{"product_id":"clodronate-2na-bis-phosphonate-osteoclast-apoptosis-agent-tbi4631","title":"Clodronate 2Na, Bis-phosphonate; Osteoclast apoptosis agent","description":"\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eProduct Details\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormal Name: \u003c\/strong\u003eDichloromethylenediphosphonic acid disodium tetrahydrate\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e CH\u003csub\u003e2\u003c\/sub\u003eCl\u003csub\u003e2\u003c\/sub\u003eO\u003csub\u003e6\u003c\/sub\u003eP\u003csub\u003e2\u003c\/sub\u003e·2Na·\u003csub\u003e4\u003c\/sub\u003eH\u003csub\u003e2\u003c\/sub\u003eO\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormula Weight:\u003c\/strong\u003e 360.92\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 88416-50-6\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;98%\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormulation:\u003c\/strong\u003e Powder\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in water (up to at least 10 mg\/ml)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStability:\u003c\/strong\u003e ≥ 2 years.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eApplications\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eBis-phosphonate; Osteoclast apoptosis agent\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eFunctions\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eClodronate is a first generation non-nitrogenous bisphosphonate drug for the prevention and treatment of osteoporosis and skeletal fractures\/hypercalcemia in patients with cancer.  It strongly binds to hydroxyapatite and directly reduces osteoclast activity. Clodronate is metabolized in vitro to a cytotoxic ATP analog (AppCCl2p) which inhibits ADP\/ATP translocase in the mitochondrial inner membrane leading to osteoclast apoptosis.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eApplication Procedures\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eFirst dissolved in water (up to at least 10 mg\/ml), then diluted to aqueous buffer. Solutions in distilled water may be stored at -20°C for up to 3 months.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c!--TBI4631-10MG TBI4631-50MG--\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 13px; font-weight: 700; text-transform: uppercase;\"\u003e\u003cstrong\u003eResearch use only.\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/tribioscience.com\/wp-content\/uploads\/2023\/06\/TBI4631_Clodronate-2Na.pdf\"\u003eDatasheet (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"TriBioScience","offers":[{"title":"10 mg","offer_id":45986556018767,"sku":"TBI4631-10MG","price":245.0,"currency_code":"ILS","in_stock":true},{"title":"50 mg","offer_id":45986556051535,"sku":"TBI4631-50MG","price":573.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/TBI4631.png?v=1782813981","url":"https:\/\/www.danyel.co.il\/products\/clodronate-2na-bis-phosphonate-osteoclast-apoptosis-agent-tbi4631","provider":"danyel biotech","version":"1.0","type":"link"}