{"product_id":"hedera-profiling-2-ctdna-test-panel-hp2-t18-6lp223ir","title":"Hedera Profiling 2 ctDNA Test Panel (HP2), 32-Gene NGS Liquid Biopsy Kit, 18 Tests","description":"\u003cp\u003eHedera Profiling 2 (HP2) is a targeted 32-gene, hybrid-capture NGS liquid biopsy assay for profiling the most common solid tumors, including lung, breast and colorectal cancers. It detects SNVs, Indels, CNVs, Fusions and MSI from as little as 10 ng of plasma cfDNA and includes more than 80% of the ESCAT Level I genes. 18 tests per kit.\u003c\/p\u003e\u003cp\u003eKits are commercialized together with the Hedera Prime software and can be purchased separately.\u003c\/p\u003e\u003ch2\u003eKey Features\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompact but comprehensive:\u003c\/strong\u003e 32 gene-panel for the detection of SNVs, Indels, CNVs, Fusions and MSI across \u0026gt; 10 most common tumor types in a single, DNA-only liquid biopsy assay\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHighly actionable:\u003c\/strong\u003e \u0026gt;80% of the ESCAT Level I genes are included in the panel including ESR1, METex14 and MSI status\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFast and accurate:\u003c\/strong\u003e Swiftly integrates into your routine NGS workflow to get accurate results with low input material within 5 calendar days, with as little as 10ng of cell-free DNA (30ng input recommended)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRobust software analysis:\u003c\/strong\u003e Backed by Hedera Prime software, save time on each report while ensuring accurate and reliable results\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eUnique fusions detection method on DNA:\u003c\/strong\u003e Cutting-edge proprietary technology to detect fusions in ctDNA with unmatched precision, enhancing the accuracy of complex variants detection in plasma samples\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eWorkflow\u003c\/h2\u003e\u003cp\u003eThe kit integrates into your existing NGS workflow and sequencing instrument; tertiary analysis and reporting run in the Hedera Prime software.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003e3 hours\u003c\/strong\u003e - hands on time\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e5 calendar days\u003c\/strong\u003e - from sample to report\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u0026lt; 5 minutes\u003c\/strong\u003e - tertiary analysis \u0026amp; reporting\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cimg src=\"https:\/\/cdn.prod.website-files.com\/651c4a232949c9f38286a491\/69ddd6e8c9b3a995429e94f5_HP2-workflow.png\" alt=\"Hedera Profiling 2 ctDNA test panel sample-to-report workflow\" style=\"max-width:100%;height:auto\" loading=\"lazy\"\u003e\u003c\/p\u003e\u003ch2\u003eSpecifications\u003c\/h2\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003ePanel size\u003c\/td\u003e\n\u003ctd\u003e90 kb\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNumber of genes\u003c\/td\u003e\n\u003ctd\u003e32\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eInstruments supported\u003c\/td\u003e\n\u003ctd\u003eIllumina NextSeq and NovaSeq Series\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMultiplexing\u003c\/td\u003e\n\u003ctd\u003eup to 6 samples on a NextSeq 500\/550 instrument (MID Output flow cell)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSample size\u003c\/td\u003e\n\u003ctd\u003emin 5 mL plasma required (cfDNA BCT tubes by Streck recommended for blood collection)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ecfDNA input\u003c\/td\u003e\n\u003ctd\u003emin 10ng cfDNA (30ng of cfDNA recommended)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLibrary preparation method\u003c\/td\u003e\n\u003ctd\u003ehybrid-capture chemistry\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eUMI\/UDI technologies\u003c\/td\u003e\n\u003ctd\u003eallowing error correction and preventing index hopping for enhanced sensitivity and specificity\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eReactions per kit\u003c\/td\u003e\n\u003ctd\u003e18\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\u003ch2\u003ePerformance\u003c\/h2\u003e\u003cp\u003e32-gene NGS panel optimized to run samples across all solid tumor types recommended by ESMO for ctDNA testing including the vast majority of ESCAT Level I biomarkers published to date\u003c\/p\u003e\u003cp\u003eHedera Profiling 2 ctDNA test panel includes SNVs, Indels, CNVs, Fusions, and MSI\u003c\/p\u003e\u003cp\u003eThe panel detects a broad range of cfDNA variants as well as Microsatellite Instability (MSI).\u003c\/p\u003e\u003cp\u003eResults from a unique international (8 countries), multicenter (11 centers), analytical validation study\u003c\/p\u003e\u003cp\u003eResults based on 30 ng of input cfDNA (commercial reference control DNA) for all SNVs, Indels and Fusions with samples run on a NextSeq 2000 instrument.\u003c\/p\u003e\u003cp\u003e137 clinical cfDNA samples were run across 9 tumor types (lung, breast, colon, prostate, pancreatic, endometrial \u0026amp; cervical cancers, neuroblastoma, melanoma). Results based on clinical samples run on NextSeq 500\/550\/550Dx and Novaseq 6000 instruments. MSI method preliminarily trained on an additional set of 54 clinical samples.\u003c\/p\u003e\u003cp\u003eHigh observed sensitivity obtained with commercial reference control cfDNA testing is corroborated with real-life cfDNA clinical samples from 11 expert cancer centers\u003c\/p\u003e\u003ch2\u003eGene List\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eTumor types:\u003c\/strong\u003e Lung Cancer, Breast Cancer, Colorectal Cancer, Thyroid Cancer, Gastrointestinal Stromal Tumors (GIST), Cholangiocarcinoma and other solid tumors.\u003c\/p\u003e\u003cp\u003eAKT1, ALK, BRAF, EGFR, ERBB2, ESR1, FGFR1, FGFR2, FGFR3, FGFR4, GNA11, GNAQ, GNAS, HRAS, IDH1, IDH2, KEAP1, KIT, KRAS, MAP2K1, MET, NRAS, NTRK1, NTRK2, NTRK3, PDGFRA, PIK3CA, PTEN, RET, ROS1, STK11, TP53\u003c\/p\u003e\u003ch2\u003eOrdering Information\u003c\/h2\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eSKU\u003c\/th\u003e\n\u003cth\u003eProduct\u003c\/th\u003e\n\u003cth\u003eFormat\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\u003ctr\u003e\n\u003ctd\u003eT18-6LP223IR\u003c\/td\u003e\n\u003ctd\u003eHedera Profiling 2 ctDNA Test Panel (HP2)\u003c\/td\u003e\n\u003ctd\u003e18 tests\u003c\/td\u003e\n\u003c\/tr\u003e\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003e\u003cem\u003eFor performance studies only, not authorized for diagnostic procedures until its clinical performance has been established and all local regulatory requirements for routine testing are met. Not available in all countries including the United States.\u003c\/em\u003e\u003c\/p\u003e","brand":"Hedera Dx","offers":[{"title":"Default Title","offer_id":46798498267215,"sku":"T18-6LP223IR","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/653130a0baed54e0e893b602_n22_201.png?v=1789655462","url":"https:\/\/www.danyel.co.il\/products\/hedera-profiling-2-ctdna-test-panel-hp2-t18-6lp223ir","provider":"danyel biotech","version":"1.0","type":"link"}