{"product_id":"caspase-1-colorimetric-assay-kit-tbs2040","title":"Caspase-1 Colorimetric Assay Kit","description":"\u003cp\u003eApoptosis plays a fundamental role in many normal biological processes as well as in several disease states. Apoptosis can be induced by various stimuli that all produce the same end result: systematic and orderly cell death.\u003c\/p\u003e\n\u003cp\u003eThe inflammasome is a large multiprotein complex whose assembly leads to the activation of caspase-1, which promotes the maturation of proinflammatory cytokines: interleukin-1β (IL-1β) and IL-18.\u003c\/p\u003e\n\u003cp\u003eThe TriboTM Caspase-1 Colorimetric Assay Kits provide a simple and convenient means for assaying the activity of caspases that recognize the sequence YVAD. The assay is based on spectrophotometric detection of the chromophore p- nitroaniline (pNA) after cleavage from the labeled substrate YVAD-pNA. The pNA light emission can be quantified using a spectrophotometer or a microtiter plate reader at 400- or 405-nm. Comparison of the absorbance of pNA from an apoptotic sample with an uninduced control allows the determination of the fold increase in caspase-1 activity.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003eAPPLICATIONS\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eApoptosis\u003c\/li\u003e\n\u003cli\u003eDrug screening\u003c\/li\u003e\n\u003cli\u003eGrowth factors\u003c\/li\u003e\n\u003cli\u003eCytotoxicity\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003eRELATED PRODUCTS\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/tribioscience.com\/product\/life-sciences\/biochemical-assays\/resazurin-cell-viability-kit\/\" target=\"_blank\" rel=\"noopener noreferrer\"\u003eResazurin Cell Viability (TBS2001)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/tribioscience.com\/product\/life-sciences\/biochemical-assays\/ldh-cytotoxicity-assay\/\" target=\"_blank\" rel=\"noopener noreferrer\"\u003eLDH Cytotoxicity Assay (TBS2002)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/tribioscience.com\/product\/life-sciences\/biochemical-assays\/mtt-cell-viability-assay\/\" target=\"_blank\" rel=\"noopener noreferrer\"\u003eMTT Cell Viability Assay (TBS 2003)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/tribioscience.com\/product\/life-sciences\/biochemical-assays\/mts-cell-viability-assay\/\" target=\"_blank\" rel=\"noopener noreferrer\"\u003eMTS Cell Viability Assay (TBS2004)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/tribioscience.com\/product\/life-sciences\/biochemical-assays\/catalase-assay\/\" target=\"_blank\" rel=\"noopener noreferrer\"\u003eCatalase Assay (TBS2006)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c!--TBS2040--\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 13px; font-weight: 700; text-transform: uppercase;\"\u003e\u003cstrong\u003eResearch use only.\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/tribioscience.com\/wp-content\/uploads\/2019\/04\/TBS2040-Caspase1colorimetric_V02-2021.pdf\"\u003eDatasheet (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/tribioscience.com\/wp-content\/uploads\/2019\/04\/TBS2040-Caspase1colorimetric_MSDS_2024-1.pdf\"\u003eMSDS (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"TriBioScience","offers":[{"title":"Default Title","offer_id":45986428223567,"sku":null,"price":0.0,"currency_code":"ILS","in_stock":true}],"url":"https:\/\/www.danyel.co.il\/products\/caspase-1-colorimetric-assay-kit-tbs2040","provider":"danyel biotech","version":"1.0","type":"link"}