{"title":"MALS","description":null,"products":[{"product_id":"wyatt-dawn-8-multi-angle-light-scattering-detector","title":"DAWN 8 Multi-Angle Light Scattering Detector","description":"\u003cspan\u003e\u003cp align=\"center\"\u003e\u003cimg fetchpriority=\"high\" src=\"https:\/\/www.wyatt.com\/wp-content\/uploads\/2019\/10\/DAWN-Hero-Neon-9-19.jpg\" width=\"55%\"\u003e\u003c\/p\u003e\u003c\/span\u003e\n\u003cbr\u003e\n\u003cp\u003eThe world's most advanced light scattering instrument for absolute characterization of proteins, conjugates, macromolecules, and nanoparticles.\u003c\/p\u003e\n\u003cp\u003ePremier MALS\u003c\/p\u003e\n\u003cp\u003eThe DAWN instrument is the premier Multi-Angle static Light Scattering (MALS) detector for absolute characterization of the molar mass and size of macromolecules and nanoparticles in solution. It offers the highest sensitivity, the widest range of molecular weight, size, and concentration, and the largest selection of configurations and optional modules for enhanced capabilities.\u003c\/p\u003e\n\u003chr class=\"no_line\" style=\"margin: 0 auto 10px auto\"\u003e\n\u003cp\u003eSeparation First\u003c\/p\u003e\n\u003cp\u003eMALS is most often used in conjunction with a separation system such as Gel Permeation Chromatography (GPC-MALS), Size Exclusion Chromatography (SEC-MALS), or Field-Flow Fractionation (FFF-MALS) to determine distributions of mass, size, and composition, independent of column calibration by reference standards. \u003c\/p\u003e\n\u003chr class=\"no_line\" style=\"margin: 0 auto 10px auto\"\u003e\n\u003cp\u003eSupported by ASTRA\u003csup\u003e™\u003c\/sup\u003e Software\u003c\/p\u003e\nASTRA Software and its built-in analysis modules support the DAWN MALS instrument, providing the most versatile analysis available for online multi-angle and dynamic light scattering measurements. \n\u003cp\u003eOverview\u003c\/p\u003e\n\u003cp\u003eThe DAWN and its companion \u003ca href=\"https:\/\/www.wyatt.com\/products\/instruments\/optilab-refractive-index-detector.html\"\u003eOptilab\u003csup\u003e™\u003c\/sup\u003e\u003c\/a\u003e dRI detector are the established benchmarks for MALS analysis, cited in thousands of peer-reviewed publications. Multi-angle light scattering detection is indispensable for use with GPC and HPLC-SEC in order to obtain reliable molecular mass distributions and information on molecular conformation, branching ratio, fragments and aggregates.\u003c\/p\u003e\n\u003cp\u003eSEC-MALS with a DAWN and Optilab characterizes conformation and branching of \u003cb\u003esynthetic and natural polymers\u003c\/b\u003e larger than 10 nm in rms radius \u003ci\u003eR\u003c\/i\u003e\u003csub\u003eg\u003c\/sub\u003e. The addition of a \u003ca href=\"https:\/\/www.wyatt.com\/products\/instruments\/viscostar-online-differential-viscometer.html\"\u003eViscoStar\u003csup\u003e™\u003c\/sup\u003e\u003c\/a\u003e differential viscometer creates a GPC triple-detection system that can analyze molecular conformation and size below the \u003ci\u003eR\u003c\/i\u003e\u003csub\u003eg\u003c\/sub\u003e limit of 10 nm and determine Mark-Houwink Sakurada coefficients.\u003c\/p\u003e\n\u003cp\u003eThe combination of a UV\/Vis absorbance detector with a DAWN instrument and Optilab refractive index detector creates a UV-MALS-RI triple-detection system, for analysis of copolymers and protein conjugates (glycoproteins, PEGylated proteins, surfactant-bound membrane proteins, etc.). With the addition of a \u003ca href=\"https:\/\/store.wyatt.com\/shop\/udawn\/udawn3\/wiq\/\"\u003eWyattQELS\u003csup\u003e™\u003c\/sup\u003e DLS module\u003c\/a\u003e for size determination, protein conformation may be analyzed.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ci\u003eM\u003c\/i\u003e\u003csub\u003ew\u003c\/sub\u003e from 200 Da to 1000 MDa\u003c\/li\u003e\n\u003cli\u003eSensitivity: 10 ng\/mL 100 kDa polystyrene in THF, 0.4 µg\/mL BSA (66.4 kDa) in PBS\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ci\u003eR\u003c\/i\u003e\u003csub\u003eg\u003c\/sub\u003e from 10 to 500 nm, up to 1000 nm with shape-specific models\u003c\/li\u003e\n\u003cli\u003eUltra-stable, high-power laser\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThe DAWN may also be used in batch (off-line) mode to characterize the weight-average molar mass, z-average size \n  and second virial coefficient of unfractionated samples.\u003c\/p\u003e\n\u003cp\u003eIn conjunction with a \n  \u003ca href=\"https:\/\/www.wyatt.com\/products\/instruments\/calypso-ii-label-free-biomolecular-interactions.html\"\u003eCalypso\u003csup\u003e™\u003c\/sup\u003e   CG-MALS\u003c\/a\u003e system, the DAWN characterizes macromolecular interactions, label-free and immobilization-free: affinity and absolute stoichiometry of self- and hetero-association of simple or complex molecular systems. The Calypso system also automates the determination of second virial coefficients, cross virial coefficients, average molar masses and sizes.\u003c\/p\u003e\n\u003cp\u003eUltrasonic Cleaning Included\u003c\/p\u003e\n\u003cp\u003eEach DAWN instrument includes an embedded \u003ca href=\"https:\/\/www.wyatt.com\/accessories\/comet.html\"\u003e\u003cb\u003eCOMET\u003csup\u003e™\u003c\/sup\u003e\u003c\/b\u003e\u003c\/a\u003e ultrasonic transducer that cleans the flow cell automatically by agitating the fluid and loosening particles from the glass surfaces. \u003c\/p\u003e\n\u003cp\u003eTemperature-Controlled Models\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAmbient model\u003c\/li\u003e\n\u003cli\u003eUltra-High-Temperature (UHT) model, from ambient up to +210 °C\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003eStandard Peltier heated\/cooled (H\/C) model, temperature control from -15 °C to +150 °C\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eSpecifications\u003c\/h2\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMolar Mass Range\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e200 Da to 1 GDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMolecular Size Range ( R g )\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e≈ 10 to 500 nm, up to 1000 nm with shape-specific models\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMolecular Size Range ( R h )\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eIn flow mode, 0.5 nm to 300 nm ; batch mode 0.5 nm to 1 μm (requires WyattQELS DLS module or DynaPro NanoStar + fiber optic connection).\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSensitivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e10 ng of 100 kDa polystyrene in THF or 200 ng of BSA in PBS, assuming standard 7.8 mm x 300 mm SEC column and no post-column filter\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMobile Phase Compatibility\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eAll-solvent compatible (aqueous and organic). Wetted materials are 316 stainless steel, fused silica or F2 glass, and Kalrez.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMALS Detectors\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eHigh-gain, high dynamic range photodiodes at 18 detection angles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eAuxiliary Detectors\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eLaser monitor for stabilization feedback; forward transmission monitor to correct signals for absorbing samples and to assess data quality.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDynamic Range\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e3,300,000:1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDLS Detector (optional)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eWyattQELS dynamic light scattering module installs directly inside the DAWN chassis. Alternatively, the optical fiber pickup of the DynaPro NanoStar cuvette-based DLS instrument or Mobius DLS-ELS instrument may be installed in the DAWN.