{"product_id":"msk-impact-flex-powered-with-sophia-ddm-bs0132","title":"MSK-IMPACT® Flex powered with SOPHiA DDM™","description":"\u003cp\u003eOptimize lab efficiency with a modular solution built on the expertly curated MSK-IMPACT® content, covering 533 DNA genes and 140 RNA genes, with the option to add RNA and HRD analysis at a sample level. Learn More \u0026gt;\u003c\/p\u003e\u003cp\u003eSample-to-report bundle: capture-based target enrichment and library preparation kit combined with the analytical capabilities of the SOPHiA DDM™ Platform.\u003c\/p\u003e\u003ch2\u003eSpecifications\u003c\/h2\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eGene content\u003c\/th\u003e\n\u003ctd\u003e533 DNA (incl. 505 genes from MSK-IMPACT®)\u003cbr\u003e140 RNA\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eDiseases covered\u003c\/th\u003e\n\u003ctd\u003eMulti-cancer (any solid tumor)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eDetected variants\u003c\/th\u003e\n\u003ctd\u003eFrom DNA:\u003cbr\u003eSNVs\/Indels in 533 genes\u003cbr\u003eWhole gene amplifications and deletions in 520 genes\u003cbr\u003eGene-level and exon-level CNVs in 49 genes\u003cbr\u003eTERT promoter\u003cbr\u003eTMB\u003cbr\u003eMSI\u003cbr\u003eHRD (optional)\u003cbr\u003eFrom RNA:\u003cbr\u003ePartner-agnostic fusions in 135 genes\u003cbr\u003eExon skipping events in 9 genes\u003cbr\u003eGene expression in 56 genes\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSample type\u003c\/th\u003e\n\u003ctd\u003eFFPE, fresh-frozen\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStarting material\u003c\/th\u003e\n\u003ctd\u003e50 ng DNA (min. 10 ng), 50 ng RNA (min. 10 ng)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSequencer compatibility\u003c\/th\u003e\n\u003ctd\u003eIllumina® NextSeq® 550\/1000\/2000\u003cbr\u003eIllumina® NovaSeq™ 6000, X\u003cbr\u003eCompatible with MGI and Element sequencers\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eLibrary preparation time\u003c\/th\u003e\n\u003ctd\u003e1.5 days (DNA only)\u003cbr\u003e2 days (DNA+RNA)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eAnalysis time from FASTQ\u003c\/th\u003e\n\u003ctd\u003eDNA only – \u0026lt;10 hours\u003cbr\u003eDNA + RNA – \u0026lt;15 hours\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eRegulatory status\u003c\/th\u003e\n\u003ctd\u003eResearch Use Only (RUO)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eApplication Type\u003c\/th\u003e\n\u003ctd\u003eBundle (sample-to-report)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eLimit of detection at 95% (LOD95)\u003c\/th\u003e\n\u003ctd\u003e5%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eRecommended paired-end reads\u003c\/th\u003e\n\u003ctd\u003eDNA capture – 51 million\u003cbr\u003eRNA capture – 11 million\u003cbr\u003eDNA whole genome sequencing (at ~1x coverage) – 20 million\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\u003ch2\u003eFlexible CGP analysis without compromise\u003c\/h2\u003e\u003cp\u003eAchieve scalable analysis of solid tumors with an agile and modular approach to comprehensive genomic profiling (CGP), eliminating the need for multiple tests.\u003c\/p\u003e\u003cp\u003eBuilt on the expert-designed content of MSK-IMPACT® and combined with the adaptive analytics of the SOPHiA DDM™ Platform, MSK-IMPACT® Flex powered with SOPHiA DDM™ delivers high-resolution profiling of complex biomarkers from DNA and RNA in a single, end-to-end workflow.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eExpert content design\u003c\/strong\u003e – Built on the backbone of MSK-IMPACT®, curated by Memorial Sloan Kettering Cancer Center (MSK) experts and verified in over 1,000 MSK publications.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eIn-depth CNV detection\u003c\/strong\u003e – Gain high-resolution profiling of gene and exon-level CNVs, with genome-wide copy number context.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eComprehensive profiling\u003c\/strong\u003e – Detect all major variant classes (SNVs\/Indels, CNVs, partner-agnostic fusions, exon-skipping events, gene expression) and complex signatures (TMB, MSI, HRD).\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eMaximized lab efficiency\u003c\/strong\u003e – Reduce turnaround time by eliminating send-outs and covering DNA and RNA analysis in a single, automated workflow.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eModular analysis\u003c\/strong\u003e – Add RNA and HRD analysis at the sample level to tailor biomarker coverage, reducing unecessary testing.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eEnhanced interpretation\u003c\/strong\u003e – Navigate variant interpretation at every level, from individual alterations to broader clinical context, with OncoPortal™ Knowledge Base.