{"product_id":"idimerize-regulated-transcription-system-635081","title":"iDimerize™ Regulated Transcription System","description":"\u003cp\u003eThe iDimerize Regulated Transcription System allows tightly regulated, inducible expression of your gene of interest by the addition of a small molecule to the cell medium. The system includes the iDimerize Regulated Transcription Vector Set 2, which contains a vector that encodes two transcription factor domains (which combine to create the inducible transcription factor), a mammalian expression vector used to express your gene of interest, and a control vector. The system also includes the A\/C Heterodimerizer, the membrane-permeant compound required for induction of gene expression through the heterodimerization of the two transcription factor domains.\u003c\/p\u003e\n\u003ch2\u003eFeatures\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eTightly regulated transcription using iDimerize technology\u003c\/li\u003e\n\u003cli\u003eDose-dependent, small molecule control of transcription\u003c\/li\u003e\n\u003cli\u003eActivation domain is physically separated from the DNA prior to addition of the dimerizer ligand, resulting in low background\u003c\/li\u003e\n\u003cli\u003eA\/C Heterodimerizer is identical to the AP21967 ligand\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eApplications\u003c\/h2\u003e\n\u003cp\u003eInducing gene expression in a ligand-dependent manner\u003cbr\u003eAnalyzing genes that promote cell death, block the cell cycle, or are otherwise toxic\u003cbr\u003eFunctional genomics research Product citations Pomerantz, J. L., Sharp, P. A., \u0026amp; Pabo, C. O. Structure-based design of transcription factors. Science 267(5194),\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.takarabio.com\/documents\/SDS\/635057\/635057-EGHS-EN.pdf\"\u003eSafety Data Sheet (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.takarabio.com\/documents\/User%20Manual\/iDimerize%20Regulated%20Transcription%20System%20User%20Manual\/iDimerize%20Regulated%20Transcription%20System%20User%20Manual_013117.pdf\"\u003eUser Manual (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.takarabio.com\/documents\/Components%20List\/635056-031617.pdf\"\u003eA\/C Heterodimerizer Components List\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.takarabio.com\/documents\/Components%20List\/635081-071812.pdf\"\u003eComponents\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Takara Bio","offers":[{"title":"Each","offer_id":45986063384655,"sku":"635081","price":8702.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/2761_dimerizer_molecular_weight.gif?v=1782802661","url":"https:\/\/www.danyel.co.il\/products\/idimerize-regulated-transcription-system-635081","provider":"danyel biotech","version":"1.0","type":"link"}