{"product_id":"seracare-seraseq-ffpe-tumor-fusion-rna-v4-reference-material-0710-0496","title":"Seraseq® FFPE Tumor Fusion RNA v4 Reference Material","description":"\u003cp\u003eAs the diagnostic testing paradigm for chromosomal translocations and other complex structural variants continues to shift from single-site Fluorescent In Situ Hybridization (FISH) and targeted RT-PCR to highly multiplexed next-generation sequencing (NGS) assays, there is increasing need for highly multiplexed reference materials for these difficult mutations.\u003c\/p\u003e\u003cp\u003eThe Seraseq FFPE Tumor Fusion RNA Reference Material v4 contains 18 clinically significant RNA fusions which are prevalent across different types of solid tumors, in an efficient single-sample format. RNA transcripts carrying structural variants are engineered into well-characterized wild-type cells. Cells are formalin-fixed and embedded in paraffin, and the FFPE block is cut into 10-micron sections, each of which typically yields \u0026gt;400 ng of purified total RNA. The transcript level for each fusion is quantified using highly sensitive digital PCR to establish ground-truth (and orthogonally validated with NGS), which helps ensure the material remains constant over time.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e18 clinically relevant fusions evaluate assay sensitivity and specificity for important diagnostic, prognostic, and therapeutic targets\u003c\/li\u003e\n\u003cli\u003eFull-process FFPE format may be treated like a clinical specimen, which can reveal pre-analytic variability\u003c\/li\u003e\n\u003cli\u003e Quantification of transcript levels by dPCR establishes ground-truth and simplifies dilutions for Limit of Detection (LoD) experiments\u003c\/li\u003e\n\u003cli\u003eWell-characterized GM24385 human genomic DNA as background wild-type material\u003c\/li\u003e\n\u003cli\u003e Manufactured in GMP-compliant and ISO 13485-certified facilities\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eFor research use only. Not for use in diagnostic procedures.\u003c\/p\u003e\u003ch2\u003eSpecifications\u003c\/h2\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e# of Fusions\u003c\/td\u003e\n\u003ctd\u003e18\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSize\u003c\/td\u003e\n\u003ctd\u003e10 µm\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat\u003c\/td\u003e\n\u003ctd\u003eFFPE\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRNA Yield\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;400 ng\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\u003ch2\u003eDocuments\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.seracare.com\/globalassets\/seracare-resources\/ps-mkt-00443-02-seracare_seraseq_fusion_rna_ref_mat_.pdf\" target=\"_blank\" rel=\"noopener\"\u003eSeraseq Fusion RNA Reference Materials (Product Sheet)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.seracare.com\/globalassets\/seracare-resources\/pi-0710-0496-seraseq-ffpe-fusion-rna-v4-reference-material.pdf\" target=\"_blank\" rel=\"noopener\"\u003eSeraseq FFPE Fusion RNA v4 Reference Material (Package Insert)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.seracare.com\/globalassets\/seracare-resources\/tss-0710-0496.0497-seraseq-ffpe-tumor-fusion-rna-v4.xlsx\" target=\"_blank\" rel=\"noopener\"\u003eTechnical Spreadsheet for Seraseq Tumor Fusion RNA v4 Reference Materials (Technical Spreadsheet)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.seracare.com\/globalassets\/seracare-resources\/sds-seraseq-ffpe.pdf\" target=\"_blank\" rel=\"noopener\"\u003eSeraseq FFPE Safety Data Sheet (Safety Data Sheet)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eOrdering Information\u003c\/h2\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eCat. no.\u003c\/th\u003e\n\u003cth\u003eProduct\u003c\/th\u003e\n\u003cth\u003eSize\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\u003ctr\u003e\n\u003ctd\u003e0710-0496\u003c\/td\u003e\n\u003ctd\u003eSeraseq® FFPE Tumor Fusion RNA v4 Reference Material\u003c\/td\u003e\n\u003ctd\u003e1 x 10 µm\u003c\/td\u003e\n\u003c\/tr\u003e\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"SeraCare","offers":[{"title":"Default Title","offer_id":46798510096463,"sku":"0710-0496","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/0710-0496.jpg?v=1789655814","url":"https:\/\/www.danyel.co.il\/products\/seracare-seraseq-ffpe-tumor-fusion-rna-v4-reference-material-0710-0496","provider":"danyel biotech","version":"1.0","type":"link"}