{"product_id":"lumos-mea-24-plate-m384-tmea-24opt","title":"Lumos MEA 24 Plate","description":"\u003cp\u003e\u003cstrong\u003eLumos MEA 24 Plate\u003c\/strong\u003e — Lumos MEA 24 plate, 16 microelectrodes per well including one large stimulation electrode per well, white polystyrene walls with a transparent SU-8 bottom, includes the Lumos lid, box of 5 plates\u003c\/p\u003e\n\u003cdiv class=\"overview\"\u003e\n\n\u003cdiv\u003e\n\n\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cstrong\u003eCell visualization and assay multiplexing\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe innovative, transparent plate bottom offers additional assay flexibility including cell visualization and assay multiplexing. Bright field imaging enables confirmation of cell spotting accuracy and correlation of cell culture health and connectivity with MEA results. Multiplex fluorescence- or luminescence-based assays with your MEA study to probe complementary end points.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv\u003e\u003cimg alt=\"CytoView Z multiwell plate Neurons on a well\" src=\"https:\/\/www.axionbiosystems.com\/sites\/default\/files\/inline-images\/CytoView%20MEA%20-%20neurons%20over%20electrodes%20V2.jpg\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eOptogenetics to control the pacing or bursting of your cells\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eGenetically modification of cells to express excitatory light-sensitive ion channels, such as channel rhodopsin (ChR2), allows for controlled pacing of cardiomyocyte beating or neural network bursting.\u003c\/p\u003e\n\u003cdiv\u003e\u003cdiv\u003e\n\u003cdiv\u003e\u003ccenter\u003e\u003cimg alt=\"Optgenetics pacing of cells\" src=\"https:\/\/www.axionbiosystems.com\/sites\/default\/files\/inline-images\/Lumos%20MEA%20data%202%20ArchT%20A.jpg\"\u003e\u003c\/center\u003e\u003c\/div\u003e\n\u003cdiv\u003e\u003ccenter\u003e\u003cimg alt=\"Optogenetics neural control\" src=\"https:\/\/www.axionbiosystems.com\/sites\/default\/files\/inline-images\/Lumos%20MEA%20data%202%20ChR2%20B.jpg\"\u003e\u003c\/center\u003e\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003e(A) When expressed in neurons, ArchT suppresses neural activity upon incident green light. (B) Whereas, ChR2 can be used to activate neurons\u003c\/strong\u003e\u003cem\u003e\u003cstrong\u003e in vitro\u003c\/strong\u003e\u003c\/em\u003e\u003cstrong\u003e in response to blue light.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFor cardiomyocytes, cardiac repolarization is intrinsically linked to the beat frequency, both of which are sensitive to pharmacological manipulation. Optogenetic stimulation can be used to control the beat frequency and remove it as a variable, resulting in increased reliability of the repolarization measurement.\u003c\/p\u003e\n\u003cdiv\u003e\u003cdiv\u003e\n\u003cdiv\u003e\u003cimg alt=\"Optogenetics pacing of Pluricyte Cardiomyocytes\" src=\"https:\/\/www.axionbiosystems.com\/sites\/default\/files\/inline-images\/Lumos%20MEA%20data%20v1%20C.jpg\"\u003e\u003c\/div\u003e\n\u003cdiv\u003e\u003cimg alt=\"Field potential duration adapted with each sequential beat rate\" src=\"https:\/\/www.axionbiosystems.com\/sites\/default\/files\/inline-images\/Lumos%20MEA%20data%20v1%20D.jpg\"\u003e\u003c\/div\u003e\n\u003cdiv\u003e\u003cimg alt=\"Typical clinical correction formulas did not accurately predict the FPD\" src=\"https:\/\/www.axionbiosystems.com\/sites\/default\/files\/inline-images\/Lumos%20MEA%20data%20v1%20E.jpg\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003e(C, D) The beat rate of Pluricyte® Cardiomyocytes was increased in a step-wise manner (known as a “chirp” assay). The field potential duration (FPD) adapted with each sequential beat rate increase up to 3 Hz. (E) Typical clinical correction formulas, the Fridericia and Bazzett, did not accurately predict the FPD. However, pacing with the Lumos revealed the cell-specific beat rate correction relationship.\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003c\/div\u003e\n\u003ch2\u003eSpecifications\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\u003cth colspan=\"12\"\u003e\n\u003cp\u003eLumos MEA\u003c\/p\u003e\n\u003cdiv\u003e\u003cstrong\u003eThe Lumos MEA plates combine robustness and assay flexibility of a CytoView MEA plate with white walls and a custom optical lid for optimal light delivery in each well\u003c\/strong\u003e\u003c\/div\u003e\n\u003c\/th\u003e\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003ePlate\u003c\/th\u003e\n\u003ctd\u003eCat No.