\u003c\/p\u003e\u003ch2\u003eStreamline your workflow\u003c\/h2\u003e\u003cp\u003eBoost lab efficiency with a single, streamlined, end-to-end NGS workflow that allows you to analyze multiple data modalities in one sequencing run. All variant detection and interpretation steps are powered by the SOPHiA DDM™ Platform, giving you full control over your data and samples.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAdvancing precision oncology – your way\u003c\/strong\u003e – The modular architecture of the SOPHiA DDM™ Platform enables a truly flexible approach to CGP. You can easily integrate analytical modules – DNA capture, RNA capture and\/or low-pass whole-genome sequencing analysis – at the sample level. This approach allows you to tailor workflows to your institution’s specific needs and deliver the most relevant insights for every case.\u003c\/p\u003e\u003cp\u003eTake your research further by complementing your tissue analysis with SOPHiA DDM™ for Liquid Biopsy, enabling advanced monitoring of resistance and a comprehensive view of the tumor landscape.\u003c\/p\u003e\u003ch2\u003eDocuments\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3e30vlyff459p.cloudfront.net\/2b75c131-2c1d-4268-be32-67d15945dcb8\/2bf4a2ec-6501-4bc1-8d0e-df5357434a59\/2bf4a2ec-6501-4bc1-8d0e-df5357434a59_source__v.pdf\" target=\"_blank\" rel=\"noopener\"\u003eFact Sheet: MSK-IMPACT® Flex powered with SOPHiA DDM™\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3e30vlyff459p.cloudfront.net\/2b75c131-2c1d-4268-be32-67d15945dcb8\/f786fd6b-b532-46b5-90ef-d9aa164968e5\/f786fd6b-b532-46b5-90ef-d9aa164968e5_source__v.pdf\" target=\"_blank\" rel=\"noopener\"\u003eFlyer: MSK-IMPACT® Flex powered with SOPHiA DDM™\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3e30vlyff459p.cloudfront.net\/2b75c131-2c1d-4268-be32-67d15945dcb8\/a1dcde56-e7ef-470c-bf47-b63f7d85f0c4\/a1dcde56-e7ef-470c-bf47-b63f7d85f0c4_source__v.pdf\" target=\"_blank\" rel=\"noopener\"\u003ePoster: MSK-IMPACT® Flex powered with SOPHiA DDM™\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eOrdering Information\u003c\/h2\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eProduct code\u003c\/th\u003e\n\u003cth\u003eSequencer\u003c\/th\u003e\n\u003cth\u003eReactions\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eBS0132ILLRSMY13-16\u003c\/td\u003e\n\u003ctd\u003eIllumina\u003c\/td\u003e\n\u003ctd\u003e16\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBS0132ILLRSMY13-32\u003c\/td\u003e\n\u003ctd\u003eIllumina\u003c\/td\u003e\n\u003ctd\u003e32\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBS0132ILLRSMY13-48\u003c\/td\u003e\n\u003ctd\u003eIllumina\u003c\/td\u003e\n\u003ctd\u003e48\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBS0132ILLRSMY13-96\u003c\/td\u003e\n\u003ctd\u003eIllumina\u003c\/td\u003e\n\u003ctd\u003e96\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBS0132MGIRSMY13-16\u003c\/td\u003e\n\u003ctd\u003eMGI\u003c\/td\u003e\n\u003ctd\u003e16\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBS0132MGIRSMY13-32\u003c\/td\u003e\n\u003ctd\u003eMGI\u003c\/td\u003e\n\u003ctd\u003e32\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBS0132MGIRSMY13-48\u003c\/td\u003e\n\u003ctd\u003eMGI\u003c\/td\u003e\n\u003ctd\u003e48\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBS0132MGIRSMY13-96\u003c\/td\u003e\n\u003ctd\u003eMGI\u003c\/td\u003e\n\u003ctd\u003e96\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003e\u003cem\u003eFor Research Use Only. Not for use in diagnostic procedures.\u003c\/em\u003e\u003c\/p\u003e","brand":"SOPHiA GENETICS","offers":[{"title":"Illumina \/ 16 reactions","offer_id":46798539489359,"sku":"BS0132ILLRSMY13-16","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Illumina \/ 32 reactions","offer_id":46798539522127,"sku":"BS0132ILLRSMY13-32","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Illumina \/ 48 reactions","offer_id":46798539554895,"sku":"BS0132ILLRSMY13-48","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Illumina \/ 96 reactions","offer_id":46798539587663,"sku":"BS0132ILLRSMY13-96","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"MGI \/ 16 reactions","offer_id":46798539620431,"sku":"BS0132MGIRSMY13-16","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"MGI \/ 32 reactions","offer_id":46798539653199,"sku":"BS0132MGIRSMY13-32","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"MGI \/ 48 reactions","offer_id":46798539685967,"sku":"BS0132MGIRSMY13-48","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"MGI \/ 96 reactions","offer_id":46798539718735,"sku":"BS0132MGIRSMY13-96","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/sophia-genetics-logo.png?v=1789657266","url":"https:\/\/www.danyel.co.il\/products\/msk-impact-flex-powered-with-sophia-ddm-bs0132","provider":"danyel biotech","version":"1.0","type":"link"}