{"product_id":"mabselect-prisma-x-protein-a-resin-17550103","title":"MabSelect PrismA™ X protein A resin","description":"\u003cp\u003eMabSelect PrismA™ X protein A resin is a high-capacity chromatography resin designed to efficiently capture monoclonal antibodies (mAbs). It features exceptional alkaline stability for repeated cleaning in place (CIP) to reduce bioburden.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eDynamic binding capacity (DBC) higher than 80 g of mAb\/L resin at 6 min residence time (RT), saving on resin and buffer consumption.\u003c\/li\u003e\n\u003cli\u003eExcellent alkaline stability enables efficient cleaning and sanitization using 0.5 to 1.0 M NaOH for improved process  economy and robustness.\u003c\/li\u003e\n\u003cli\u003eWell-established protein A ligand used with several chromatography matrices. Supported by the PrismA ELISA kit for accurate and convenient detection of leached protein A ligand.\u003c\/li\u003e\n\u003cli\u003eDesigned for use in short bed height applications using rapid cycling chromatography (RCC) for improved productivity in the protein A capture step.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eDBC at different residence times\u003c\/p\u003e\n\n\u003cp\u003eThe resin is based on a highly cross-linked agarose base matrix with a median particle (bead) size d\u003csub\u003e50v\u003c\/sub\u003e of 50 μm. The DBC for MabSelect PrismA™ X resin using trastuzumab is excellent. At 6 min, the DBC is 82 mg\/mL for MabSelect PrismA™ X resin and 74 mg\/mL for MabSelect PrismA™ resin. As the high DBC is realized at short RT, the MabSelect PrismA™ X resin is beneficial for use in RCC to further reduce resin volumes to increase grams of mAb produced per liter of resin and decrease overall resin costs.\u003c\/p\u003e\n\n\u003cp\u003eAlkaline-stable protein A ligand\u003c\/p\u003e\n\n\u003cp\u003eWe developed the ligand used in MabSelect PrismA™ X and MabSelect PrismA™ resins to withstand high concentrations of NaOH. The enhanced alkaline stability lets you perform efficient cleaning of the resin using 0.5 to 1.0 M NaOH over many purification cycles, providing long resin lifetime and minimized risk for bioburden incidents.\u003c\/p\u003e\n\n\u003cp\u003eFormats\u003c\/p\u003e\n\n\u003cp\u003eMabSelect PrismA™ X resin is available as bulk resin in 25 mL, 200 mL, 1 L, 5 L, and 10 L containers. The resin can be ordered in prepacked column formats such as HiTrap™ columns (1 and 5 mL), HiScreen™ columns, and on request as production-scale ReadyToProcess™ columns. These formats enable use from lab-scale to commercial-scale manufacturing.\u003c\/p\u003e\n\n\u003cp\u003eCytiva’s mAb toolbox\u003c\/p\u003e\n\n\u003cp\u003eProcess volumes, number of batches, target molecule, impurity profile, and cleaning protocols influence which chromatography resin will be most cost-efficient and productive in a given application. We can support you in a discussion about how to set up your process and to make your process more cost efficient. And with every resin you choose, you have Cytiva quality, an extensive security of supply program, and access to our product knowledge to go along with it. \u003ca href=\"https:\/\/info.cytivalifesciences.com\/pd-antibody-variant-contact-us?extcmp=cy25702-global-bp-pd-proteina-mabselect-prismA-X-ot-web-page-pdf\"\u003eContact us for a productivity discussion\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/rRd9HBdATOqwXvKZgSvsIg-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/29874938.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"Prepacked column \/ 1 × 1 mL","offer_id":45982030987343,"sku":"17550151","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Prepacked column \/ 1 × 4.7 mL","offer_id":45982031020111,"sku":"17550115","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Prepacked column \/ 1 × 5 mL","offer_id":45982031052879,"sku":"17550153","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Prepacked column \/ 5 × 1 mL","offer_id":45982031085647,"sku":"17550152","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Prepacked column \/ 5 × 5 mL","offer_id":45982031118415,"sku":"17550154","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Resin \/ 1 L","offer_id":45982031151183,"sku":"17550103","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Resin \/ 5 L","offer_id":45982031183951,"sku":"17550104","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Resin \/ 25 mL","offer_id":45982031216719,"sku":"17550101","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Resin \/ 200 mL","offer_id":45982031249487,"sku":"17550102","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/3WNfVYcSTkyDtD5fWIB1Aw-original-png_987892a3-0eae-4238-9283-62973b4083ed.png?v=1785957289","url":"https:\/\/www.danyel.co.il\/products\/mabselect-prisma-x-protein-a-resin-17550103","provider":"danyel biotech","version":"1.0","type":"link"}