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eLaser Wavelength\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e658 nm ± 4 nm; 785 nm optional for use with fluorescing samples\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eLaser Power Control\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eProgrammable 10% to 100%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eFlow Cells\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eFused Silica, optimal for solvent refractive index less than 1.50; F2, optimal for solvent refractive index above 1.50\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eTemperature Options\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eAmbient Heated\/Cooled (HC) -15 °C to +150 °C Ultra-High-Temperature (UHT) ambient to +210 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eAnalog Inputs\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e4 differential analog inputs with 24 bit resolution. Input range -10 V to +10 V\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eAnalog Outputs\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e2 analog outputs from user selectable measurements channels -10 V to +10 V\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eOther Inputs\/Outputs\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eAlarm in, Alarm out\/retransmit, Auto-Inject in, Auto inject contact closure retransmit, Recycle In\/Out (operates Orbit recycle valve)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eComputer Interface\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eEthernet\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eFront Panel Display\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e10.1\" (257 mm), capacitive high-resolution screen with multi-touch functionality, displays signals, graphs, instrument settings and diagnostics\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDimensions\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e58 cm (L) x 36 cm (W) x 26 cm (H)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.wyatt.com\/products\/dawn-brochure-request.html\" target=\"_blank\"\u003eBrochure\u003c\/a\u003e\u003c\/p\u003e","brand":"Wyatt Technology","offers":[{"title":"Ambient \/ Fused Silica, 658 nm \/ None","offer_id":46488395481167,"sku":"WD38-016500","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica, 658 nm \/ WyattQELS","offer_id":46488407834703,"sku":"WD38-016501","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica, 658 nm \/ DLS Fiber","offer_id":46488407867471,"sku":"WD38-0165DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica, 785 nm \/ None","offer_id":46488407900239,"sku":"WD38-017800","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica, 785 nm \/ WyattQELS","offer_id":46488407933007,"sku":"WD38-017801","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica, 785 nm \/ DLS Fiber","offer_id":46488407965775,"sku":"WD38-0178DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica, Aqueous, 658 nm \/ None","offer_id":46488407998543,"sku":"WD38-01AQ6500","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica, Aqueous, 658 nm \/ WyattQELS","offer_id":46488408031311,"sku":"WD38-01AQ6501","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica, Aqueous, 658 nm \/ DLS Fiber","offer_id":46488408064079,"sku":"WD38-01AQ65DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica + Wide-Bore, 658 nm \/ WyattQELS","offer_id":46488408096847,"sku":"WD38-01036501","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica + Wide-Bore, 658 nm \/ DLS Fiber","offer_id":46488408129615,"sku":"WD38-010365DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Wide-Bore Fused Silica, 658 nm \/ WyattQELS","offer_id":46488408162383,"sku":"WD38-036501","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Wide-Bore Fused Silica, 658 nm \/ DLS Fiber","offer_id":46488408195151,"sku":"WD38-0365DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ 2 × Wide-Bore Fused Silica, 658 nm \/ WyattQELS","offer_id":46488408227919,"sku":"WD38-03036501","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ 2 × Wide-Bore Fused Silica, 658 nm \/ DLS Fiber","offer_id":46488408260687,"sku":"WD38-030365DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ To be specified \/ To be specified","offer_id":46488408293455,"sku":"WD38","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Heated\/Cooled \/ Fused Silica, 658 nm \/ None","offer_id":46488395513935,"sku":"WD3HC8-016500","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Heated\/Cooled \/ Fused Silica, 658 nm \/ WyattQELS","offer_id":46488408326223,"sku":"WD3HC8-016501","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Heated\/Cooled \/ Fused Silica, 658 nm \/ DLS Fiber","offer_id":46488408358991,"sku":"WD3HC8-0165DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Heated\/Cooled \/ To be specified \/ To be specified","offer_id":46488408391759,"sku":"WD3HC8","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Temperature Regulated \/ Fused Silica, 658 nm \/ None","offer_id":46488395546703,"sku":"WD3TR8-016500","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Temperature Regulated \/ Fused Silica, 658 nm \/ WyattQELS","offer_id":46488408424527,"sku":"WD3TR8-016501","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Temperature Regulated \/ Fused Silica, 658 nm \/ DLS Fiber","offer_id":46488408457295,"sku":"WD3TR8-0165DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Temperature Regulated \/ To be specified \/ To be specified","offer_id":46488408490063,"sku":"WD3TR8","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ultra-High Temperature \/ To be specified \/ To be specified","offer_id":46488408522831,"sku":"WD3UH8","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/DAWN-Hero-Neon-9-19_ec09b7e7-d1cb-4312-92a5-e60c5d7ceefb.jpg?v=1787675350"},{"product_id":"wyatt-dawn-multi-angle-light-scattering-detector","title":"DAWN Multi-Angle Light Scattering Detector","description":"\u003cspan\u003e\u003cp align=\"center\"\u003e\u003cimg fetchpriority=\"high\" src=\"https:\/\/www.wyatt.com\/wp-content\/uploads\/2019\/10\/DAWN-Hero-Neon-9-19.jpg\" width=\"55%\"\u003e\u003c\/p\u003e\u003c\/span\u003e\n\u003cbr\u003e\n\u003cp\u003eThe world's most advanced light scattering instrument for absolute characterization of proteins, conjugates, macromolecules, and nanoparticles.\u003c\/p\u003e\n\u003cp\u003ePremier MALS\u003c\/p\u003e\n\u003cp\u003eThe DAWN instrument is the premier Multi-Angle static Light Scattering (MALS) detector for absolute characterization of the molar mass and size of macromolecules and nanoparticles in solution. It offers the highest sensitivity, the widest range of molecular weight, size, and concentration, and the largest selection of configurations and optional modules for enhanced capabilities.\u003c\/p\u003e\n\u003chr class=\"no_line\" style=\"margin: 0 auto 10px auto\"\u003e\n\u003cp\u003eSeparation First\u003c\/p\u003e\n\u003cp\u003eMALS is most often used in conjunction with a separation system such as Gel Permeation Chromatography (GPC-MALS), Size Exclusion Chromatography (SEC-MALS), or Field-Flow Fractionation (FFF-MALS) to determine distributions of mass, size, and composition, independent of column calibration by reference standards. \u003c\/p\u003e\n\u003chr class=\"no_line\" style=\"margin: 0 auto 10px auto\"\u003e\n\u003cp\u003eSupported by ASTRA\u003csup\u003e™\u003c\/sup\u003e Software\u003c\/p\u003e\nASTRA Software and its built-in analysis modules support the DAWN MALS instrument, providing the most versatile analysis available for online multi-angle and dynamic light scattering measurements. \n\u003cp\u003eOverview\u003c\/p\u003e\n\u003cp\u003eThe DAWN and its companion \u003ca href=\"https:\/\/www.wyatt.com\/products\/instruments\/optilab-refractive-index-detector.html\"\u003eOptilab\u003csup\u003e™\u003c\/sup\u003e\u003c\/a\u003e dRI detector are the established benchmarks for MALS analysis, cited in thousands of peer-reviewed publications. Multi-angle light scattering detection is indispensable for use with GPC and HPLC-SEC in order to obtain reliable molecular mass distributions and information on molecular conformation, branching ratio, fragments and aggregates.\u003c\/p\u003e\n\u003cp\u003eSEC-MALS with a DAWN and Optilab characterizes conformation and branching of \u003cb\u003esynthetic and natural polymers\u003c\/b\u003e larger than 10 nm in rms radius \u003ci\u003eR\u003c\/i\u003e\u003csub\u003eg\u003c\/sub\u003e. The addition of a \u003ca href=\"https:\/\/www.wyatt.com\/products\/instruments\/viscostar-online-differential-viscometer.html\"\u003eViscoStar\u003csup\u003e™\u003c\/sup\u003e\u003c\/a\u003e differential viscometer creates a GPC triple-detection system that can analyze molecular conformation and size below the \u003ci\u003eR\u003c\/i\u003e\u003csub\u003eg\u003c\/sub\u003e limit of 10 nm and determine Mark-Houwink Sakurada coefficients.\u003c\/p\u003e\n\u003cp\u003eThe combination of a UV\/Vis absorbance detector with a DAWN instrument and Optilab refractive index detector creates a UV-MALS-RI triple-detection system, for analysis of copolymers and protein conjugates (glycoproteins, PEGylated proteins, surfactant-bound membrane proteins, etc.). With the addition of a \u003ca href=\"https:\/\/store.wyatt.com\/shop\/udawn\/udawn3\/wiq\/\"\u003eWyattQELS\u003csup\u003e™\u003c\/sup\u003e DLS module\u003c\/a\u003e for size determination, protein conformation may be analyzed.