{"product_id":"mabselect-protein-a-affinity-resin-17519902","title":"MabSelect™ protein A affinity resin","description":"\u003cp\u003eMabSelect™ resin is a BioProcess™ protein A resin for capturing monoclonal antibodies (mAbs) from large sample volumes.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHigh-flow agarose matrix allows for high flow velocities at production scale enabling the processing of more than 10 000 L of feed in one working day.\u003c\/li\u003e\n\u003cli\u003eOriented coupling of the ligand and optimized matrix gives high dynamic binding capacity, which reduces resin volume requirements.\u003c\/li\u003e\n\u003cli\u003eLow non-specific binding resulting in low levels of impurities in the product eluate pool\u003c\/li\u003e\n\u003cli\u003eBioProcess™ resin supported for industrial applications and well-established in approved processes.\u003c\/li\u003e\n\u003cli\u003eResin fulfills industrial demands for security of supply, robust performance, and regulatory support.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eOptimized for high capacity and throughput\u003c\/p\u003e\n\n\u003cp\u003eThe resin is based on a highly cross-linked agarose matrix with a recombinant protein A ligand. This ligand is engineered to favor an oriented coupling resulting in an affinity resin with enhanced binding capacity for IgG. The hydrophilic nature of the base matrix ensures low levels of non-specific binding leading to low levels of host cell-derived impurities in the elution pool. MabSelect™ resin is optimized for high capacity, throughput and to deliver a product pool that is high in purity and yield.\u003c\/p\u003e\n\n\u003cp\u003eHigh purification factor in a single step\u003c\/p\u003e\n\n\u003cp\u003eThe recombinant Protein A ligand is expressed in \u003ci\u003eE. coli\u003c\/i\u003e and is free of components of mammalian origin. The specificity of binding to the Fc region of IgG is similarto that of native protein A giving a high purification factor in a single step. In addition, the high capacity and the novel base matrix make MabSelect™ resin an excellent choice for purification of mAbs at process scale.\u003c\/p\u003e\n\n\u003cp\u003eSecurity and support\u003c\/p\u003e\n\n\u003cp\u003eAs a member of the BioProcess™ resins range, MabSelect™ resin meets industrial demands with security of supply and comprehensive technical and regulatory support.\u003c\/p\u003e\n\n\u003cp\u003ePrepacked columns and other formats\u003c\/p\u003e\n\n\u003cp\u003eMabSelect™ resin is available in the following formats: \u003c\/p\u003e\n\n\u003cp\u003eProcess development scale – prepacked\u003c\/p\u003e\n\n\u003cul class=\"-font--body\"\u003e\n\t\u003cli\u003eMabSelect™ resin in PreDictor™ plates – 96-well plates for high-throughput screening or process development.\u003c\/li\u003e\n\t\u003cli\u003eMabSelect™ resin in PreDictor™ mini columns – minitiaturized column format for high throughput process development.\u003c\/li\u003e\n\t\u003cli\u003eMabSelect™ resin in HiScreen™ columns – optimized for method and process development.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eLab\/research scale – prepacked for manual purification\u003c\/p\u003e\n\n\u003cp\u003e\u003ca href=\"\/shop\/chromatography\/resins\/affinity-antibody\/hitrap-mabselect-p-06162\"\u003eMabSelect™ resin in HiTrap™ columns\u003c\/a\u003e – for easy use with a syringe, peristaltic pump, or chromatography system.\u003c\/p\u003e\n\n\u003cp\u003eLab\/research scale – prepacked for automated purification and analysis\u003c\/p\u003e\n\n\u003cp\u003e\u003ca href=\"\/shop\/chromatography\/resins\/affinity-antibody\/hitrap-mabselect-p-06162\"\u003eMabSelect™ resin in HiTrap™ columns\u003c\/a\u003e – for easy use with a syringe, peristaltic pump, or chromatography system.\u003c\/p\u003e\n\n\u003cp\u003eProcess scale purification – prepacked\u003c\/p\u003e\n\n\u003cp\u003e\u003ca href=\"\/shop\/chromatography\/resins\/affinity-antibody\/hitrap-mabselect-p-06162\"\u003eMabSelect™ resin in ReadyToProcess™ NS columns\u003c\/a\u003e – 1 L and larger columns for clinical manufacturing that avoid the need for cleaning and cleaning validation.\u003c\/p\u003e\n\n\u003cp\u003eLearn about prepacked \u003ca href=\"\/shop\/chromatography\/prepacked-columns\/affinity-antibody\/hiscreen-mabselect-p-05735\"\u003eMabSelect™ resin in HiScreen™ columns\u003c\/a\u003e, \u003ca href=\"\/shop\/chromatography\/resins\/affinity-antibody\/hitrap-mabselect-p-06162\"\u003eMabSelect™ resin in HiTrap™ columns\u003c\/a\u003e, \u003ca href=\"\/shop\/chromatography\/prepacked-columns\/affinity-antibody\/mabselect-ns-resin-prepacked-in-readytoprocess-single-use-columns-p-05742\"\u003eMabSelect™ resin in ReadyToProcess™ columns\u003c\/a\u003e, \u003ca href=\"\/shop\/chromatography\/prepacked-columns\/affinity-antibody\/predictor-mabselect-prepacked-96-well-plates-p-05734\"\u003eMabSelect™ resin in PreDictor™ plates\u003c\/a\u003e or \u003ca href=\"\/shop\/chromatography\/prepacked-columns\/affinity-antibody\/predictor-robocolumn-mabselect-p-05663\"\u003eMabSelect™ resin in PreDictor™ mini columns\u003c\/a\u003e\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-12118-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/digi-29872-pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"25 mL","offer_id":45982337695823,"sku":"17519901","price":7203.0,"currency_code":"ILS","in_stock":true},{"title":"200 mL","offer_id":45982337728591,"sku":"17519902","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-8734-original-png_d90201e4-6d4e-4ba8-8383-af431a9eb8c6.png?v=1785960263","url":"https:\/\/www.danyel.co.il\/products\/mabselect-protein-a-affinity-resin-17519902","provider":"danyel biotech","version":"1.0","type":"link"}