{"product_id":"hiscreen-column-with-mabselect-vl-protein-l-resin-17542015","title":"HiScreen™ column with MabSelect™ VL protein L resin","description":"\u003cp\u003eMabSelect™ VL protein L resin in HiScreen™ chromatography columns. A redesigned protein L ligand captures antibody Fabs, bispecifics, and other variants containing a kappa light chain with high binding capacity and improved alkaline stability.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHigh dynamic binding capacity for efficient capture of target molecules.\u003c\/li\u003e\n\u003cli\u003eStable when cleaned with 0.1 M NaOH, reducing risk for bioburden incidents.\u003c\/li\u003e\n\u003cli\u003eProvides good resolution for product-related impurities in the capture of bispecific antibodies.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBuilt for a diversifying pipeline\u003c\/p\u003e\n\n\u003cp\u003eAs the diversity of antibody variants increases, so does the need for \u003ca href=\"\/solutions\/bioprocessing\/products-and-solutions\/downstream-bioprocessing\/protein-a-chromatography-solutions\" target=\"_self\"\u003echromatography resins\u003c\/a\u003e that can capture and purify these variants. As an alternative to protein A, protein L resin can be used to capture antibody Fabs, bispecific antibodies, and other molecules containing kappa variants of the variable light (VL) chain. Protein L binds human kappa light chain subtypes 1, 3, and 4 and mouse kappa light chain subtype 1.\u003c\/p\u003e\n\n\u003cp\u003eRedesigned protein L ligand\u003c\/p\u003e\n\n\u003cp\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/78R6xTZSIUGB4Q5N-TlxQA-pdf\" target=\"_self\"\u003eMabSelect™ VL protein L resin\u003c\/a\u003e showed a two-fold increase in binding capacity compared to our \u003ca href=\"\/shop\/chromatography\/resins\/affinity-antibody\/capto-l-antibody-fragment-purification-resin-p-00629\" target=\"_self\"\u003eCapto™ L chromatography resin\u003c\/a\u003e. This higher capacity provides productivity advantages in research and biomanufacturing.\u003c\/p\u003e\n\n\u003cp\u003eThe MabSelect™ VL protein L resin can withstand cleaning with 0.1 M NaOH, thanks to multimerization and modification of one of the domains of the native protein L ligand.\u003c\/p\u003e\n\n\u003cp\u003eHiScreen™ columns are convenient for method optimization and parameter screening enabled by the 10 cm bed height for efficient chromatography process development. MabSelect™ VL protein L resin is also available in \u003ca href=\"\/shop\/chromatography\/prepacked-columns\/affinity-antibody\/hitrap-mabselect-vl-protein-l-column-p-29317\"\u003e1 mL and 5 mL HiTrap™ prepacked columns\u003c\/a\u003e, \u003ca href=\"\/shop\/chromatography\/resins\/affinity-antibody\/mabselect-vl-protein-l-resin-p-31823\"\u003ebulk resins in different pack sizes\u003c\/a\u003e, \u003ca href=\"\/shop\/chromatography\/prepacked-columns\/affinity-antibody\/predictor-robocolumn-mabselect-vl-protein-l-minicolumns-p-31816\"\u003ePreDictor™ RoboColumn® minicolumns\u003c\/a\u003e, and \u003ca href=\"\/shop\/chromatography\/prepacked-columns\/affinity-antibody\/mabselect-vl-resin-in-readytoprocess-columns-p-32117\"\u003eReadyToProcess™ columns\u003c\/a\u003e for purifying protein as well as screening and process evaluation. \u003ca href=\"https:\/\/info.cytivalifesciences.com\/mabselectVL-launch.html\" target=\"_self\"\u003eContact your Cytiva sales representative\u003c\/a\u003e for more information.\u003c\/p\u003e\n\n\u003cp\u003e\u003ca href=\"\/solutions\/bioprocessing\/knowledge-center\/capture-of-bispecific-antibodies-and-removal-of-product-related-impurities\"\u003eLearn more about capture of bispecific antibodies and removal of product-related impurities using MabSelect™ VL resin.\u003c\/a\u003e\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.cytivalifesciences.com\/api\/public\/content\/78R6xTZSIUGB4Q5N-TlxQA-pdf\"\u003eData file (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/29704871.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"1 × 4.7 mL","offer_id":45982440783951,"sku":"17542015","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/IzfMHEu2y0CdulUCBKsEHw-original-png_b91c017d-d58f-49ed-a873-f953aff68da9.png?v=1785961141","url":"https:\/\/www.danyel.co.il\/products\/hiscreen-column-with-mabselect-vl-protein-l-resin-17542015","provider":"danyel biotech","version":"1.0","type":"link"}