{"product_id":"mabselect-sure-lx-protein-a-resin-17547401","title":"MabSelect SuRe™ LX protein A resin","description":"\u003cp\u003eMabSelect SuRe™ LX is a protein A affinity resin with very high dynamic binding capacity at extended residence times. The chromatography resin is developed for processing of monoclonal antibodies at high titers.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eNovel, alkali-tolerant rProtein A ligand withstands rigorous clean-in-place and sanitization procedures with 0.1 to 0.5 M NaOH.\u003c\/li\u003e\n\u003cli\u003eHigh dynamic binding capacity (DBC) for high titer cultures reduces process time and amount of resin used.\u003c\/li\u003e\n\u003cli\u003eFulfills industrial demands for security of supply, robust performance, and regulatory support.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eExcellent for antibody purification in bioprocess applications\u003c\/p\u003e \u003cp\u003eAlkali tolerance, high capacity and low ligand leakage in combination with the rigid base matrix makes MabSelect SuRe LX an excellent choice for purification of monoclonal antibodies for clinical applications.\u003c\/p\u003e \u003cp\u003ePart of the MabSelect protein A resin family\u003c\/p\u003e \u003cp\u003eMabSelect SuRe LX is a member of the MabSelect family of protein A resins for the capture of monoclonal antibodies at process scale. MabSelect SuRe LX shares features and benefits of MabSelect and MabSelect SuRe such as a rigid, high-flow agarose matrix that ensures excellent pressure\/flow properties, low non-specific binding that leads to low impurity levels in the eluate pool, and an oriented ligand coupling for excellent binding capacity. It also features the same alkali-tolerant rProtein A ligand as MabSelect SuRe. This protein ligand provides greater stability than conventional protein A-based resins in the alkaline conditions used in cleaning-in-place (CIP) and sanitization protocols.\u003c\/p\u003e \u003cp\u003eEnhanced stability of the protein ligand\u003c\/p\u003e \u003cp\u003eThe enhanced alkali stability of MabSelect SuRe LX improves process economy and product quality; cleaning can be performed with cost-effective reagents such as sodium hydroxide, eliminating the need for expensive and hazardous cleaning agents such as Gua-HCl. Process economy is also improved by the increased dynamic binding capacity of MabSelect SuRe LX.\u003c\/p\u003e \u003cp\u003eJust as for MabSelect SuRe, the novel ligand construct of MabSelect SuRe LX has been proven to have an increased stability towards proteases. Therefore, the level of leakage of the MabSelect SuRe LX ligand during elution is low.\u003c\/p\u003e \u003cp\u003ePurification platform design advantage\u003c\/p\u003e \u003cp\u003eMabSelect SuRe has been demonstrated to give generic elution conditions for different monoclonal antibodies, which can be applied also to MabSelect SuRe LX as it utilizes the same ligand. This is an advantage when designing generic purification platform processes. The feature is also correlated to the construction of the MabSelect SuRe protein ligand.\u003c\/p\u003e \u003cp\u003ePrepacked columns and predictor filter plates.\u003c\/p\u003e \u003cp\u003eMabSelect SuRe LX is available in the following formats:\u003c\/p\u003e \u003cp\u003eProcess development scale – prepacked columns and plates\u003c\/p\u003e \u003cul\u003e     \u003cli\u003ePreDictor MabSelect SuRe LX – 96-well plates for high-throughput screening or process development.\u003c\/li\u003e     \u003cli\u003ePreDictor RoboColumn MabSelect Sure LX – miniaturized column format for high-throughput process development.\u003c\/li\u003e     \u003cli\u003eHiScreen MabSelect SuRe LX columns – optimized for method and process development.\u003c\/li\u003e \u003c\/ul\u003e  \u003cp\u003eLab\/research scale – prepacked columns for manual protein purification\u003c\/p\u003e \u003cp\u003eHiTrap MabSelect SuRe LX chromatography columns – for easy use with a syringe, peristaltic pump, or chromatography system.\u003c\/p\u003e \u003cp\u003eLab\/research scale – prepacked columns for automated protein purification and analysis\u003c\/p\u003e \u003cp\u003eHiTrap MabSelect SuRe LX chromatography columns – for easy use with a syringe, peristaltic pump, or chromatography system.\u003c\/p\u003e \u003cp\u003eProcess scale protein purification – prepacked columns\u003c\/p\u003e \u003cp\u003eReadyToProcess MabSelect SuRe LX columns – 1 L and larger chromatography columns for clinical manufacturing that avoid the need for cleaning and cleaning validation.\u003c\/p\u003e \u003cp\u003eFor samples, contact your local sales representative or \u003ca href=\"\/support\/contact-us\"\u003ecustomer support\u003c\/a\u003e.\u003c\/p\u003e  \u003cp\u003eMabSelect SuRe LX protein A resin builds on the proven track record of MabSelect and MabSelect SuRe resins in downstream processing of monoclonal antibodies.\u003c\/p\u003e  \u003cp\u003eLearn about prepacked \u003ca href=\"\/shop\/chromatography\/prepacked-columns\/affinity-antibody\/hiscreen-mabselect-sure-lx-protein-a-column-p-05738\"\u003eHiScreen MabSelect SuRe LX\u003c\/a\u003e, \u003ca href=\"\/shop\/chromatography\/prepacked-columns\/affinity-antibody\/readytoprocess-mabselect-sure-lx-protein-a-columns-p-09569\"\u003eReadyToProcess MabSelect SuRe LX columns\u003c\/a\u003e, \u003ca href=\"\/shop\/chromatography\/prepacked-columns\/affinity-antibody\/predictor-mabselect-sure-lx-filter-plates-p-05662\"\u003ePreDictor MabSelect SuRe LX\u003c\/a\u003e or \u003ca href=\"\/shop\/chromatography\/prepacked-columns\/affinity-antibody\/predictor-robocolumn-mabselect-sure-lx-p-05665\"\u003ePreDictor Robocolumns MabSelect SuRe LX\u003c\/a\u003e\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-15712-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-29872-pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"25 mL","offer_id":45982024335439,"sku":"17547401","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"200 mL","offer_id":45982024368207,"sku":"17547402","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-10141-original-png_19e2940b-cab1-4b68-9341-adbaca014e7e.png?v=1785957122","url":"https:\/\/www.danyel.co.il\/products\/mabselect-sure-lx-protein-a-resin-17547401","provider":"danyel biotech","version":"1.0","type":"link"}