{"product_id":"l-cycloserine-sphingolipid-biosynthesis-inhibitor-tbi2280","title":"L-Cycloserine, Sphingolipid biosynthesis inhibitor","description":"\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eProduct Details\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormal Name:\u003c\/strong\u003e (S)-4-Amino-3-isoxazolidinone\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAlternate Names:\u003c\/strong\u003e L-(-)-Cycloserine; S-Cycloserine\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C\u003csub\u003e3\u003c\/sub\u003eH\u003csub\u003e6\u003c\/sub\u003eN\u003csub\u003e2\u003c\/sub\u003eO\u003csub\u003e2\u003c\/sub\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormula Weight:\u003c\/strong\u003e 102.1\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 339-72-0\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;98%\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormulation:\u003c\/strong\u003e Powder\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in DMSO (up to 20 mg\/ml, warm) or in Water (up to 25 mg\/ml).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStability:\u003c\/strong\u003e ≥ 2 years.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eApplications\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eSphingolipid biosynthesis inhibitor\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eFunctions\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eDown-regulates sphingolipid biosynthesis via inhibition of serine palmitoyltransferase (3-ketodihydrosphingosine synthetase). The L isomer was shown to be 100-fold more potent than the D isomer at inhibition of the brain microsomal enzyme. It is a useful pharmacological agent for lowering sphingolipid levels in cells as well as in animal models. Inhibition of de novo ceramide biosynthesis with L-cycloserine positively affected the senescent phenotype, restoring neuronal signaling and reducing mitochondrial dysfunction in a cortical neuronal model of senescence.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eApplication Procedures\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eFirst dissolved in DMSO (20 mg\/ml) or in Water (25 mg\/ml), then diluted to aqueous buffer. Solutions in DMSO or water may be stored at -20°C for up to 1 month.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 13px; font-weight: 700; text-transform: uppercase;\"\u003e\u003cstrong\u003eResearch use only.\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/tribioscience.com\/wp-content\/uploads\/2024\/09\/TBI2280_L-Cycloserine_datasheet.pdf\"\u003eDatasheet (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/tribioscience.com\/wp-content\/uploads\/2024\/09\/TBI2280_L-Cycloserine_MSDS_2024.pdf\"\u003eMSDS (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"TriBioScience","offers":[{"title":"20 mg","offer_id":45986959687759,"sku":"TBI2280-20MG","price":456.0,"currency_code":"ILS","in_stock":true},{"title":"100 mg","offer_id":45986959720527,"sku":"TBI2280-100MG","price":1276.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/TBI2280.png?v=1782819050","url":"https:\/\/www.danyel.co.il\/products\/l-cycloserine-sphingolipid-biosynthesis-inhibitor-tbi2280","provider":"danyel biotech","version":"1.0","type":"link"}