{"product_id":"cypher5e-nhs-ester-pa15405","title":"CypHer5E NHS Ester","description":"\u003cp\u003eCypHer5E is a flexible, generic fluorophore that can be used to study most classes of cell surface receptors which internalize into the endocytic pathway when activated by a ligand.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eGeneric technology can be coupled to any receptor or epitope tag antibody.\u003c\/li\u003e\n\u003cli\u003eMonitors any neutral to acidic event.\u003c\/li\u003e\n\u003cli\u003eSimple fluorescence intensity increase.\u003c\/li\u003e\n\u003cli\u003eClassic CyDye profile of two heterocycles linked by a polymethine bridge, and contains secondary nitrogen atoms in one or both heterocyclic rings.\u003c\/li\u003e\n\u003cli\u003eCypHer5E has additional sulfonate groups to enhance its solubility in aqueous solutions.\u003c\/li\u003e\n\u003cli\u003eIncreased labelling efficiency and reduces adverse dye-dye interactions.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eCypHer5E reports ligand-mediated receptor internalization by exploiting pH differences that occur along the endocytic pathway. CypHer5E is a red-excitable, pH-sensitive cyanine dye derivative that is minimally fluorescent at a basic pH and maximally fluorescent at an acidic pH. It is therefore well suited to report the movement of a receptor from the cell surface into acidic endosomes upon agonist stimulation.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/d3.cytivalifesciences.com\/prod\/IFU\/28951572.pdf\"\u003eInstructions for use (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"Cytiva","offers":[{"title":"1 mg","offer_id":45982011490383,"sku":"PA15401","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"5 mg","offer_id":45982011523151,"sku":"PA15405","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/digi-31342-original-png_a3a27ee5-a210-4c1f-aed7-ab201fe701d9.png?v=1785956526","url":"https:\/\/www.danyel.co.il\/products\/cypher5e-nhs-ester-pa15405","provider":"danyel biotech","version":"1.0","type":"link"}