{"product_id":"archer-variantplex-comprehensive-tissue-and-blood-panel-ngs-assay-ab0200","title":"Archer VARIANTPlex Comprehensive Tissue and Blood Panel","description":"\u003cp\u003e\u003cstrong\u003eIdentify DNA profiles of multiple cancers with one panel\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eEfficiently detect single nucleotide variants, copy number variations, insertions and deletions in 460 genes along with microsatellite instability, tumor mutational burden, and homologous recombination deficiency status with targeted NGS relevant for colorectal, breast, melanoma, gastric, pancreatic, CNS, NSCLC, myeloid, lymphoid, and other pan-cancer research.\u003c\/p\u003e\u003ch2\u003eKey Benefits\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCustomizable content\u003c\/strong\u003e — Combine pre-designed panels, create, and easily add targets to your existing assay with Assay Marketplace , or work directly with a design expert.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDetect confidently\u003c\/strong\u003e — Anchored Multiplex PCR (AMP™) chemistry is designed for compatibility with a wide range of sample types, including low-input and potentially degraded samples such as FFPE tissue. Archer Analysis includes a unique outlier detection algorithm that leverages position-specific data to enable variant detection even at low allele frequencies, empowering you to detect confidently.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAchieve efficiency\u003c\/strong\u003e — Streamlined workflows for your lab are enabled by your choice of reaction-sized lyophilized reagents or high-throughput liquid reagents, while parallel workflows across all Archer panels provide efficient genomic characterization.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003ePanel Specifications\u003c\/h2\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eTargeted genes\u003c\/td\u003e\n\u003ctd\u003e460\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eGenomic alterations\u003c\/td\u003e\n\u003ctd\u003eSNVs, Indels, CNVs, ITD, MSI, TMB, HRD\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eInput nucleic acid required*\u003c\/td\u003e\n\u003ctd\u003e10 ng\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRecommended number of reads\u003c\/td\u003e\n\u003ctd\u003e61 M\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHands-on time\u003c\/td\u003e\n\u003ctd\u003e\u0026lt;3.5 hours\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTotal library prep time\u003c\/td\u003e\n\u003ctd\u003e1.5 days\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePlatform compatibility\u003c\/td\u003e\n\u003ctd\u003eIllumina®\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eReagent format\u003c\/td\u003e\n\u003ctd\u003eLyophilized or liquid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSupported sample types\u003c\/td\u003e\n\u003ctd\u003eFFPE, fresh frozen, cytology smear, FNA\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\u003cp\u003e\u003csmall\u003e*Input mass requirements vary depending on type and quality. Unless the tumor cellularity and sample quality are high, 50 ng of FFPE-derived nucleic acid should be considered the minimum recommendation. If input is not limiting, 200 ng is recommended.