{"product_id":"mabselect-sure-antibody-purification-resin-17543801","title":"MabSelect SuRe™ antibody purification resin","description":"\u003cp\u003eThe recombinant protein A ligand of Cyitva's MabSelect SuRe ™ has been engineered to withstand 0.1–0.5 M NaOH, enabling efficient cleaning of the chromatography resin.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eIn process-scale applications, this NaOH tolerance extends the lifetime of the resin and allows for the use of rigorous and cost-effective CIP and sanitization protocols.\u003c\/li\u003e\n\u003cli\u003eIn research applications, this NaOH tolerance enables the purification of multiple antibody types with minimized cross-contamination risk.\u003c\/li\u003e\n\u003cli\u003eProtein ligand designed for enhanced protease resistance compared with unmodified protein A leads to lower ligand leakage.\u003c\/li\u003e\n\u003cli\u003eMeets industrial demands in terms of comprehensive technical and regulatory support and security of supply.\u003c\/li\u003e\n\u003cli\u003eAnimal-component free raw materials and manufacturing process.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eMabSelect SuRe resin properties\u003c\/p\u003e\n\n\u003cp\u003eThis resin for monoclonal antibody (mAb) purification contains a rigid, high-flow agarose matrix that delivers excellent pressure\/flow properties. Like many of Cytiva's protein A chromatography resins, MabSelect SuRe™ uses oriented ligand coupling for excellent binding capacity. It exhibits low nonspecific protein binding, thereby decreasing impurity levels in the eluate pool.\u003c\/p\u003e\n\n\u003cp\u003eBenefits of alkali-tolerant protein A ligand\u003c\/p\u003e\n\n\u003cp\u003eMabSelect SuRe™ resin features an engineered, alkali-tolerant rProtein A ligand for mAb purification. The ligand provides greater stability than conventional protein A affinity resins in the alkaline conditions used in cleaning-in-place (CIP) and sanitization protocols. The resin can withstand rigorous CIP and sanitization procedures with 0.1 to 0.5 M NaOH. The enhanced alkali stability of this resin improves process economy and product quality; cleaning can be performed with cost-effective reagents such as sodium hydroxide, eliminating the need for expensive and hazardous cleaning agents such as Gua-HCl.\u003c\/p\u003e\n\n\u003cp\u003eGeneric elution conditions for different mAbs\u003c\/p\u003e\n\n\u003cp\u003eMabSelect SuRe™ resin offers generic elution conditions for different monoclonal antibodies, which is an advantage when designing purification platform processes. This feature is also correlated to the construction of the rProtein A ligand, which has a reduced interaction with the VH3 (Fab) domain present in human antibodies.\u003c\/p\u003e\n\n\u003cp\u003eCompatible empty columns – bioprocess scale\u003c\/p\u003e\n\n\u003cp\u003eFor process-scale applications, Cytiva recommends AxiChrom™ chromatography columns for the MabSelect™ family of products.\u003c\/p\u003e\n\n\u003cp\u003eConvenient prepacked columns – research scale\u003c\/p\u003e\n\n\u003cp\u003eThis chromatography resin is also available in the following formats:\u003c\/p\u003e\n\n\u003cul\u003e\n\t\u003cli\u003eHiTrap™ MabSelect SuRe™: convenient for easy use with a syringe, peristaltic pump, and chromatography system\u003c\/li\u003e\n\t\u003cli\u003eHiScreen™ MabSelect SuRe™ for method and process development\u003c\/li\u003e\n\t\u003cli\u003ePreDictor™ MabSelect SuRe™ 96-well filter plate for high-throughput screening or process development\u003c\/li\u003e\n\t\u003cli\u003ePredDictor™ RoboColumns MabSelect™– miniaturized column format for high-throughput process development\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eConvenient prepacked columns – bioprocess scale\u003c\/p\u003e\n\n\u003cp\u003ePrepacked ReadyToProcess™ columns are available, eliminating the need for column packing and cleaning validation.\u003c\/p\u003e\n\n\u003cp\u003eLearn about prepacked \u003ca href=\"\/shop\/chromatography\/prepacked-columns\/affinity-antibody\/hiscreen-mabselect-sure-protein-a-column-p-05737\"\u003eHiScreen MabSelect SuRe\u003c\/a\u003e, \u003ca href=\"\/shop\/chromatography\/prepacked-columns\/affinity-antibody\/hitrap-mabselect-sure-p-05659\"\u003eHiTrap MabSelect SuRe\u003c\/a\u003e, \u003ca href=\"\/shop\/chromatography\/prepacked-columns\/affinity-antibody\/mabselect-sure-resin-prepacked-in-readytoprocess-single-use-columns-p-05565\"\u003eReadyToProcess MabSelect SuRe columns\u003c\/a\u003e, \u003ca href=\"\/shop\/chromatography\/prepacked-columns\/affinity-antibody\/predictor-mabselect-sure-prepacked-96-well-plates-p-05655\"\u003ePreDictor MabSelect SuRe\u003c\/a\u003e or \u003ca href=\"\/shop\/chromatography\/resins\/affinity-antibody\/predictor-robocolumn-mabselect-sure-p-05739\"\u003ePreDictor Robocolumns MabSelect SuRe\u003c\/a\u003e\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-13584-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-29872-pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"25 mL","offer_id":45982285234255,"sku":"17543801","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"200 mL","offer_id":45982285267023,"sku":"17543802","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-49760-original-png_893c207d-04a5-46bc-a472-53d6acbba583.png?v=1785959916","url":"https:\/\/www.danyel.co.il\/products\/mabselect-sure-antibody-purification-resin-17543801","provider":"danyel biotech","version":"1.0","type":"link"}