{"product_id":"cisplatin-anticancer-agent-tbi2204","title":"Cisplatin, Anticancer agent","description":"\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eProduct Details\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormal Name: \u003c\/strong\u003eCis-Diaminodichloroplatinum\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAlternate Names: \u003c\/strong\u003eCDDP; cis-Diamineplatinum(II) dichloride\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e Cl\u003csub\u003e2\u003c\/sub\u003eH\u003csub\u003e4\u003c\/sub\u003eN\u003csub\u003e2\u003c\/sub\u003ePt\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormula Weight:\u003c\/strong\u003e 300.05\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 15663-27-1\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;98%\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormulation:\u003c\/strong\u003e powder\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in Water (up to 2.5 mg\/ml with warming).   Note: Compound will dissolve in DMSO, but DMSO inactivates cytotoxicity.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e RT\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStability:\u003c\/strong\u003e ≥ 1 year.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eApplications\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eAnticancer agent\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eFunctions\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eInduces intra- and interstrand DNA adducts which poison topoisomerase I. Synergizes with topoisomerase I inhibitors such as topotecan. Induces apoptosis by sequential activation of caspase-8, -3 and -6 in osteosarcoma cells. Inhibits expression of X-linked inhibitor of apoptosis protein (XIAP) in human LNCaP cells. Numerous mechanisms inhibit propagation of cisplatin-induced DNA damage to signal apoptosis resulting in resistance. Clinically useful anticancer agent.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eApplication Procedures\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eFirst dissolved in Water (up to 2.5 mg\/ml with warming), then diluted to aqueous buffer. Solutions in distilled water are not stable and must be used within 1 working day. do not store solutions.\u003c\/p\u003e\n\u003cp\u003e\u003c!--TBI2204-100MG TBI2204-500MG--\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 13px; font-weight: 700; text-transform: uppercase;\"\u003e\u003cstrong\u003eResearch use only.\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/tribioscience.com\/wp-content\/uploads\/2023\/07\/TBI2204_Cisplatin.pdf\"\u003eDatasheet (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"TriBioScience","offers":[{"title":"100 mg","offer_id":45986583937103,"sku":"TBI2204-100MG","price":409.0,"currency_code":"ILS","in_stock":true},{"title":"500 mg","offer_id":45986583969871,"sku":"TBI2204-500MG","price":1642.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/TBI2204-1.png?v=1782814989","url":"https:\/\/www.danyel.co.il\/products\/cisplatin-anticancer-agent-tbi2204","provider":"danyel biotech","version":"1.0","type":"link"}