\u003c\/small\u003e\u003c\/p\u003e\u003ch2\u003eGene Targets\u003c\/h2\u003e\u003cp\u003eABL1, ABL2, ACVR1, ACVR2A, AKT1, AKT2, AKT3, ALK, ANKRD26, APC, AR, ARAF, ARHGAP35, ARID1A, ARID1B, ARID2, ARID5B, ASXL1, ASXL2, ATM, ATR, ATRX, AURKA, AURKB, AXIN1, AXIN2, AXL, B2M, BAP1, BARD1, BCL2, BCL2L1, BCL2L11, BCL6, BCOR, BCORL1, BIRC3, BLM, BMPR1A, BRAF, BRCA1, BRCA2, BRIP1, BTG1, BTG2, BTK, CACNA1A, CALR, CARD11, CASP8, CBFB, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CCNE1, CD28, CD70, CD79A, CD79B, CD274, CDC25C, CDC73, CDH1, CDK4, CDK6, CDK8, CDK12, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CEBPA, CHD1, CHD3, CHD4, CHD8, CHEK1, CHEK2, CIC, COL5A1, CREBBP, CRKL, CSDE1, CSF1R, CSF3R, CTCF, CTLA4, CTNNA1, CTNNB1, CUL3, CUX1, CXCR4, CYSLTR2, DAXX, DCK, DDR2, DDX3X, DDX41, DHX15, DICER1, DMD, DNMT3A, DOT1L, EEF1A1, EEF2, EGFR, EGR3, EIF1AX, ELF3, EP300, EPAS1, EPCAM, EPHA2, EPHA3, EPHA7, EPHB1, ERBB2, ERBB3, ERBB4, ERCC1, ERCC2, ERCC4, ERG, ERRFI1, ESR1, ETNK1, ETV6, EWSR1, EZH2, FAM46C, FAM46D, FAM175A, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FAT1, FBXW7, FGF1, FGF2, FGF3, FGF4, FGF7, FGF8, FGF9, FGF19, FGFR1, FGFR2, FGFR3, FGFR4, FH, FLCN, FLNA, FLT1, FLT3, FLT4, FOXA1, FOXA2, FOXL2, FOXO1, FOXP1, FOXQ1, FUBP1, GATA1, GATA2, GATA3, GEN1, GLI1, GNA11, GNA13, GNAQ, GNAS, GPS2, GRIN2D, GRM3, H3F3A, H3F3B, H3F3C, HGF, HIST1H1C, HIST1H1E, HIST1H2BD, HIST1H3B, HIST1H3C, HNF1A, HOXB13, HRAS, HUWE1, ID3, IDH1, IDH2, IGF1R, IKBKE, IKZF1, IL6ST, IL7R, INPP4B, INPPL1, IRF2, IRF4, IRF6, IRS2, JAK1, JAK2, JAK3, JUN, KANSL1, KDM5A, KDM5C, KDM6A, KDR, KEAP1, KEL, KIF1A, KIT, KLF2, KLF4, KLF5, KMT2A, KMT2B, KMT2C, KMT2D, KRAS, KRT222, LAMP1, LATS1, LATS2, LEMD2, LRP1B, LUC7L2, LZTR1, MACF1, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAP3K4, MAP3K13, MAPK1, MAX, MCL1, MDM2, MDM4, MECOM, MED12, MEF2B, MEN1, MET, MGA, MGMT, MITF, MLH1, MLLT3, MPL, MRE11A, MSH2, MSH3, MSH6, MST1R, MTOR, MUC6, MUC16, MUTYH, MYC, MYCL, MYCN, MYD88, MYH9, NBN, NCOR1, NF1, NF2, NFE2L2, NFKBIA, NFKBIE, NIPBL, NKX2-1, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NPM1, NRAS, NSD1, NTRK1, NTRK2, NTRK3, NUP93, PALB2, PARP1, PAX5, PAX8, PBRM1, PDCD1, PDCD1LG2, PDGFRA, PDGFRB, PGR, PHF6, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIM1, PLCB4, PLCG1, PLCG2, PLXNB2, PMS1, PMS2, POLD1, POLE, POLQ, POLRMT, PPARG, PPM1D, PPP2R1A, PPP2R2A, PPP6C, PRDM1, PRKAR1A, PRKD1, PRKDC, PSIP1, PTCH1, PTEN, PTMA, PTPDC1, PTPN11, PTPRC, PTPRD, PTPRT, RAC1, RAD21, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RAD52, RAD54L, RAF1, RARA, RASA1, RB1, RBBP6, RBM10, RECQL4, REL, RET, RHEB, RHOA, RICTOR, RIT1, RNF43, ROS1, RPL5, RPS6KB1, RPS14, RPTOR, RRAS2, RUNX1, RUNX1T1, RXRA, SAMD9, SAMD9L, SCAF4, SDHA, SDHB, SDHC, SDHD, SETBP1, SETD2, SF3B1, SH2B3, SH2D1A, SLC29A1, SLX4, SMAD2, SMAD3, SMAD4, SMARCA4, SMARCB1, SMC1A, SMC3, SMO, SOCS1, SOX2, SOX9, SOX17, SPEN, SPOP, SPTA1, SPTAN1, SRC, SRSF2, STAG1, STAG2, STAT3, STAT5B, STAT6, STK11, SUFU, SYK, TAF1, TBL1XR1, TBX3, TCEB1, TCF3, TCF7L2, TERT, TET1, TET2, TFRC, TGFBR1, TGFBR2, TGIF1, THRAP3, TLR4, TMSB4X, TNFAIP3, TNFRSF14, TP53, TP63, TRAF2, TRAF3, TRAF7, TSC1, TSC2, TSHR, TXNIP, U2AF1, U2AF2, UBA1, UNCX, USP9X, VHL, WT1, XPO1, XRCC2, XRCC3, ZBTB20, ZFHX3, ZMYM2, ZMYM3, ZNF750, ZRSR2\u003c\/p\u003e\u003ch2\u003eDocuments\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eUser guides and