{"product_id":"recombinant-human-cd38-protein-his-tag-enzymatic-activity-tbp0004","title":"Recombinant Human CD38 Protein (His Tag), Enzymatic Activity","description":"\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eProduct Description\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eCluster of differentiation 38 (CD38), also known as ADP-ribosyl cyclase, is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B and natural killer cells. It shares several characteristics with ADP-ribosyl cyclase 2 CD157. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. It also functions in cell adhesion, signal transduction and calcium signaling. CD38 has been used as a prognostic marker in leukemia. It can also be used to identify plasma cells. This enzyme is validated for CD38 Enzymatic activity application.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eProduct Details\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cu\u003eSource:\u003c\/u\u003e Human\u003c\/p\u003e\n\u003cp\u003e\u003cu\u003eExpression system:\u003c\/u\u003e HEK293 Cells.\u003c\/p\u003e\n\u003cp\u003e\u003cu\u003eProtein Construction:\u003c\/u\u003e Val43 ~ Ile300 with a C terminal 6 His tag.\u003c\/p\u003e\n\u003cp\u003e\u003cu\u003eUniProt No:\u003c\/u\u003e P28907\u003c\/p\u003e\n\u003cp\u003e\u003cu\u003eAlternative Names:\u003c\/u\u003e ADP-ribosyl cyclase\/cyclic ADP-ribose hydrolase 1, CD38, ADPRC 1, ADPRC1.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eProduct Specification\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cu\u003eN Terminal Sequence Analysis:\u003c\/u\u003e Val43.\u003c\/p\u003e\n\u003cp\u003e\u003cu\u003ePredicted Molecular Weight:\u003c\/u\u003e 31.2 kDa (269aa)\u003c\/p\u003e\n\u003cp\u003eSDSPAGE: 43-45 kDa in SDS-PAGE under reducing conditions.\u003c\/p\u003e\n\u003cp\u003e\u003cu\u003eConcentration:\u003c\/u\u003e 1mg\/ml (determined by Bradford assay).\u003c\/p\u003e\n\u003cp\u003e\u003cu\u003eFormulation:\u003c\/u\u003e Liquid in 50mM MES buffer (pH 6.5) containing 100mM NaCl, 10% glycerol.\u003c\/p\u003e\n\u003cp\u003e\u003cu\u003eConcentration:\u003c\/u\u003e 1mg\/mL.\u003c\/p\u003e\n\u003cp\u003e\u003cu\u003ePurity:\u003c\/u\u003e \u0026gt; 95% by SDS-PAGE.\u003c\/p\u003e\n\u003cp\u003e\u003cu\u003eTag:\u003c\/u\u003e His-Tag.\u003c\/p\u003e\n\u003cp\u003e\u003cu\u003eBiological Activity:\u003c\/u\u003e Measured by its ability to convert the substrate nicotinamide guanine dinucleotide (NGD+) to cyclic GDP ribose. The specific activity is \u0026gt; 2,500 pmoles\/min\/μg.\u003c\/p\u003e\n\u003cp\u003e\u003cu\u003eStorage Condition:\u003c\/u\u003e Store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.\u003c\/p\u003e\n\u003cp\u003e\u003cu\u003eEndotoxin:\u003c\/u\u003e \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\u003cp\u003e\u003cu\u003eProtein Sequence:\u003c\/u\u003e Val43 ~ Ile300.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eApplications\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eEnzymatic Activity, and protein assay by SDS-PAGE\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003c!--TBP0004-50UG TBP0004-500UG--\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 13px; font-weight: 700; text-transform: uppercase;\"\u003e\u003cstrong\u003eResearch use only.\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/tribioscience.com\/wp-content\/uploads\/2024\/02\/TBP0004-rhCD38-Enzyme_data-sheet_V01_2024.pdf\"\u003eDatasheet (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/tribioscience.com\/wp-content\/uploads\/2024\/02\/TBP0004_Recombinant-Human-CD38-Protein-Safety-Data-Sheet.pdf\"\u003eMSDS (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"TriBioScience","offers":[{"title":"50 ug","offer_id":45986492383311,"sku":"TBP0004-50UG","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"500 ug","offer_id":45986492416079,"sku":"TBP0004-500UG","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/TBP0002.png?v=1782812509","url":"https:\/\/www.danyel.co.il\/products\/recombinant-human-cd38-protein-his-tag-enzymatic-activity-tbp0004","provider":"danyel biotech","version":"1.0","type":"link"}