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ci\u003eM\u003c\/i\u003e\u003csub\u003ew\u003c\/sub\u003e from 200 Da to 1000 MDa\u003c\/li\u003e\n\u003cli\u003eSensitivity: 10 ng\/mL 100 kDa polystyrene in THF, 0.4 µg\/mL BSA (66.4 kDa) in PBS\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ci\u003eR\u003c\/i\u003e\u003csub\u003eg\u003c\/sub\u003e from 10 to 500 nm, up to 1000 nm with shape-specific models\u003c\/li\u003e\n\u003cli\u003eUltra-stable, high-power laser\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThe DAWN may also be used in batch (off-line) mode to characterize the weight-average molar mass, z-average size \n  and second virial coefficient of unfractionated samples.\u003c\/p\u003e\n\u003cp\u003eIn conjunction with a \n  \u003ca href=\"https:\/\/www.wyatt.com\/products\/instruments\/calypso-ii-label-free-biomolecular-interactions.html\"\u003eCalypso\u003csup\u003e™\u003c\/sup\u003e   CG-MALS\u003c\/a\u003e system, the DAWN characterizes macromolecular interactions, label-free and immobilization-free: affinity and absolute stoichiometry of self- and hetero-association of simple or complex molecular systems. The Calypso system also automates the determination of second virial coefficients, cross virial coefficients, average molar masses and sizes.\u003c\/p\u003e\n\u003cp\u003eUltrasonic Cleaning Included\u003c\/p\u003e\n\u003cp\u003eEach DAWN instrument includes an embedded \u003ca href=\"https:\/\/www.wyatt.com\/accessories\/comet.html\"\u003e\u003cb\u003eCOMET\u003csup\u003e™\u003c\/sup\u003e\u003c\/b\u003e\u003c\/a\u003e ultrasonic transducer that cleans the flow cell automatically by agitating the fluid and loosening particles from the glass surfaces. \u003c\/p\u003e\n\u003cp\u003eTemperature-Controlled Models\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAmbient model\u003c\/li\u003e\n\u003cli\u003eUltra-High-Temperature (UHT) model, from ambient up to +210 °C\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003eStandard Peltier heated\/cooled (H\/C) model, temperature control from -15 °C to +150 °C\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eSpecifications\u003c\/h2\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMolar Mass Range\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e200 Da to 1 GDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMolecular Size Range ( R g )\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e≈ 10 to 500 nm, up to 1000 nm with shape-specific models\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMolecular Size Range ( R h )\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eIn flow mode, 0.5 nm to 300 nm ; batch mode 0.5 nm to 1 μm (requires WyattQELS DLS module or DynaPro NanoStar + fiber optic connection).\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSensitivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e10 ng of 100 kDa polystyrene in THF or 200 ng of BSA in PBS, assuming standard 7.8 mm x 300 mm SEC column and no post-column filter\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMobile Phase Compatibility\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eAll-solvent compatible (aqueous and organic). Wetted materials are 316 stainless steel, fused silica or F2 glass, and Kalrez.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMALS Detectors\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eHigh-gain, high dynamic range photodiodes at 18 detection angles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eAuxiliary Detectors\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eLaser monitor for stabilization feedback; forward transmission monitor to correct signals for absorbing samples and to assess data quality.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDynamic Range\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e3,300,000:1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDLS Detector (optional)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eWyattQELS dynamic light scattering module installs directly inside the DAWN chassis. Alternatively, the optical fiber pickup of the DynaPro NanoStar cuvette-based DLS instrument or Mobius DLS-ELS instrument may be installed in the DAWN.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eLaser Wavelength\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e658 nm ± 4 nm; 785 nm optional for use with fluorescing samples\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eLaser Power Control\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eProgrammable 10% to 100%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eFlow Cells\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eFused Silica, optimal for solvent refractive index less than 1.50; F2, optimal for solvent refractive index above 1.50\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eTemperature Options\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eAmbient Heated\/Cooled (HC) -15 °C to +150 °C Ultra-High-Temperature (UHT) ambient to +210 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eAnalog Inputs\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e4 differential analog inputs with 24 bit resolution. Input range -10 V to +10 V\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eAnalog Outputs\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e2 analog outputs from user selectable measurements channels -10 V to +10 V\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eOther Inputs\/Outputs\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eAlarm in, Alarm out\/retransmit, Auto-Inject in, Auto inject contact closure retransmit, Recycle In\/Out (operates Orbit recycle valve)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eComputer Interface\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eEthernet\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eFront Panel Display\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e10.1\" (257 mm), capacitive high-resolution screen with multi-touch functionality, displays signals, graphs, instrument settings and diagnostics\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDimensions\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e58 cm (L) x 36 cm (W) x 26 cm (H)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.wyatt.com\/products\/dawn-brochure-request.html\" target=\"_blank\"\u003eBrochure\u003c\/a\u003e\u003c\/p\u003e","brand":"Wyatt Technology","offers":[{"title":"Ambient \/ Fused Silica, 658 nm \/ None","offer_id":46488396562511,"sku":"WD3-016500","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica, 658 nm \/ WyattQELS","offer_id":46488408555599,"sku":"WD3-016501","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica, 658 nm \/ DLS Fiber","offer_id":46488408588367,"sku":"WD3-0165DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica, 785 nm \/ None","offer_id":46488408621135,"sku":"WD3-017800","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica, 785 nm \/ WyattQELS","offer_id":46488408653903,"sku":"WD3-017801","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica, 785 nm \/ DLS Fiber","offer_id":46488408686671,"sku":"WD3-0178DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica, Aqueous, 658 nm \/ None","offer_id":46488408719439,"sku":"WD3-01AQ6500","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica, Aqueous, 658 nm \/ WyattQELS","offer_id":46488408752207,"sku":"WD3-01AQ6501","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica, Aqueous, 658 nm \/ DLS Fiber","offer_id":46488408784975,"sku":"WD3-01AQ65DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica + Wide-Bore, 658 nm \/ WyattQELS","offer_id":46488408817743,"sku":"WD3-01036501","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Fused Silica + Wide-Bore, 658 nm \/ DLS Fiber","offer_id":46488408850511,"sku":"WD3-010365DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Wide-Bore Fused Silica, 658 nm \/ WyattQELS","offer_id":46488408883279,"sku":"WD3-036501","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Wide-Bore Fused Silica, 658 nm \/ DLS Fiber","offer_id":46488408916047,"sku":"WD3-0365DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ 2 × Wide-Bore Fused Silica, 658 nm \/ WyattQELS","offer_id":46488408948815,"sku":"WD3-03036501","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ 2 × Wide-Bore Fused Silica, 658 nm \/ DLS Fiber","offer_id":46488408981583,"sku":"WD3-030365DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ To be specified \/ To be specified","offer_id":46488409014351,"sku":"WD3","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Heated\/Cooled \/ Fused Silica, 658 nm \/ None","offer_id":46488396595279,"sku":"WD3HC-016500","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Heated\/Cooled \/ Fused Silica, 658 nm \/ WyattQELS","offer_id":46488409047119,"sku":"WD3HC-016501","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Heated\/Cooled \/ Fused Silica, 658 nm \/ DLS Fiber","offer_id":46488409079887,"sku":"WD3HC-0165DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Heated\/Cooled \/ Fused Silica, Aqueous, 658 nm \/ None","offer_id":46488409112655,"sku":"WD3HC-01AQ6500","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Heated\/Cooled \/ Fused Silica, Aqueous, 658 nm \/ WyattQELS","offer_id":46488409145423,"sku":"WD3HC-01AQ6501","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Heated\/Cooled \/ Fused Silica, Aqueous, 658 nm \/ DLS Fiber","offer_id":46488409178191,"sku":"WD3HC-01AQ65DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Heated\/Cooled \/ To be specified \/ To be specified","offer_id":46488409210959,"sku":"WD3HC","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Temperature Regulated \/ Fused Silica, 658 nm \/ None","offer_id":46488396628047,"sku":"WD3TR-016500","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Temperature Regulated \/ Fused Silica, 658 nm \/ WyattQELS","offer_id":46488409243727,"sku":"WD3TR-016501","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Temperature Regulated \/ Fused Silica, 658 nm \/ DLS Fiber","offer_id":46488409276495,"sku":"WD3TR-0165DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Temperature Regulated \/ Fused Silica, Aqueous, 658 nm \/ None","offer_id":46488409309263,"sku":"WD3TR-01AQ6500","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Temperature Regulated \/ Fused Silica, Aqueous, 658 nm \/ WyattQELS","offer_id":46488409342031,"sku":"WD3TR-01AQ6501","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Temperature Regulated \/ Fused Silica, Aqueous, 658 nm \/ DLS Fiber","offer_id":46488409374799,"sku":"WD3TR-01AQ65DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Temperature Regulated \/ To be specified \/ To be specified","offer_id":46488409407567,"sku":"WD3TR","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ultra-High Temperature \/ Fused Silica, 658 nm \/ None","offer_id":46488396660815,"sku":"WD3UH-016500","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ultra-High Temperature \/ To be specified \/ To be specified","offer_id":46488409440335,"sku":"WD3UH","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/DAWN-Hero-Neon-9-19_ec09b7e7-d1cb-4312-92a5-e60c5d7ceefb.jpg?v=1787675350"},{"product_id":"wyatt-minidawn-multi-angle-light-scattering-detector","title":"miniDAWN Multi-Angle Light Scattering Detector","description":"\u003cspan\u003e\u003cp align=\"center\"\u003e\u003cimg alt=\"DAWN\" fetchpriority=\"high\" src=\"https:\/\/www.wyatt.com\/wp-content\/uploads\/2019\/10\/miniDAWN-Hero-Neon-9-24-19.jpg\" width=\"65%\"\u003e\u003c\/p\u003e\u003c\/span\u003e\n\u003cp\u003eThe Best in Basic Multi-Angle Light Scattering for Absolute Macromolecular Analysis.\u003c\/p\u003e\n\u003cp\u003eMolar Mass\u003c\/p\u003e\n\u003cp\u003eThe miniDAWN determines absolute molar mass and size to characterize proteins, peptides, small polymers and nanoparticles in solution. Coupled to size exclusion chromatography (SEC or GPC), it eliminates the uncertainty and hassle of column calibration, for true confidence in macromolecular characterization.\u003c\/p\u003e\n\u003chr class=\"no_line\" style=\"margin: 0 auto 10px auto\"\u003e\n\u003cp\u003eSuperb Sensitivity\u003c\/p\u003e\n\u003cp\u003eThe miniDAWN not only offers superb sensitivity—it further enhances productivity thanks to greatly enhanced field serviceability and easy data analysis with One-Click Mw\u003csup\u003e™\u003c\/sup\u003e. \u003c\/p\u003e\n\u003chr class=\"no_line\" style=\"margin: 0 auto 10px auto\"\u003e\n\u003cp\u003eCompatible with ASTRA\u003csup\u003e™\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003eThe miniDAWN is accompanied by \u003ca href=\"https:\/\/www.wyatt.com\/products\/software\/astra.html\"\u003eASTRA\u003c\/a\u003e, the most versatile software package available for analysis of online multi-angle and dynamic light scattering. ASTRA and the miniDAWN incorporate advanced ease-of-use features that help guarantee excellent measurements with a single click.\u003c\/p\u003e\n\u003cp\u003eMolar mass, absolutely\u003c\/p\u003e\n\u003cdiv class=\"column one-second\"\u003e\n\u003cp\u003eWyatt's miniDAWN is most often used in conjunction with size exclusion chromatography \n  \t\t(\u003ca href=\"https:\/\/www.wyatt.com\/solutions\/techniques\/sec-mals-molar-mass-size-multi-angle-light-scattering.html\"\u003eSEC-MALS\u003c\/a\u003e) or field-flow fractionation \n  \t\t(\u003ca href=\"https:\/\/www.wyatt.com\/solutions\/techniques\/fff-mals-characterization-of-nanoparticles-colloids-macromolecules.html\"\u003eFFF-MALS\u003c\/a\u003e) \n  \t\tto determine distributions of molecular weight, size and composition. No need to make assumptions about molecular \n          conformation or ideal column interactions.\u003c\/p\u003e\n\u003cp\u003eCharacterize:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eProteins, small peptides and oligonucleotides\u003c\/li\u003e\n\u003cli\u003eSynthetic and natural polymers\u003c\/li\u003e\n\u003cli\u003eNanoparticles, virus-like  particles and vesicles\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eMeasurement Range:\u003c\/p\u003e\n\u003cul style=\"margin-right: 15 px;\"\u003e\n\u003cli\u003eMW from  200 Da to 10 MDa\u003c\/li\u003e\n\u003cli\u003e\n\u003ci\u003er\u003csub\u003eg\u003c\/sub\u003e\u003c\/i\u003e from  10 to 50 nm, up to 150 nm with shape-specific models\u003c\/li\u003e\n\u003cli\u003esensitivity down to 25 ng of 100 kDa polystyrene in THF, injected on a standard GPC column\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"column one-second\"\u003e\n\u003cimg alt=\"protein molar mass characterization \n        with miniDAWN\" src=\"https:\/\/www.wyatt.com\/wp-content\/uploads\/2019\/05\/4-protein_Mwchromatogram_50pc.jpg\" style=\"float: none; width:90%; margin-left: 15px;\" title=\"protein molar mass characterization with miniDAWN\"\u003e\n\u003cp style=\"color: #075c97;\"\u003eThe miniDAWN determines molecular weight independently of column calibration. Here MALS \n      shows that the earliest-eluting molecule does not have the highest molar mass.  \n    \t\u003c\/p\u003e\n\u003c\/div\u003e\n\n\u003cp\u003e\n          The miniDAWN's performance is exceeded only by the \n          \u003ca href=\"https:\/\/www.wyatt.com\/products\/instruments\/dawn-multi-angle-light-scattering-detector.html\"\u003eDAWN\u003csup\u003e™\u003c\/sup\u003e\u003c\/a\u003e which covers a wider range \n          of size and molecular weight, with even better sensitivity and additional optional modules.\n      \u003c\/p\u003e\n\u003cp\u003eUltrasonic Cleaning Included\u003c\/p\u003e\n\u003cp\u003eEach miniDAWN includes an embedded \u003ca href=\"https:\/\/store.wyatt.com\/shop\/minidawn-treos\/treos-ii\/wyatt-comet\/\"\u003e\u003cb\u003eCOMET\u003csup\u003e™\u003c\/sup\u003e\u003c\/b\u003e\u003c\/a\u003e ultrasonic transducer that cleans the flow cell automatically by agitating the fluid and loosening particles from the glass surfaces.\u003c\/p\u003e\n\u003cp\u003eModularity = Productivity\u003c\/p\u003e\n\u003cp\u003eThe miniDAWN incorporates a fully modular design. Each module can be tested independently by the software to verify that it is functioning correctly. This imparts nearly complete field serviceability, since malfunctioning modules can be replaced and validated on-site by service engineers with no further calibration or alignment.\u003c\/p\u003e\n\u003cp\u003eThe miniDAWN is also field-upgradeable: the embedded \u003ca href=\"https:\/\/store.wyatt.com\/shop\/udawn\/udawn3\/wiq\/\"\u003eWyattQELS\u003csup\u003e™\u003c\/sup\u003e DLS Module\u003c\/a\u003e for measuring hydrodynamic radii from 0.5 to 50 nm can be installed on-site as well as in new units shipped from the factory.\u003c\/p\u003e\n\u003cp\u003eNot just SEC-MALS...\u003c\/p\u003e\n\u003cp\u003eWyatt's miniDAWN may be used in batch (off-line) mode or in conjunction with a \n          \u003ca href=\"https:\/\/www.wyatt.com\/products\/instruments\/calypso-ii-label-free-biomolecular-interactions.html\"\u003eCalypso\u003csup\u003e™\u003c\/sup\u003e\u003c\/a\u003e CG-MALS system for \n          characterization of average solution properties as well as macromolecular interaction properties including protein-protein \n          binding affinity and complex stoichiometry.\u003c\/p\u003e\n\u003cdiv class=\"column one-second\"\u003e\n\u003cp\u003eSimplicity personified\u003c\/p\u003e\n\u003cp\u003eWith miniDAWN and ASTRA\u003csup\u003e™\u003c\/sup\u003e, SEC-MALS became a whole lot easier. Sample-specific methods are set up in three short steps with \n          ASTRA's Method Wizard, and new capabilities for automatic data processing mean that it takes just one click from your sample to a \n          full report of the molecular weight and size results. \u003c\/p\u003e\n\u003cp\u003eThe miniDAWN's System Ready monitor will even let you know when the system is fully equilibrated with low baseline noise,\n          ready to run.