{"product_id":"seracare-seraseq-ctdna-mrd-mix-0710-3671","title":"Seraseq® ctDNA MRD Mix","description":"\u003cp\u003eMRD monitoring typically involves measuring signs of a cancer in order to inform decisions about treatment escalation and de-escalation. Typically, this can be facilitated by use of less invasive techniques such as liquid biopsy (ctDNA), to monitor cancer-specific somatic variants. A patient-derived approach to the application of ctDNA-based MRD monitoring starts with a tumor profiling analysis to identify clinically relevant tumor variants that constitute the patient’s genomic profile. Following this, a targeted panel\/assay containing a subset of the gene variants can be designed for disease monitoring by detecting presence or absence of circulating tumor (ct) DNA variants in the patient’s blood sample. These patient-derived MRD analyses represent a paradigm shift in disease monitoring and are rapidly being developed by many assay vendors while best clinical practices are being developed in parallel.\u003c\/p\u003e\n\u003cp\u003eSeraCare has developed a novel ctDNA MRD mutation mix designed to support the development, validation and clinical deployment of a ctDNA-based patient-derived MRD monitoring NGS assays. The new Seraseq ctDNA MRD Mix product is constructed from a combination of a diseased human cell line, its SNP-matched normal cell line, and biosynthetic DNA containing variants commonly targeted by therapeutic drugs. The blended DNA is fragmented, sized to mimic ctDNA fragment sizes, and serially diluted to tumor fraction (TF) of 0.5%.\u003c\/p\u003e\u003ch2\u003eSpecifications\u003c\/h2\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e# of Variants\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;600 exonic variants\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e# of Vials\u003c\/td\u003e\n\u003ctd\u003e1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFill Volume\u003c\/td\u003e\n\u003ctd\u003e20 µL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eConcentration\u003c\/td\u003e\n\u003ctd\u003e10 ng\/µl\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTotal Mass\u003c\/td\u003e\n\u003ctd\u003e200 ng\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat\u003c\/td\u003e\n\u003ctd\u003ePurified DNA in buffer (Tris\/EDTA)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\u003ch2\u003eDocuments\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.seracare.com\/globalassets\/seracare-resources\/ps-0710-2146-mkt-00617-seraseq-ctdna-mrd-panel-mix.pdf\" target=\"_blank\" rel=\"noopener\"\u003eSeraseq® ctDNA MRD Mix (Product Sheet)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.seracare.com\/globalassets\/seracare-resources\/pi-0710-2146-seraseq-ctdna-mrd-panel-mix.pdf\" target=\"_blank\" rel=\"noopener\"\u003eSeraseq ctDNA MRD Mix - Package Insert (Package Insert)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.seracare.com\/globalassets\/seracare-resources\/nrl-seraseq-ctdna-mrd-tumor.pdf\" target=\"_blank\" rel=\"noopener\"\u003eSeraseq ctDNA MRD Tumor Non-Requirement Letter (SDS Non-Requirement Letter)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eOrdering Information\u003c\/h2\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eCat. no.\u003c\/th\u003e\n\u003cth\u003eProduct\u003c\/th\u003e\n\u003cth\u003eSize\u003c\/th\u003e\n\u003cth\u003eTumor Level\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e0710-3671\u003c\/td\u003e\n\u003ctd\u003eSeraseq® ctDNA MRD 0.5% Tumor\u003c\/td\u003e\n\u003ctd\u003e1 x 20 µL\u003c\/td\u003e\n\u003ctd\u003e0.5%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e0710-3672\u003c\/td\u003e\n\u003ctd\u003eSeraseq® ctDNA MRD 0.05% Tumor\u003c\/td\u003e\n\u003ctd\u003e1 x 20 µL\u003c\/td\u003e\n\u003ctd\u003e0.05%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e0710-3673\u003c\/td\u003e\n\u003ctd\u003eSeraseq® ctDNA MRD 0.005% Tumor\u003c\/td\u003e\n\u003ctd\u003e1 x 20 µL\u003c\/td\u003e\n\u003ctd\u003e0.005%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e0710-3670\u003c\/td\u003e\n\u003ctd\u003eSeraseq® ctDNA MRD 0% Tumor\u003c\/td\u003e\n\u003ctd\u003e1 x 20 µL\u003c\/td\u003e\n\u003ctd\u003e0%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"SeraCare","offers":[{"title":"0.5% Tumor","offer_id":46798513766479,"sku":"0710-3671","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"0.05% Tumor","offer_id":46798513799247,"sku":"0710-3672","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"0.005% Tumor","offer_id":46798513832015,"sku":"0710-3673","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"0% Tumor","offer_id":46798513864783,"sku":"0710-3670","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/0710-3671.jpg?v=1789655939","url":"https:\/\/www.danyel.co.il\/products\/seracare-seraseq-ctdna-mrd-mix-0710-3671","provider":"danyel biotech","version":"1.0","type":"link"}