{"product_id":"jervine-hedgehog-inhibitor-tbi2388","title":"Jervine, Hedgehog inhibitor","description":"\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eProduct Details\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormal Name: \u003c\/strong\u003e(3β,23β)-17,23-Epoxy-3-hydroxyveratraman-11-one\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAlternate Names: \u003c\/strong\u003e11-Ketocyclopamine\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C\u003csub\u003e27\u003c\/sub\u003eH\u003csub\u003e39\u003c\/sub\u003eNO\u003csub\u003e3\u003c\/sub\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormula Weight:\u003c\/strong\u003e 425.60\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 469-59-0\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurity: \u003c\/strong\u003e\u0026gt;98%\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormulation:\u003c\/strong\u003e powder\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in DMSO (up to 5 mg\/ml), in DMF (up to 6 mg\/ml), or in Ethanol (up to 20 mg\/ml).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStability:\u003c\/strong\u003e ≥ 2 years.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eApplications\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eHedgehog inhibitor\u003c\/p\u003e\n\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eFunctions\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eInhibitor of Hedgehog signaling (IC50 = 0.5-0.7 µM). Binds directly to Smoothened (Smo). Inhibits the response of target tissues to Sonic hedgehog signaling.  Induces COX-2 overexpression in human erythroleukemia cells.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eApplication Procedures\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eFirst dissolved in DMSO (up to 5 mg\/ml), in DMF (up to 6 mg\/ml), or in Ethanol (up to 20 mg\/ml), then diluted to aqueous buffer. Solutions in DMSO, ethanol or DMF may be stored at -20° for up to 3 months.\u003c\/p\u003e\n\u003cp\u003e\u003c!--TBI2388-5MG TBI2388-25MG--\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 13px; font-weight: 700; text-transform: uppercase;\"\u003e\u003cstrong\u003eResearch use only.\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/tribioscience.com\/wp-content\/uploads\/2023\/08\/TBI2388_Jervine.pdf\"\u003eDatasheet (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"TriBioScience","offers":[{"title":"5 mg","offer_id":45986697674831,"sku":"TBI2388-5MG","price":697.0,"currency_code":"ILS","in_stock":true},{"title":"25 mg","offer_id":45986697707599,"sku":"TBI2388-25MG","price":2787.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/TBI2388.png?v=1782816453","url":"https:\/\/www.danyel.co.il\/products\/jervine-hedgehog-inhibitor-tbi2388","provider":"danyel biotech","version":"1.0","type":"link"}