{"product_id":"montelukast-leukotriene-cyslt1-antagonist-gpr17-antagonist-tbi2597","title":"Montelukast, Leukotriene CysLT1 antagonist; GPR17 antagonist","description":"\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eProduct Details\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormal Name:\u003c\/strong\u003e 2-[1-[[(1R)-1-[3-[(E)-2-(7-Chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetate, sodium salt\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAlternate Names:\u003c\/strong\u003e MK-0476\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C\u003csub\u003e35\u003c\/sub\u003eH\u003csub\u003e35\u003c\/sub\u003eClNO\u003csub\u003e3\u003c\/sub\u003eS Na\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormula Weight:\u003c\/strong\u003e 608.17\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 151767-02-1\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;98%\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormulation:\u003c\/strong\u003e powder\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in DMSO (up to 60 mg\/ml), in Water (up to 30 mg\/ml) or in Ethanol (up to 60 mg\/ml)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStability:\u003c\/strong\u003e ≥ 1 year.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eApplications\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eLeukotriene  CysLT1 antagonist; GPR17 antagonist\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eFunctions\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003ePotent, selective CysLT1 receptor (leukotriene D4) antagonist (Ki = 0.18 nM). Displays anti-inflammatory and anti-asthmatic effects. Clinically useful agent for treatment of chronic asthma. Attenuates chronic brain injury after focal cerebral ischemia in rodent models. Decreases blood brain barrier dysfunction in mouse models. Blockade of GPR17 by montelukast elevates neural stem and progenitor proliferation.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eApplication Procedures\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eFirst dissolved in DMSO (up to 60 mg\/ml), in Water (up to 30 mg\/ml) or in Ethanol (up to 60 mg\/ml), then diluted to aqueous buffer. Solutions in DMSO, distilled water, or ethanol may be stored at -20°C for up to 1 month.\u003c\/p\u003e\n\u003cp\u003e\u003c!--TBI2597-50MG TBI2597-250MG--\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 13px; font-weight: 700; text-transform: uppercase;\"\u003e\u003cstrong\u003eResearch use only.\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/tribioscience.com\/wp-content\/uploads\/2023\/10\/TBI2597_Montelukast.pdf\"\u003eDatasheet (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/tribioscience.com\/wp-content\/uploads\/2023\/10\/TBI2597_Montelukast_MSDS_2024.pdf\"\u003eMSDS (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"TriBioScience","offers":[{"title":"50 mg","offer_id":45986943336527,"sku":"TBI2597-50MG","price":492.0,"currency_code":"ILS","in_stock":true},{"title":"250 mg","offer_id":45986943369295,"sku":"TBI2597-250MG","price":1970.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/TBI2597.png?v=1782818653","url":"https:\/\/www.danyel.co.il\/products\/montelukast-leukotriene-cyslt1-antagonist-gpr17-antagonist-tbi2597","provider":"danyel biotech","version":"1.0","type":"link"}