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"column one-second\"\u003e\n\u003cimg alt=\"Astra\" src=\"https:\/\/www.wyatt.com\/wp-content\/uploads\/2019\/05\/astra-steps.jpg\" style=\"float:none; width:90%;\" title=\"Astra\"\u003e\n\u003c\/div\u003e\n\u003ch2\u003eSpecifications\u003c\/h2\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMolar Mass Range\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e200 Da to 10 MDa (proteins) or 1 MDa (linear polymers)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMolecular Size Range ( R g )\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e≈ 10 nm to 50 nm, up to 150 nm with shape-specific models\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMolecular Size Range ( R h )\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eIn flow mode, 0.5 nm to 50 nm ; batch mode 0.5 nm to 1 μm (requires WyattQELS DLS module or DynaPro NanoStar + fiber optic connection)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSensitivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e25 ng of 100 kDa polystyrene in THF or 500 ng of BSA in PBS, assuming standard 7.8 mm x 300 mm SEC column and no post-column filter\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMobile Phase Compatibility\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eAll-solvent compatible (aqueous and organic); Wetted materials are 316 stainless steel, fused silica, and Kalrez\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMALS Detectors\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eHigh-gain, high dynamic range photodiodes at 3 detection angles\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eAuxiliary Detectors\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eLaser monitor for stabilization feedback; forward transmission monitor to correct signals for absorbing samples and to assess data quality\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDynamic Range\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e3,300,000:1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDLS Detector (optional)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eWyattQELS dynamic light scattering module installs directly inside the miniDAWN chassis. Alternatively, the optical fiber pickup of the DynaPro NanoStar cuvette-based DLS instrument or Mobius DLS-ELS instrument may be installed in the miniDAWN.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eLaser Wavelength\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e658 nm ± 4 nm\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eLaser Power Control\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eProgrammable 10% to 100%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSample Temperature Control\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eAmbient\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eAnalog Inputs\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e2 differential analog inputs with 24 bit resolution; Input range -10 V to +10 V\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eAnalog Outputs\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e1 analog output from user selectable measurements channels -10 V to +10 V\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eOther Inputs\/Outputs\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eAlarm in, Alarm out\/retransmit, Auto-inject in, Auto inject contact closure retransmit, Recycle In\/Out (operates Orbit recycle valve)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eComputer Interface\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eEthernet\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eProcessed Data Rate\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eUp to 36.6 Hz\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eFront Panel Display\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e7\" (178 mm), high-resolution, multi-touch display for viewing\/setting signals, instrument settings and diagnostics\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDimensions\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e58 cm (L) x 36 cm (W) x 18 cm (H)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.wyatt.com\/products\/minidawn-brochure-request.html\" target=\"_blank\"\u003eBrochure\u003c\/a\u003e\u003c\/p\u003e","brand":"Wyatt Technology","offers":[{"title":"Standard \/ No QELS","offer_id":46488396922959,"sku":"WMD3-00","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Standard \/ With QELS","offer_id":46488409473103,"sku":"WMD3-01","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Standard \/ With DLS","offer_id":46488409505871,"sku":"WMD3-DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Aqueous \/ No QELS","offer_id":46488409538639,"sku":"WMD3-AQ00","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Aqueous \/ With QELS","offer_id":46488409571407,"sku":"WMD3-AQ01","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Aqueous \/ With DLS","offer_id":46488409604175,"sku":"WMD3-AQDLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"To be specified \/ To be specified","offer_id":46488409636943,"sku":"WMD3","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/miniDAWN-Hero-Neon-9-24-19.jpg?v=1787675355"},{"product_id":"wyatt-microdawn-mals-detector-for-uhplc","title":"microDAWN MALS Detector for UHPLC","description":"\u003cspan\u003e\u003cp align=\"center\"\u003e\u003cimg alt=\"microDAWN\" src=\"https:\/\/www.wyatt.com\/wp-content\/uploads\/2019\/10\/microDAWN-Hero-Neon-9-24-19.jpg\" width=\"65%\"\u003e\u003c\/p\u003e\u003c\/span\u003e\n\u003cp\u003eThe Only Multi-Angle Light Scattering Detector for UHPLC\u003c\/p\u003e\n\u003cp\u003eUHPLC-SEC System\u003c\/p\u003e\u003cp\u003eThe microDAWN can be coupled to \u003ci\u003eany\u003c\/i\u003e UHPLC-SEC system to determine absolute molecular weights and sizes of polymers, peptides, or proteins directly, without resorting to column calibration or reference standards. The microDAWN produces minimal band broadening in order to maintain the narrow peaks typical of UHPLC, while meeting or exceeding the sensitivity of the miniDAWN\u003csup\u003e™\u003c\/sup\u003e.\u003c\/p\u003e\n\u003chr class=\"no_line\" style=\"margin: 0 auto 10px auto\"\u003e\n\u003cp\u003ePolymer Characterization\u003c\/p\u003e\n\u003cp style=\"display: flex; align-items: flex-start; gap: 10px;\"\u003e\n\u003ci class=\"fa fa-file-pdf-o fa-lg\" style=\"flex-shrink: 0; margin-top: 4px;\"\u003e\u003c\/i\u003e\n\u003cspan\u003e\n    \n      Read our paper published in Nature Scientific Reports:\n    \u003cbr\u003e\n\u003ca href=\"https:\/\/www.nature.com\/articles\/s41598-017-09051-1\" style=\"\" target=\"_blank\"\u003e“Measuring proteins with greater speed and resolution while reducing sample size”\u003c\/a\u003e\n\u003c\/span\u003e\n\u003c\/p\u003e\n\u003chr class=\"no_line\" style=\"margin: 0 auto 10px auto\"\u003e\n\u003cp\u003eUse of SEC-MALS\u003c\/p\u003e\n\u003cp style=\"display: flex; align-items: flex-start; gap: 10px;\"\u003e\n\u003ci class=\"fa fa-file-pdf-o fa-lg\" style=\"flex-shrink: 0; margin-top: 4px;\"\u003e\u003c\/i\u003e\n\u003cspan\u003e\n    \n      Download our white paper on the microDAWN:\n    \u003cbr\u003e\n\u003ca href=\"https:\/\/wyattfiles.s3-us-west-2.amazonaws.com\/literature\/white-papers\/WP1004-Absolute-characterization-of-polymers-with-light-scattering-and-UHP-SEC.pdf\" style=\"\" target=\"_blank\"\u003e“Absolute characterization of polymers with light scattering and UHP-SEC”\u003c\/a\u003e\n\u003c\/span\u003e\n\u003c\/p\u003e\n\u003cdiv class=\"column one-second\"\u003e\n\u003cp\u003eThe microDAWN MALS detector performs absolute characterization of macromolecules eluting from UHPLC, determining molar mass and size \u003ci\u003eindependently\u003c\/i\u003e of retention time and molecular reference standards. This instrument offers superb sensitivity over a wide range of molar mass, size and concentrations. In most respects the microDAWN is similar to the well-established \n      \t\u003ca href=\"https:\/\/www.wyatt.com\/products\/instruments\/minidawn-multi-angle-light-scattering-detector-sec-mals.html\"\u003eminiDAWN™\u003c\/a\u003e, a workhorse MALS instrument used in hundreds of labs around the world for characterizing proteins \n     \t and other molecules smaller than 50 nm in radius.\u003c\/p\u003e\n\u003cp\u003eDistinctly from the miniDAWN, the microDAWN is uniquely suitable for use in conjunction with UHPLC Size Exclusion \n      \tChromatography (\u003ca href=\"https:\/\/www.wyatt.com\/solutions\/techniques\/sec-mals-molar-mass-size-multi-angle-light-scattering.html\"\u003eSEC-MALS\u003c\/a\u003e) thanks to its small interdetector dispersion. In some cases it may be used with ion-exchange or other types of chromatography. Regardless of the specifics, the microDAWN produces minimal band broadening in order to maintain the narrow peaks typical of UHPLC.