{"product_id":"bexarotene-retinoid-rxr-agonist-tbi2121","title":"Bexarotene, Retinoid RXR agonist","description":"\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eProduct Details\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormal Name:\u003c\/strong\u003e 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAlternate Names:\u003c\/strong\u003e LGD-1069; SR-11247\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C\u003csub\u003e24\u003c\/sub\u003eH28O\u003csub\u003e2\u003c\/sub\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormula Weight:\u003c\/strong\u003e 348.49\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 153559-49-0\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;98%\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormulation:\u003c\/strong\u003e powder\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in DMSO (up to 60 mg\/ml) or in Ethanol (up to 10 mg\/ml with warming).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e -20°C\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStability:\u003c\/strong\u003e ≥ 1 year.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eApplications\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eRetinoid RXR agonist\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eFunctions\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eA highly potent and selective retinoid X receptor (RXR) agonist (EC50=28, 25, 20 nM for RXRα, β, γ respectively). Clinically useful antineoplastic agent for cutaneous T-cell lymphoma Causes complete regression of mammary carcinoma. Bexarotene significantly increases clearance of soluble β-amyloid in a mouse Alzheimer′s model and increases cognitive ability. Reverses apoE4-driven brain pathology and behavioral deficits in vivo.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 18px\"\u003e\u003cstrong\u003e\u003cu\u003eApplication Procedures\u003c\/u\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eFirst dissolved in DMSO (up to 60 mg\/ml) or in Ethanol (up to 10 mg\/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 week.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003c!--TBI2121-10MG TBI2121-50MG--\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 13px; font-weight: 700; text-transform: uppercase;\"\u003e\u003cstrong\u003eResearch use only.\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/tribioscience.com\/wp-content\/uploads\/2023\/07\/TBI2121_Bexarotene.pdf\"\u003eDatasheet (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e","brand":"TriBioScience","offers":[{"title":"10 mg","offer_id":45986574794831,"sku":"TBI2121-10MG","price":328.0,"currency_code":"ILS","in_stock":true},{"title":"100 mg","offer_id":45986574827599,"sku":"TBI2121-100MG","price":1477.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/TBI2121.png?v=1782814747","url":"https:\/\/www.danyel.co.il\/products\/bexarotene-retinoid-rxr-agonist-tbi2121","provider":"danyel biotech","version":"1.0","type":"link"}