{"product_id":"mg-132-proteasome-inhibitor-tbi1309","title":"MG-132, Proteasome inhibitor","description":"\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eProduct Details\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormal Name:\u003c\/strong\u003e N-(Benzyloxycarbonyl)leucinylleucinylleucinal\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAlternate Names:\u003c\/strong\u003e Z-Leu-Leu-Leu-CHO\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C\u003csub\u003e26\u003c\/sub\u003eH\u003csub\u003e41\u003c\/sub\u003eN\u003csub\u003e3\u003c\/sub\u003eO\u003csub\u003e5\u003c\/sub\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormula Weight:\u003c\/strong\u003e 475.63\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 133407-82-6\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;98%\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormulation:\u003c\/strong\u003e powder\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in DMSO (up to 45 mg\/ml), in DMF (up to 45 mg\/ml), or in Ethanol (up to 45 mg\/ml).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStability:\u003c\/strong\u003e ≥ 2 years.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eApplications\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eProteasome inhibitor\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eFunctions\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eSpecific inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50=100 nM with Z-LLL-AMC as substrate). Also inhibits calpain (IC50=1.25 μM) Suppresses gastric cancer cell proliferation and induces macro-autophagy. Activates stress kinases and induces Hsp72. Induces neurite outgrowth. Blocks NFκB activation by blocking IκB proteolysis (IC50=3 μM). Cell permeable.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eApplication Procedures\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eFirst dissolved in DMSO (up to 45 mg\/ml), in DMF (up to 45 mg\/ml), or in Ethanol (up to 45 mg\/ml), then diluted to aqueous buffer. Solutions in DMSO, DMF or ethanol may be stored at -20° for up to 1 week.\u003c\/p\u003e\n\u003cp\u003e\u003c!--TBI1309-5MG TBI1309-25MG--\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 13px; font-weight: 700; text-transform: uppercase;\"\u003e\u003cstrong\u003eResearch use only.\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/tribioscience.com\/wp-content\/uploads\/2023\/06\/TBI1309_MG-132.pdf\"\u003eDatasheet (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"TriBioScience","offers":[{"title":"5 mg","offer_id":45986615001167,"sku":"TBI1309-5MG","price":409.0,"currency_code":"ILS","in_stock":true},{"title":"25 mg","offer_id":45986615033935,"sku":"TBI1309-25MG","price":1642.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/TBI1309.png?v=1782815927","url":"https:\/\/www.danyel.co.il\/products\/mg-132-proteasome-inhibitor-tbi1309","provider":"danyel biotech","version":"1.0","type":"link"}