protocols\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/sfvideo.blob.core.windows.net\/sitefinity\/docs\/default-source\/protocol\/protocol-variantplex-lac-or-illumina-ra-doc-470rev01.pdf?sfvrsn=59eff007_11\" target=\"_blank\" rel=\"noopener\"\u003eVARIANTPlex-LAC Protocol for Illumina (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/sfvideo.blob.core.windows.net\/sitefinity\/docs\/default-source\/protocol\/variantplex-ht-protocol-for-illumina-protocol.pdf?sfvrsn=b8a5f507_26\" target=\"_blank\" rel=\"noopener\"\u003eVARIANTPlex-HT Protocol for Illumina (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/sfvideo.blob.core.windows.net\/sitefinity\/docs\/default-source\/protocol\/variantplex-hs-hgc-protocol-for-illumina-protocol.pdf?sfvrsn=ba2f507_21\" target=\"_blank\" rel=\"noopener\"\u003eVARIANTPlex HS-HGC Protocol for Illumina (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eProduct inserts\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/sfvideo.blob.core.windows.net\/sitefinity\/docs\/default-source\/supplementary-product-info\/variantplex-ht-comprehensive-tissue-blood-product-insert.pdf?sfvrsn=50e2ce07_6\" target=\"_blank\" rel=\"noopener\"\u003eVARIANTPlex-HT Comprehensive Tissue \u0026amp; Blood Product Insert (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/sfvideo.blob.core.windows.net\/sitefinity\/docs\/default-source\/supplementary-product-info\/variantplex-comprehensive-tissue-blood-product-insert.pdf?sfvrsn=52e2ce07_6\" target=\"_blank\" rel=\"noopener\"\u003eVARIANTPlex Comprehensive Tissue \u0026amp; Blood Product Insert (PDF)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003ePosters\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\u003cli\u003e\u003ca href=\"https:\/\/sfvideo.blob.core.windows.net\/sitefinity\/docs\/default-source\/poster\/comprehensive-genomic-profiling-using-variantplex-and-fusionplex-panels-along-with-archer-s-new-tumor-only-homologous-recombination-deficiency-algorithm-poster.pdf?sfvrsn=9d0bca07_8\" target=\"_blank\" rel=\"noopener\"\u003eComprehensive genomic profiling using VARIANTPlex and FUSIONPlex panels along with Archer’s new tumor-only homologous recombination deficiency algorithm poster (PDF)\u003c\/a\u003e\u003c\/li\u003e\u003c\/ul\u003e\u003ch2\u003eOrdering Information\u003c\/h2\u003e\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eCat. #\u003c\/th\u003e\n\u003cth\u003eKit\u003c\/th\u003e\n\u003cth\u003eFormat\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\u003ctr\u003e\n\u003ctd\u003eAB0200\u003c\/td\u003e\n\u003ctd\u003eVARIANTPlex-HGC 2.0 Comp. Tissue \u0026amp; Blood ILMN 8rxn\u003c\/td\u003e\n\u003ctd\u003eHGC 2.0 \/ Illumina \/ 8 rxn\u003c\/td\u003e\n\u003c\/tr\u003e\u003c\/tbody\u003e\n\u003c\/table\u003e\u003cp\u003e\u003csmall\u003eHT kits are liquid reagents for high-throughput \/ automated workflows (Illumina only). For research use only. Not for use in diagnostic procedures.\u003c\/small\u003e\u003c\/p\u003e","brand":"Archer","offers":[{"title":"HGC 2.0 \/ Illumina \/ 8 rxn","offer_id":46798466678863,"sku":"AB0200","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/variantplex-ht-dx-liquid-reagents_10029100_850_a2042468-4648-4149-929c-d6799a3c2bf0.jpg?v=1789654398","url":"https:\/\/www.danyel.co.il\/products\/archer-variantplex-comprehensive-tissue-and-blood-panel-ngs-assay-ab0200","provider":"danyel biotech","version":"1.0","type":"link"}