{"product_id":"mabselect-vl-protein-l-resin-17542001","title":"MabSelect™ VL protein L resin","description":"\u003cp\u003eMabSelect™ VL resin with a redesigned protein L ligand for high binding capacity and improved alkaline stability. For affinity capture of antibody Fabs, bispecifics, and other variants containing a kappa light chain.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHigh dynamic binding capacity protein L resin for efficient capture of antibody Fabs, bispecifics, and variants containing a kappa light chain.\u003c\/li\u003e\n\u003cli\u003eStable when cleaned with 0.1 M NaOH, reducing risk for bioburden incidents.\u003c\/li\u003e\n\u003cli\u003eProvides good resolution for product-related impurities in the capture of bispecific antibodies.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBuilt for a diversifying pipeline\u003c\/p\u003e\n\n\u003cp\u003eAs the diversity of antibody variants increases, so does the need for \u003ca href=\"\/solutions\/bioprocessing\/products-and-solutions\/downstream-bioprocessing\/protein-a-chromatography-solutions\" target=\"_self\"\u003echromatography resins\u003c\/a\u003e that can capture and purify these variants. As an alternative to protein A, protein L resin can be used to capture antibody Fabs, bispecific antibodies, and other molecules containing kappa variants of the variable light (VL) chain. Protein L binds human kappa light chain subtypes 1, 3, and 4 and mouse kappa light chain subtype 1.\u003c\/p\u003e\n\n\u003cp\u003eRedesigned protein L ligand\u003c\/p\u003e\n\n\u003cp\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/78R6xTZSIUGB4Q5N-TlxQA-pdf\" target=\"_self\"\u003eMabSelect™ VL resin\u003c\/a\u003e showed a two-fold increase in binding capacity compared to our \u003ca href=\"\/shop\/chromatography\/resins\/affinity-antibody\/capto-l-antibody-fragment-purification-resin-p-00629\" target=\"_self\"\u003eCapto™ L chromatography resin\u003c\/a\u003e. This higher capacity provides productivity advantages in research and biomanufacturing.\u003c\/p\u003e\n\n\u003cp\u003eMabSelect™ VL resin can withstand cleaning with 0.1 M NaOH, thanks to multimerization and modification of one of the domains of the native protein L ligand.\u003c\/p\u003e\n\n\u003cp\u003eMabSelect™ VL protein L resin is also available in \u003ca href=\"\/shop\/chromatography\/prepacked-columns\/affinity-antibody\/hitrap-mabselect-vl-protein-l-column-p-29317\"\u003e1 mL and 5 mL HiTrap™ prepacked columns for use in research applications\u003c\/a\u003e,  \u003ca href=\"\/shop\/chromatography\/prepacked-columns\/affinity-antibody\/predictor-robocolumn-mabselect-vl-protein-l-minicolumns-p-31816\" target=\"_self\"\u003ePreDictor™ RoboColumn® minicolumns\u003c\/a\u003e for convenient method optimization and parameter screening in process development, and as prepacked \u003ca href=\"\/shop\/chromatography\/prepacked-columns\/affinity-antibody\/mabselect-vl-resin-in-readytoprocess-columns-p-32117\" target=\"_self\"\u003eReadyToProcess™ columns\u003c\/a\u003e. \u003ca href=\"https:\/\/info.cytivalifesciences.com\/mabselectVL-launch.html\"\u003eContact your Cytiva sales representative\u003c\/a\u003e for more information.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/78R6xTZSIUGB4Q5N-TlxQA-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/29704862.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"25 mL","offer_id":45982435934287,"sku":"17542001","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"200 mL","offer_id":45982435967055,"sku":"17542002","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-51569-original-png_73b62389-8cf1-4d57-8b3e-e64056852e80.png?v=1785961086","url":"https:\/\/www.danyel.co.il\/products\/mabselect-vl-protein-l-resin-17542001","provider":"danyel biotech","version":"1.0","type":"link"}