{"product_id":"seracare-seraseq-gdna-brca1-2-lgr-somatic-mutation-mix-0730-0567","title":"Seraseq® gDNA BRCA1\/2 LGR Somatic Mutation Mix","description":"\u003cp\u003eGenetic testing of the tumor suppressor genes BRCA1 and BRCA2 allows for the identification of DNA variants which are associated with a significantly elevated lifetime risk of breast, ovarian, pancreatic and prostate cancer. Large genomic rearrangements (LGRs) include deletions, duplications and\/or insertions often involving whole exons. Usually pathogenic, they have been reported to account for up to 27% of the overall BRCA1[1] and 5% of BRCA2 disease-causing mutations [2] with a strong founder effect accounting for about 1\/3rd of all disease diagnosis. Accurate detection of a BRCA1 or BRCA2 pathogenic variant has immense impact on clinical management of disease including patient’s eligibility for new PARP inhibitors.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eLGC Clinical Diagnostics has developed BRCA Reference Materials which include 10 variants in BRCA1 and 10 variants in BRCA2 ranging in size from SNVs to insertions and\/or deletions over 500 bp (11 exon-level large rearrangements), resulting in a variety of phenotypic alterations at the amino acid level, including missense, nonsense, frameshift, stop-gain\/loss, splice-site, and insertion\/deletion of partial or up to two exons (see Product Sheet MKT-00818 for more details).\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eFEATURES AND BENEFITS•Develop, monitor, validate and challenge your hybrid capture-based targeted NGS assays with confidence using a highly multiplexed reference material containing biomarkers important in BRCA-driven cancers.• Single sample with 20 pathogenic BRCA1\/2 variants (11 LGRs, 9 deletions, 5 SNVs, 4 indels, and 2 insertions).• Mutation targets quantitated by highly sensitive dPCR assays, and orthogonally analyzed by NGS.• All mutations are blended against the well-characterized GM24385 human genomic DNA as ‘wildtype’ background material. • Available as full process (FFPE curl) or purified genomic DNA at various allele frequencies suited for either somatic or germline testing.•Manufactured in GMP-compliant and ISO 13485-certified facilities.\u003c\/p\u003e\u003ch2\u003eDocuments\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.seracare.com\/globalassets\/seracare-resources\/ps-0730-0567-seraseq-gdna-brca12-lgr-Somatic-Mutation-Mix.pdf\" target=\"_blank\" rel=\"noopener\"\u003eSeraseq gDNA BRCA12 LGR Somatic Mutation Mix (Product Sheet)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.seracare.com\/globalassets\/seracare-resources\/pi-0730-0567-seraseq-gdna-brca12-lgr-somatic.pdf\" target=\"_blank\" rel=\"noopener\"\u003eSeraseq gDNA BRCA1\/2 LGR Somatic Mutation Mix PI (Package Insert)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.seracare.com\/globalassets\/seracare-resources\/ts-0730-0564.0567.0568-seraseq-brca1-2-lgr-rm.xlsx\" target=\"_blank\" rel=\"noopener\"\u003eTechnical Spreadsheet for Seraseq BRCA 1\/2 LGR Reference Materials (Technical Spreadsheet)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.seracare.com\/globalassets\/seracare-resources\/nrl-0730-0567.0570-seraseq-gdna-brca.pdf\" target=\"_blank\" rel=\"noopener\"\u003eSeraseq gDNA BRCA1 Non-Requirement Letter (SDS Non-Requirement Letter)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eOrdering Information\u003c\/h2\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eCat. no.\u003c\/th\u003e\n\u003cth\u003eProduct\u003c\/th\u003e\n\u003cth\u003eSize\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\u003ctr\u003e\n\u003ctd\u003e0730-0567\u003c\/td\u003e\n\u003ctd\u003eSeraseq® gDNA BRCA1\/2 LGR Somatic Mutation Mix\u003c\/td\u003e\n\u003ctd\u003e1 x 25 µL\u003c\/td\u003e\n\u003c\/tr\u003e\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"SeraCare","offers":[{"title":"Default Title","offer_id":46798515765327,"sku":"0730-0567","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/0730-0567.jpg?v=1789656023","url":"https:\/\/www.danyel.co.il\/products\/seracare-seraseq-gdna-brca1-2-lgr-somatic-mutation-mix-0730-0567","provider":"danyel biotech","version":"1.0","type":"link"}