{"product_id":"ionomycin-calcium-ca2-ionophore-tbi2078","title":"Ionomycin Calcium, Ca2+ ionophore","description":"\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eProduct Details\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFermentation Product: \u003c\/strong\u003efrom Streptomyces conglobatus.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C\u003csub\u003e41\u003c\/sub\u003eH\u003csub\u003e70\u003c\/sub\u003eO\u003csub\u003e9\u003c\/sub\u003e • Ca.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormula Weight:\u003c\/strong\u003e 747.1.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 56092-82-1\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥99%\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormulation:\u003c\/strong\u003e Powder.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in DMSO (10 mg\/ml) or in Ethanol (30 mg\/ml).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e -20℃.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStability:\u003c\/strong\u003e ≥ 2 years.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eApplications\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eCa\u003csup\u003e2+\u003c\/sup\u003e Ionophore.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eFunctions\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eHighly selective nonfluorescent calcium (Ca\u003csup\u003e2+\u003c\/sup\u003e) ionophore. In human neutrophils it induces a rapid rise in cytosolic Ca\u003csup\u003e2+\u003c\/sup\u003e which is due to both release from cytosolic Ca\u003csup\u003e2+\u003c\/sup\u003e stores as well as Ca\u003csup\u003e2+\u003c\/sup\u003e influx. It activates (2 μM) and primes (20-200 nM) neutrophil NADPH oxidase. Down regulates beta-catenin\/Tcf signaling in a colon cancer cell line via suppressing the binding of Tcf to its specific DNA-binding site. In rat hepatoma cells, sub-lethal ionomycin activates the stress response by activating SAPK\/JNK and HSF\/HSE interaction leading to upregulation of HSP70 biosynthesis.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eApplication Procedures\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eIonomycin calcium can be dissolved first in DMSO (10 mg\/ml) or ethanol (30mg\/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 13px; font-weight: 700; text-transform: uppercase;\"\u003e\u003cstrong\u003eResearch use only.\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/tribioscience.com\/wp-content\/uploads\/2026\/04\/TBI2078_Ionomycin-calcium_Datasheet.pdf\"\u003eDatasheet (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/tribioscience.com\/wp-content\/uploads\/2026\/04\/TBI2078_Ionomycin-calcium_MSDS.pdf\"\u003eMSDS (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"TriBioScience","offers":[{"title":"1 mg","offer_id":45986508374095,"sku":"TBI2078-1MG","price":308.0,"currency_code":"ILS","in_stock":true},{"title":"5 mg","offer_id":45986508406863,"sku":"TBI2078-5MG","price":965.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/TBI2078-1.jpg?v=1782812888","url":"https:\/\/www.danyel.co.il\/products\/ionomycin-calcium-ca2-ionophore-tbi2078","provider":"danyel biotech","version":"1.0","type":"link"}