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"column one-second\" style=\"text-align:center;\"\u003e\n\u003cdiv style=\"padding: 15px;\"\u003e\n\u003cimg align=\"right\" alt=\"microDAWN UHPLC Experimental Setup\" height:=\"399px\" src=\"https:\/\/www.wyatt.com\/wp-content\/uploads\/2019\/05\/UHPLC-microDAWN-microOptilab-Neon-System.jpg\" width=\"350px\"\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cp\u003e\n\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003ci\u003eM\u003c\/i\u003e\u003csub\u003ew\u003c\/sub\u003e from 200 Da to 10 MDa\u003c\/li\u003e\n\u003cli\u003eSensitivity: 1.0 µg\/mL BSA (66.4 kDa) in PBS; 50 ng\/mL 100 kDa polystyrene in THF.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ci\u003eR\u003c\/i\u003e\u003csub\u003eg\u003c\/sub\u003e from 10 to 50 nm\u003c\/li\u003e\n\u003cli\u003eUltra-stable laser\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThe microDAWN and its companion \n          \u003ca href=\"https:\/\/www.wyatt.com\/products\/instruments\/microOptilab-uhplc-refractometer-sec-mals.html\"\u003emicroOptilab\u003csup\u003e™\u003c\/sup\u003eRefractive Index Detector\u003c\/a\u003e interface to most standard UHPLC systems. As these detectors are based on the advanced technology of Wyatt's miniDAWN and \u003ca href=\"https:\/\/www.wyatt.com\/products\/instruments\/optilab-refractive-index-detector.html\"\u003eOptilab\u003csup\u003e™\u003c\/sup\u003e\u003c\/a\u003e, respectively, users may be confident in the underlying capabilities cited in \u003ca href=\"https:\/\/www.wyatt.com\/library\/bibliography.html\"\u003ethousands of \n            peer-reviewed publications\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eUltrasonic Cleaning Included\u003c\/p\u003e\n\u003cp\u003eEach microDAWN includes a \u003ca href=\"https:\/\/store.wyatt.com\/shop\/minidawn-treos\/treos-ii\/wyatt-comet\/\"\u003e\u003cb\u003eCOMET\u003csup\u003e™\u003c\/sup\u003e\u003c\/b\u003e\u003c\/a\u003e ultrasonic transducer that cleans MALS flow cells automatically by agitating the fluid and loosening particles from the glass surfaces.\u003c\/p\u003e\n\n\u003ch2\u003eSpecifications\u003c\/h2\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMolar Mass Range\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e200 Da to 10 MDa (proteins) or 1 MDa (linear polymers)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMolecular or Particle Size Range (Radius, R g )\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e10 nm to 50 nm, up to 150 nm with shape-specific models\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMolecular Size Range ( R h )\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eIn flow mode, 0.5 nm to 30 nm; batch mode 0.5 nm to 1 μm (requires WyattQELS DLS module or DynaPro NanoStar + fiber optic connection)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSensitivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e3.5 ng of 100 kDa polystyrene in THF or 70 ng of BSA in PBS, assuming a 15 cm UHPLC-SEC column and no post-column filter\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMALS Detectors\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eHigh-gain, high dynamic range photodiodes at 3 detection angles\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDynamic Range\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e3,300,000:1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eAuxiliary Detectors\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eLaser monitor for stabilization feedback; forward transmission monitor to correct signals for absorbing samples and to assess data quality\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDLS Detector (optional)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eWyattQELS dynamic light scattering module installs directly inside the microDAWN chassis. Alternatively, the optical fiber pickup of the DynaPro NanoStar cuvette-based DLS instrument or ZetaStar DLS-ELS instrument may be installed in the DAWN .\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eLaser Wavelength\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e658 nm ± 4 nm\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eLaser Power Control\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eProgrammable 10% to 100%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSample Temperature Control\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eAmbient\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eInterdetector Band Broadening\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e(Increase in FWHM @ 0.3 mL\/min) Upstream detector to microDAWN: \u0026lt; 1.5 μL;\nUpstream detector to downstream detector: \u0026lt; 1.6 μL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eWetted Materials\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e316 stainless steel, fused silica, PEEK, PTFE, MP35N iron-free alloy\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eAnalog Inputs\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e2 differential analog inputs with 24 bit resolution; Input range -10 V to +10 V\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eAnalog Outputs\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e1 analog output from user selectable measurements channels -10 V to +10 V\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eOther Inputs\/Outputs\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eAlarm in, Alarm out\/retransmit, Auto-inject in, Auto inject contact\nclosure retransmit, Recycle In\/Out (operates Orbit recycle valve)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eComputer Interface\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eEthernet\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eFront Panel Display\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e7\" (178 mm), high-resolution, multi-touch display for viewing\/setting signals, instrument settings and diagnostics\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eProcessed Data Transmission Rate\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eUp to 73 Hz\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDimensions\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e58 cm (L) x 36 cm (W) x 18 cm (H)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.wyatt.com\/products\/microdawn-brochure-request.html\" target=\"_blank\"\u003eBrochure\u003c\/a\u003e\u003c\/p\u003e","brand":"Wyatt Technology","offers":[{"title":"Standard \/ No QELS","offer_id":46488397185103,"sku":"WUD3-00","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Standard \/ With QELS","offer_id":46488409768015,"sku":"WUD3-01","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Standard \/ With DLS","offer_id":46488409800783,"sku":"WUD3-DLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Aqueous \/ No QELS","offer_id":46488409833551,"sku":"WUD3-AQ00","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Aqueous \/ With QELS","offer_id":46488409866319,"sku":"WUD3-AQ01","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Aqueous \/ With DLS","offer_id":46488409899087,"sku":"WUD3-AQDLS","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"To be specified \/ To be specified","offer_id":46488409931855,"sku":"WUD3","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/microDAWN-Hero-Neon-9-24-19_0af21c4e-49d5-427d-84b4-03e944a0c11a.jpg?v=1787675358"},{"product_id":"wyatt-ultradawn-real-time-mals-detector","title":"ultraDAWN Real-Time MALS Detector","description":"\u003cspan\u003e\u003cp align=\"center\"\u003e\u003cimg src=\"https:\/\/www.wyatt.com\/wp-content\/uploads\/2026\/07\/wyatt-ultradawn-ultradawn-pilot.webp\" width=\"85%\"\u003e\u003c\/p\u003e\u003c\/span\u003e\n\u003cp\u003eA breakthrough in process analytical technology for production of nanoparticles, biopharmaceuticals and polymers.\u003c\/p\u003e\n\u003cp\u003eReal-Time Multi-Angle Light Scattering\u003c\/p\u003e\n\u003cp\u003eultraDAWN measures multi-angle and dynamic light scattering and reports the results – molecular weight, size, polydispersity, particle concentration and more – in real time. With \u003ca href=\"https:\/\/www.wyatt.com\/solutions\/techniques\/real-time-mals.html\"\u003eRT-MALS\u003c\/a\u003e, critical quality attributes (CQAs) can be monitored directly, for rapid feedback on product and process quality. \u003c\/p\u003e\n\u003chr class=\"no_line\" style=\"margin: 0 auto 10px auto\"\u003e\n\u003cp\u003eBenefits of RT-MALS\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eAccelerate process development and scale-up\u003c\/li\u003e\n\u003cli\u003eIncrease yield, reduce overall time until lot release\u003c\/li\u003e\n\u003cli\u003eMaintain product quality with confidence\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eWhere MALS and PAT meet\u003c\/p\u003e\n\u003cp\u003eThe ultraDAWN and ultraDAWN Pilot are unique members of the DAWN\u003csup\u003e™\u003c\/sup\u003e family of MALS instruments. Instead of residing in the analytical lab, they are adapted to inline\/online integration with bioprocess development  and production environments. Together with OBSERVER\u003csup\u003e™\u003c\/sup\u003e real-time software, ultraDAWN calculates and reports molar mass, size, particle concentration and other attributes, up to 300 times per minute, during a unit operation such as chromatographic purification or lipid nanoparticle production.