{"product_id":"phenylhexyl-isothiocyanate-chemopreventive-hdac-inhibitor-p53-reactivator-tbi5258","title":"Phenylhexyl isothiocyanate, Chemopreventive; HDAC inhibitor; p53 reactivator","description":"\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eProduct Details\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormal Name:\u003c\/strong\u003e 6-isothiocyanatohexylbenzene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAlternate Names:\u003c\/strong\u003e PHITC; PHI\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C\u003csub\u003e13\u003c\/sub\u003eH\u003csub\u003e17\u003c\/sub\u003eNS\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormula Weight:\u003c\/strong\u003e 219.40\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 133920-06-6\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;98%\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormulation:\u003c\/strong\u003e Liquid\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in DMSO (25 mg\/ml)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStability:\u003c\/strong\u003e ≥ 2 years.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eApplications\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eChemopreventive; HDAC inhibitor; p53 reactivator\u003c\/p\u003e\n\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eFunctions\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eIsothiocyanate constituents of cruciferous vegetables are potent chemopreventive agents for carcinogen-induced cancers in rodents. PHITC was the most potent in a series of synthetic arylalkyl isothiocyantates at inhibition of tumorigenicity by NNK, a tobacco-derived nitrosamine, in a mouse model. It was also found to induce apoptosis and inhibit leukemia cell growth in vivo and was shown to have dual function as a histone deacetylase inhibitor and hypomethylating agent. PHITC was also shown to restore the activity of mutant p53 and reactivate the p53 pathway in human myeloid leukemia M2 cells.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eApplication Procedures\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eFirst dissolved in DMSO (25 mg\/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.\u003c\/p\u003e\n\u003cp\u003e\u003c!--TBI5258-5MG TBI5258-25MG--\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 13px; font-weight: 700; text-transform: uppercase;\"\u003e\u003cstrong\u003eResearch use only.\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/tribioscience.com\/wp-content\/uploads\/2023\/08\/TBI5258_Data_Sheet.pdf\"\u003eDatasheet (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"TriBioScience","offers":[{"title":"5 mg","offer_id":45986652749903,"sku":"TBI5258-5MG","price":409.0,"currency_code":"ILS","in_stock":true},{"title":"25 mg","offer_id":45986652782671,"sku":"TBI5258-25MG","price":821.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/TBI5258.png?v=1782816179","url":"https:\/\/www.danyel.co.il\/products\/phenylhexyl-isothiocyanate-chemopreventive-hdac-inhibitor-p53-reactivator-tbi5258","provider":"danyel biotech","version":"1.0","type":"link"}