{"product_id":"nanoassemblr-blaze-cartridges-and-tubing-kits-1000459","title":"NanoAssemblr™ Blaze cartridges and tubing kits","description":"\u003cp\u003eNanoAssemblr™ Blaze cartridges and tubing kits are validated for single-use, reducing the risk of cross-contamination during process development of LNP formulations. Starting June 2025, customers can purchase the new NxGen™ Blaze cartridges for the NanoAssemblr™ Blaze nanoparticle formulation system and will have the option to reuse them.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAutomate In-line dilution: Cartridges are available with in-line dilution, simplifying LNP workflows and saving time while ensuring particle stability.\u003c\/li\u003e\n\u003cli\u003eReproducible scale-up:  NxGen™ technology ensures efficient transfer of critical process parameters (CPP) during scale-up from preclinical development to clinical and commercial production.\u003c\/li\u003e\n\u003cli\u003eFlexible flow rate options:  NxGen™ 400 and NxGen™ 500 cartridges support flow rates from 4 – 115 mL\/min using the same NxGen™ mixing architecture but in different dimensions, enabling flexibility for formulation-specific process parameters.\u003c\/li\u003e\n\u003cli\u003eClosed-system environment The single-use tubing kit enables connection to external vessels and supports a closed-system environment on the NanoAssemblr™ Blaze+ system, allowing optimization of manufacturing processes used during clinical development and minimizing risk.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cimg class=\"img-responsive center-block\" src=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/uPruUag4TOeATPUuvRs8hQ-original\" style=\"width:1000px;\"\u003e\u003c\/p\u003e\n\n\u003cp\u003esaRNA-LNPs are biologically potent \u003cem\u003ein vitro \u003c\/em\u003eand \u003cem\u003ein vivo\u003c\/em\u003e, inducing expression of SARS-CoV-2 antigen and robust immune responses. \u003cstrong\u003eA)\u003c\/strong\u003e BHK 570 cells were transfected with decreasing amounts of saRNA-LNPs and\u003cstrong\u003e B)\u003c\/strong\u003e the percentage of cells expressing SARS-CoV-2 spike protein was measured using an anti-spike conjugated AlexaFluor488 antibody with 95% confidence intervals in shaded areas. \u003cstrong\u003eC)\u003c\/strong\u003e EC50 values were similar across systems. Error bars represent 95% confidence intervals.\u003cstrong\u003e D)\u003c\/strong\u003e BALB\/c mice were used for a 42-day prime and boost dose study. \u003cstrong\u003eE)\u003c\/strong\u003e Robust SARS-CoV-2-specific IgG responses in serum were observed at day 21 and 42 post-injection for each condition. Error bars are 1 standard deviation. 1x PBS vs instrument comparison p-value for a given time point using post-hoc Tukey test after one-way ANOVA (p≤.05: *, p≤.01: **, p≤.001: ***, p≤.0001: ****). \u003c\/p\u003e","brand":"Cytiva","offers":[{"title":"In-line \/ Cartridge (1000459)","offer_id":45982117331023,"sku":"1000459","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"In-line \/ Cartridge (1000461)","offer_id":45982117363791,"sku":"1000461","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"N\/A \/ Tubing","offer_id":45982117396559,"sku":"1000535","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"None \/ Cartridge (1000460)","offer_id":45982117429327,"sku":"1000460","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"None \/ Cartridge (1000458)","offer_id":45982117462095,"sku":"1000458","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/vjjzvF1QRQauhav0aeV3AA-original-png_179837ef-d41c-4b76-9fae-74d3a552e9de.png?v=1785958509","url":"https:\/\/www.danyel.co.il\/products\/nanoassemblr-blaze-cartridges-and-tubing-kits-1000459","provider":"danyel biotech","version":"1.0","type":"link"}