\u003c\/p\u003e\n\u003cp\u003ePAT instrumentation typically monitors process parameters such as pH, temperature, pressure, UV and feedstock, which are tied only indirectly to product properties and quality. ultraDAWN revolutionizes process development with its continuous, direct measurements of relevant product attributes.\u003c\/p\u003e\n\u003cdiv class=\"column one-second\"\u003e\n\u003cp\u003eBuilt in the NEON\u003csup\u003e™\u003c\/sup\u003e platform, ultraDAWN provides an intelligent user interface indicating real-time and time sequences of molar mass, size and\/or particle concentration as well as system health diagnostics and event history. With photodetectors at eighteen scattering angles plus one more to measure light transmitted through the flow cell, the ultraDAWN provides a solution for monitoring multiple biophysical product attributes:\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eMacromolecules: \u003c\/b\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ci\u003eM\u003c\/i\u003e\u003csub\u003ew\u003c\/sub\u003e from 10\u003csup\u003e3\u003c\/sup\u003e to 10\u003csup\u003e9\u003c\/sup\u003e g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003ci\u003eR\u003c\/i\u003e\u003csub\u003eg\u003c\/sub\u003e from 10 to 250 nm\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cb\u003eNanoparticles:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eradius from 10 to 250 nm\u003c\/li\u003e\n\u003cli\u003eparticle concentration (concentration range depends on particle size)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cb\u003eAAV and other small viral vectors:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003efull:total capsid ratio Vg\/Cp\u003c\/li\u003e\n\u003cli\u003etotal, full and empty capsid titer (AAV\/mL)\u003c\/li\u003e\n\u003cli\u003etotal AAV, capsid and genome molecular weight\u003c\/li\u003e\n\u003cli\u003erms radius \u003ci\u003eR\u003c\/i\u003e\u003csub\u003eg\u003c\/sub\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eWith the addition of an optional WyattQELS embedded DLS module, ultraDAWN also  monitors hydrodynamic radius from 0.5 to 1000 nm (flow-rate dependent) and the polydispersity index.\u003c\/p\u003e\n\u003cp\u003eultraDAWN offers versatile options for PAT, including:\u003c\/p\u003e\n\u003cul\u003e\n\u003cp\u003eIn-line or on-line configuration\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eultraDAWN:\u003c\/b\u003eIn-line flow up to 150 mL\/min, and up to 2 L\/min with a flow splitter\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eultraDAWN Pilot:\u003c\/b\u003e In-line flow up to 1000 mL\/min, and up to 15 L\/min with a flow splitter\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eProcess sampling or slipstream sampling with recirculation\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eultraDAWN:\u003c\/b\u003e 0.5 to 50 mL\/min\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eultraDAWN Pilot:\u003c\/b\u003e 50–500 mL\/min\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cli\u003eAnalog integration with bench-scale preparative chromatography and other processing equipment\u003c\/li\u003e\n\u003cli\u003eDigital integration with production control software via OPC-UA\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"column one-second\"\u003e\n\u003cp align=\"center\"\u003e\u003cimg align=\"center\" alt=\"ultraDAWN\" src=\"https:\/\/www.wyatt.com\/wp-content\/uploads\/2019\/11\/ultraDAWN-UI.jpg\" title=\"ultraDAWN\" width=\"350px\"\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch2\u003eSpecifications\u003c\/h2\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMolar Mass Range\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e1 kDa to 1 GDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSize Range ( R g )\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e10 nm to 250 nm\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSize Range ( R h )\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eIn flow mode, 0.5 nm to 300 nm ; batch mode 0.5 nm to 1 μm \n(requires WyattQELS™ DLS module).\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eData Acquisition Rate\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eup to 300 measurements per minute\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eAccuracy\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e5%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eRepeatability\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e2%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eTemperature Options\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eultraDAWN: Ambient or heated\/cooled (HC) -15 °C to +150 °C ultraDAWN Pilot: ambient only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSolvent Compatibility\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eAll-solvent compatible (aqueous and organic). Wetted materials are 316 stainless steel, fused silica and Kalrez.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMaximum Inline Flow Rate\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eultraDAWN: 150 mL\/min @  1 cP ultraDAWN Pilot: 1000 mL\/min @ 1 cP\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMaximum Viscosity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e30 cP (when using HPLC pump with standard or heated\/cooled ultraDAWN in on-line configuration)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMALS Detectors\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eHigh-gain, high dynamic range photodiodes at 18 detection angles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eAnalog Inputs\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e4 analog input lines for external signals from -10V to +10V\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eAnalog Outputs\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e4 analog output lines for sending trigger signals to process equipment\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eOther Inputs\/Outputs\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eAlarm In, Alarm Out\/Retransmit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eComputer Interface\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eEthernet\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eFront Panel Display\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e10.1\" (257 mm), capacitive high-resolution screen with multi-touch functionality, displays signals, graphs, instrument settings and diagnostics. May be used with gloves.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDimensions\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e58 cm (L) x 36 cm (W) x 26 cm (H)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.wyatt.com\/products\/ultradawn-brochure-request.html\" target=\"_blank\"\u003eBrochure\u003c\/a\u003e\u003c\/p\u003e","brand":"Wyatt Technology","offers":[{"title":"Ambient \/ No Attenuators \/ No QELS","offer_id":46488409964623,"sku":"WULD1-010000","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ No Attenuators \/ With QELS","offer_id":46488409997391,"sku":"WULD1-010001","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Even Attenuators \/ No QELS","offer_id":46488410030159,"sku":"WULD1-010100","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ Even Attenuators \/ With QELS","offer_id":46488410062927,"sku":"WULD1-010101","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ All Attenuators \/ No QELS","offer_id":46488410095695,"sku":"WULD1-010200","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ All Attenuators \/ With QELS","offer_id":46488410128463,"sku":"WULD1-010201","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Ambient \/ To be specified \/ To be specified","offer_id":46488410161231,"sku":"WULD1","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Heated\/Cooled \/ No Attenuators \/ No QELS","offer_id":46488397283407,"sku":"WULD1T-010000","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Heated\/Cooled \/ Even Attenuators \/ No QELS","offer_id":46488410193999,"sku":"WULD1T-010100","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Heated\/Cooled \/ All Attenuators \/ No QELS","offer_id":46488410226767,"sku":"WULD1T-010200","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"Heated\/Cooled \/ To be specified \/ To be specified","offer_id":46488410259535,"sku":"WULD1T","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/wyatt-ultradawn-ultradawn-pilot.webp?v=1787675360"},{"product_id":"wyatt-wyattqels-dynamic-light-scattering-module","title":"WyattQELS Dynamic Light Scattering Module","description":"\u003cp\u003eIntegrates inside a MALS to provide simultaneous DLS measurements of hydrodynamic radius (Rh) in the same scattering volume viewed by the MALS detectors; integration eliminates artifacts due to band broadening or temporal displacement between separate detectors.