":"seracare-seraseq-inherited-cardiovascular-dna-mix-0740-0132","title":"Seraseq® Inherited Cardiovascular DNA Mix","description":"\u003cp\u003eThe Seraseq® Inherited Cardiovascular DNA Mix is a meticulously designed synthetic DNA reference material, engineered to empower laboratories in the development, validation, and routine monitoring of next-generation sequencing (NGS) and other molecular assays targeting inherited cardiovascular diseases. \u003c\/p\u003e\n\u003cp\u003eThis comprehensive mix encompasses 61 clinically-relevant mutations across 56 genes, representing all major cardiomyopathy types, including hypertrophic, dilated, restrictive, and arrhythmogenic cardiomyopathies, as well as arrhythmias and other related syndromes. \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFEATURES AND BENEFITS\u003c\/strong\u003e \u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eComprehensive Variant Coverage for Inherited Cardiovascular Diseases\u003c\/strong\u003e\u003cstrong\u003e: \u003c\/strong\u003econtains 61 carefully selected mutations in 56 genes, ensuring broad representation of clinically significant variants linked to all major inherited cardiovascular diseases. \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eExpertly Designed:\u003c\/strong\u003e crafted to mimic challenging genomic regions such as microsatellite instability, large deletions in repetitive regions, and large duplications; providing a robust tool for clinical laboratories working on inherited cardiovascular conditions. \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eClinically Relevant Mutations:\u003c\/strong\u003e all 61 variants are classified as pathogenic or likely pathogenic, adhering to ACMG recommendations, the FDA-recognized database, and\/or an expert-reviewed panel. \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSingle-Vial Convenience\u003c\/strong\u003e: Simplify workflows with a highly multiplexed reference material packaged in a single vial, reducing costs and saving time while boosting QC consistency. \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eHigh-Quality Synthetic DNA:\u003c\/strong\u003e manufactured in cGMP compliant and ISO 13485-certified facilities with precision to ensure accurate and reproducible results, providing confidence in your assay performance. Variants quantified using sensitive dPCR assays and blended with the well-characterized GM24385 genomic background. Orthogonally validated by a targeted NGS panel. \u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eSpecifications\u003c\/h2\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eGenes\u003c\/td\u003e\n\u003ctd\u003e56 genes: ABCC9, ACTC1, ACTN2, ALPK3, BAG3, CACNA1C, CALM1, CALM2, CASQ2, CDH2, CTNNA3, CRYAB, DES, DMD, DSC2, DSG2, DSP, EMD, FKTN, FLNC, GAA, GATA6, GLA, HCN4, JPH2, JUP, LAMP2, LDB3, LMNA, MYBPC3, MYH6, MYH7, MYL2, MYL3, MYPN, NEXN, NKX2-5, PKP2, PLN, PPA2, PRDM16, PRKAG2, PTPN11, RAF1, RBM20, RYR2, SCN5A, TMEM43, TNNC1, TNNI3, TNNI3K, TNNT2, TPM1, TTR, TTN, SHOC2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eVariants\u003c\/td\u003e\n\u003ctd\u003e61 mutations (see the Product Sheet (MKT-01147), the Technical Product Report or the Technical Spreadsheet (MKT-01045) available in the Resources tab for exact details.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDisease Coverage\u003c\/td\u003e\n\u003ctd\u003eHypertrophic, dilated, restrictive, and arrhythmogenic cardiomyopathies, arrhythmias, and other related syndromes. See the technical Spreadsheet (MKT-01045) available in the Resources tab for more information.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNominal Concentration\u003c\/td\u003e\n\u003ctd\u003e10 ng\/µL (see the Technical Product Report for the exact concentration)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat\u003c\/td\u003e\n\u003ctd\u003ePurified DNA\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFill Volume\u003c\/td\u003e\n\u003ctd\u003e1 vial x 25 µL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTotal Mass\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;250 ng\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eExpected Variant Allele Frequencies (VAFs)\u003c\/td\u003e\n\u003ctd\u003e~50%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBuffer\u003c\/td\u003e\n\u003ctd\u003e1 mM Tris, 0.1 mM EDTA; pH 8.0 aqueous\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\u003ch2\u003eDocuments\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.seracare.com\/globalassets\/seracare-resources\/ds-0740-0132-seraseq-inherited-cancer-cardiovascular-dna-mix.pdf\" target=\"_blank\" rel=\"noopener\"\u003eData Sheet for Seraseq® Inherited Cardiovascular DNA Mix (Data Sheet)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.seracare.com\/globalassets\/seracare-resources\/pi-0740-0132-seraseq-inherited-cancer-cardiovascular-dna-mix.pdf\" target=\"_blank\" rel=\"noopener\"\u003ePackage Insert for Seraseq® Inherited Cardiovascular DNA Mix (Package Insert)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.seracare.com\/globalassets\/seracare-resources\/ts-0740-0132-seraseq-inherited-cancer-cardiovascular-dna-mix.xlsx\" target=\"_blank\" rel=\"noopener\"\u003eTechnical Spreadsheet for Seraseq® Inherited Cardiovascular DNA Mix (Technical Spreadsheet)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.seracare.com\/globalassets\/seracare-resources\/nrl-seraseq-dna-mix.pdf\" target=\"_blank\" rel=\"noopener\"\u003eSeraseq DNA Mix Non-Requirement Letter (SDS Non-Requirement Letter)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eOrdering Information\u003c\/h2\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eCat. no.\u003c\/th\u003e\n\u003cth\u003eProduct\u003c\/th\u003e\n\u003cth\u003eSize\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\u003ctr\u003e\n\u003ctd\u003e0740-0132\u003c\/td\u003e\n\u003ctd\u003eSeraseq® Inherited Cardiovascular DNA Mix\u003c\/td\u003e\n\u003ctd\u003e1 x 25 µL\u003c\/td\u003e\n\u003c\/tr\u003e\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"SeraCare","offers":[{"title":"Default Title","offer_id":46798516486223,"sku":"0740-0132","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/0740-0132.jpg?v=1789656042","url":"https:\/\/www.danyel.co.il\/products\/seracare-seraseq-inherited-cardiovascular-dna-mix-0740-0132","provider":"danyel biotech","version":"1.0","type":"link"}