{"product_id":"kl101-cry1-stabilizer-selective-tbi3907","title":"KL101, CRY1 stabilizer (selective)","description":"\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eProduct Details\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormal Name: \u003c\/strong\u003eN-(2-(2,4-Dimethylphenyl)-2,6-dihydro-4H-thieno[3,4-c]pyrazol-3-yl)-3,4-dimethylbenzamide\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C\u003csub\u003e22\u003c\/sub\u003eH\u003csub\u003e23\u003c\/sub\u003eN\u003csub\u003e3\u003c\/sub\u003eOS\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormula Weight:\u003c\/strong\u003e 377.50\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 396721-89-4\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;98%\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormulation:\u003c\/strong\u003e powder\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in DMSO (up to 25 mg\/ml)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStability:\u003c\/strong\u003e ≥ 1 year.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eApplications\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eCRY1 stabilizer (selective)\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eFunctions\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eAn isoform-selective stabilizer of the circadian clock protein CRY1. It dose-dependently lengthened the circadian period in Bmal1-dLuc and Per2-dLuc reporter cells. KL101 strongly enhanced rosiglitazone-dependent brown adipocyte differentiation revealing the importance of CRY-dependent regulation of energy metabolism and a possible new lead for anti-obesity therapeutics.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eApplication Procedures\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eFirst dissolved in DMSO (up to 25 mg\/ml), then diluted to aqueous buffer.\u003c\/p\u003e\n\u003cp\u003e\u003c!--TBI3907-5MG TBI3907-25MG--\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 13px; font-weight: 700; text-transform: uppercase;\"\u003e\u003cstrong\u003eResearch use only.\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/tribioscience.com\/wp-content\/uploads\/2023\/08\/TBI3907_Data_Sheet-1.pdf\"\u003eDatasheet (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"TriBioScience","offers":[{"title":"5 mg","offer_id":45986658418767,"sku":"TBI3907-5MG","price":573.0,"currency_code":"ILS","in_stock":true},{"title":"25 mg","offer_id":45986658451535,"sku":"TBI3907-25MG","price":2502.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/TBI3907.png?v=1782816209","url":"https:\/\/www.danyel.co.il\/products\/kl101-cry1-stabilizer-selective-tbi3907","provider":"danyel biotech","version":"1.0","type":"link"}