\u003c\/td\u003e\n\u003ctd\u003eWells\u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cp\u003eElectrode\/\u003cbr\u003ewell\u003c\/p\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cp\u003eElectrode\u003cbr\u003elayout*\u003c\/p\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cp\u003eBottom\u003c\/p\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cp\u003eWalls\u003c\/p\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cp\u003eMaestro Volt\u003c\/p\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cp\u003eMaestro\u003cbr\u003eEdge\u003c\/p\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cp\u003eMaestro\u003cbr\u003ePro\u003c\/p\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cp\u003eMaestro\u003cbr\u003eZ\/ZHT\u003c\/p\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cp\u003eMaestro\u003cbr\u003eOriginal\u003c\/p\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003e\u003cstrong\u003eLumos MEA 24\u003c\/strong\u003e\u003c\/th\u003e\n\u003ctd\u003eM384-tMEA-24OPT\u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cp\u003e24\u003c\/p\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cp\u003e16 PEDOT\u003c\/p\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cimg alt=\"Lumos MEA 24 well plate\" src=\"https:\/\/www.axionbiosystems.com\/sites\/default\/files\/inline-images\/Lumos_MEA_24_v1.png\"\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cp\u003eTransparent\u003c\/p\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cp\u003eWhite\u003c\/p\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003ctd\u003e \u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cp\u003e●\u003c\/p\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cp\u003e●\u003c\/p\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003ctd\u003e \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003e\u003cstrong\u003eLumos MEA 48\u003c\/strong\u003e\u003c\/th\u003e\n\u003ctd\u003eM768-tMEA-48OPT\u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cp\u003e48\u003c\/p\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cp\u003e16 PEDOT\u003c\/p\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cimg alt=\"Lumos MEA 48 well plate\" src=\"https:\/\/www.axionbiosystems.com\/sites\/default\/files\/inline-images\/Lumos_MEA_48_v1.png\"\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cp\u003eTransparent\u003c\/p\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cp\u003eWhite\u003c\/p\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003ctd\u003e \u003c\/td\u003e\n\u003ctd\u003e \u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cp\u003e●\u003c\/p\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cp\u003e●\u003c\/p\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003e\u003cstrong\u003eLumos MEA 96\u003c\/strong\u003e\u003c\/th\u003e\n\u003ctd\u003eM768-tMEA-96OPT\u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cp\u003e96\u003c\/p\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cp\u003e8 PEDOT\u003c\/p\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cimg alt=\"Lumos MEA 96 well plate\" src=\"https:\/\/www.axionbiosystems.com\/sites\/default\/files\/inline-images\/Lumos_MEA_96_v1.png\"\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cp\u003eTransparent\u003c\/p\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cp\u003eWhite\u003c\/p\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003ctd\u003e \u003c\/td\u003e\n\u003ctd\u003e \u003c\/td\u003e\n\u003ctd\u003e\u003ccenter\u003e\u003cp\u003e●\u003c\/p\u003e\u003c\/center\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003ctd\u003e \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.axionbiosystems.com\/sites\/default\/files\/resources\/M384-tMEA-24OPT%20DATASHEET%20v4.pdf\"\u003eLumos MEA 24 - Datasheet\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.axionbiosystems.com\/sites\/default\/files\/resources\/Axion%20Bio%20-%20Lumos%20MEA%2048-flyer.pdf\"\u003eLumos MEA Plate - Brochure\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Axion BioSystems","offers":[{"title":"Default Title","offer_id":46498002665551,"sku":"M384-tMEA-24OPT","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/ProductPage_LumosMEA_550x550_2.jpg?v=1787769810","url":"https:\/\/www.danyel.co.il\/products\/lumos-mea-24-plate-m384-tmea-24opt","provider":"danyel biotech","version":"1.0","type":"link"}