\nRequest More Information\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.wyatt.com\/products\/dawn-brochure-request.html\" target=\"_blank\"\u003eBrochure\u003c\/a\u003e\u003c\/p\u003e","brand":"Wyatt Technology","offers":[{"title":"Default Title","offer_id":46488397643855,"sku":"WIQ","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/WIQ-A.jpg?v=1787675362"},{"product_id":"wyatt-eclipse-field-flow-fractionation-system","title":"Eclipse Field-Flow Fractionation System","description":"\u003cspan\u003e\u003cp align=\"center\"\u003e\u003cimg alt=\"Eclipse DualTec\" class=\"scale-with-grid\" fetchpriority=\"high\" src=\"https:\/\/www.wyatt.com\/wp-content\/uploads\/2020\/10\/Eclipse-Hero.jpg\" width=\"700\"\u003e\u003c\/p\u003e\u003c\/span\u003e\n\u003cp\u003eThe ultimate separation system for nanoparticles and macromolecules\u003c\/p\u003e\n\u003cp\u003eUniquely Versatile\u003c\/p\u003e\n\u003cp\u003eField-flow fractionation is a uniquely versatile means of size-based separations, capable of fractionating viral particles, liposomes and lipid nanoparticles, emulsions, proteins and aggregates, polysaccharides and technical polymers, engineered nanoparticles, colloidal soil suspensions, chemical mechanical polishing slurries, and many more - with no stationary phase and almost no shear. Separation of biotherapeutics can usually be done in full formulation buffer.\u003c\/p\u003e\n\u003cp\u003eThe Eclipse system is the foundation of FFF-MALS, a powerful technique for separation and comprehensive characterization of macromolecules and nanoparticles from 1 to 1000 nm in size. Eclipse brings FFF to a completely new level, combining exquisite performance and ease of use. Advanced features include the Dilution Control Module (DCM) and the ability to switch seamlessly between FFF and size-exclusion chromatography (SEC) separations. The Mobility add-on system expands Eclipse’s capabilities to include measurements of charge and zeta potential.\u003c\/p\u003e\n\u003chr class=\"no_line\" style=\"margin: 0 auto 0px auto\"\u003e\n\n\u003cdiv class=\"column one-second\" style=\"padding-right:10px\"\u003e\n\u003cp style=\"color:#075c97;\"\u003eSimplicity and quality, with built-in intelligence\u003c\/p\u003e\n\u003cp\u003eThe Eclipse FFF system combines several modules that are integrated seamlessly in VISION\u003csup\u003e™\u003c\/sup\u003e software:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eThe Eclipse FFF flow instrument\u003c\/li\u003e\n\u003cli\u003eWaters\u003csup\u003e™\u003c\/sup\u003e\n Arc\u003csup\u003e™\u003c\/sup\u003e HPLC pump and autosampler\u003c\/li\u003e\n\u003cli\u003eIndustry standard pump and autosampler (legacy only)\u003c\/li\u003e\n\u003cli\u003eEclipse FFF channel\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThese modules may be added:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eIndustry standard fraction collector\u003c\/li\u003e\n\u003cli\u003eMobility EAF4 system\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"column one-second\" style=\"padding-right:10px\"\u003e\n\u003cdiv style=\"padding:0px 30px 0px 30px\"\u003e\n\u003cp align=\"center\" style=\"padding-top:80px\"\u003e \u003cimg alt=\"fff-mals\" src=\"https:\/\/www.wyatt.com\/wp-content\/uploads\/2024\/04\/WAT-Arc-HPLC-Optilab-DAWN-Eclipse-1000.jpg\" width=\"80%\"\u003e \u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr class=\"no_line\" style=\"margin: 0 auto 0px auto\"\u003e\n\u003cdiv class=\"column one-second mobile-one\"\u003e\u003cdiv class=\"mcb-column-inner\"\u003e\n\u003cp\u003eEclipse instrument\u003c\/p\u003e\n\u003cp\u003eThe Eclipse FFF instrument is the heart of the FFF system. It incorporates four highly precise and stable flow controllers that ensure robust and repeatable fractionation runs, without the associated pulsation and inherent complexity and low reliability of the multiple pumps found in other FFF systems. \u003c\/p\u003e\n\u003cp\u003eEclipse supports both tip injection and focus-zone injection, enabling use of a variety of FFF separation channels and even a size-exclusion chromatography column.\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eOptional features:\u003c\/i\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eFFF-SEC switching\u003c\/li\u003e\n\u003cli\u003eDilution Control Module (DCM)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e(see Options tab for more information)\u003c\/p\u003e\n\u003cp\u003eThe user interface is based on a 10” multi-touch display that lets users track progress of the method, know about events or conditions that need attention, and perform any necessary manual operations such as flushing the channel. Built-in intelligence provides health indicators and guided user assistance as well as self-diagnostics procedure.\u003c\/p\u003e\n\u003cp\u003eFront end\u003c\/p\u003e\n\u003cp\u003eThe front end for an Eclipse FFF system comprises a Waters and other industry-standard pumps and autosampler. These components are recognized by analytical laboratories as state-of-the-art for reliability and performance:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eLow pump ripple and pulsation\u003c\/li\u003e\n\u003cli\u003eNo wasted sample (no need to overfill the autosampler – 100 µL are loaded for a 100 µL injection)\u003c\/li\u003e\n\u003cli\u003eUsed in tens of thousands of laboratories around the world, including in the demanding bio\/pharmaceutical industry.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv class=\"column one-second mobile-one\"\u003e\u003cdiv class=\"mcb-column-inner\"\u003e\n\u003cdiv style=\"padding:0px 30px 0px 30px\"\u003e\n\u003cp align=\"center\" style=\"padding-top:30px\"\u003e \u003cimg alt=\"fff-mals\" src=\"https:\/\/www.wyatt.com\/wp-content\/uploads\/2020\/10\/Eclipse-Hero.jpg\" width=\"80%\"\u003e \u003c\/p\u003e\n\u003cp align=\"center\"\u003e \u003cimg alt=\"fff-mals\" src=\"https:\/\/www.wyatt.com\/wp-content\/uploads\/2020\/10\/side-view-eclipse.jpg\" width=\"90%\"\u003e \u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003chr class=\"no_line\" style=\"margin: 0 auto 0px auto\"\u003e\n\u003cdiv class=\"column one-second mobile-one\"\u003e\u003cdiv class=\"mcb-column-inner\"\u003e\n\u003cp\u003eEclipse FFF channels\u003c\/p\u003e\n\u003cp\u003eFractionation, which is what it’s all about, takes place in the open FFF channel which incorporates a semi-permeable (ultrafiltration) membrane supported by a frit. Eclipse channels offer several key advantages including extra-rigid construction, built-in temperature regulation and built-in dilution control ports. A variety of FFF channels are available to meet different needs – see the Channels tab to learn more.\u003c\/p\u003e\n\u003cp\u003eVISION™\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/www.wyatt.com\/products\/software\/vision.html\"\u003eVISION software\u003c\/a\u003e is the intelligent human interface to an FFF-MALS system built on Wyatt Technology’s Eclipse™ FFF and DAWN™ MALS instruments. It comprises two primary modules:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eVISION DESIGN™ for in silico method design and optimization\u003c\/li\u003e\n\u003cli\u003eVISION RUN™ for running FFF methods, with continuous system monitoring and self-diagnostics to ensure no wasted runs, lost sample or empty solvent bottle.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eVISION interfaces with ASTRA™ software to coordinate synchronization and real-time display of light scattering data within VISION. Both software packages have been developed under a formal quality system and are available in 21 CFR Part 11 compliant options that fulfill GMP and GLP requirements.\u003c\/p\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cdiv class=\"column one-second mobile-one\"\u003e\u003cdiv class=\"mcb-column-inner\"\u003e\n\u003cdiv style=\"padding:0px 30px 0px 30px\"\u003e\n\u003cp align=\"center\" style=\"padding-top:30px\"\u003e \u003cimg alt=\"fff-mals\" src=\"https:\/\/www.wyatt.com\/wp-content\/uploads\/2021\/12\/Long-Channel-Exploded-12-21.jpg\" width=\"80%\"\u003e \u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003ch2\u003eSpecifications\u003c\/h2\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eEclipse\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eCompatible with aqueous and organic solvents. Corrosion-resistant from pH 2 to 12. Wetted materials: 316 stainless steel, FFKM perfluoroelastomer, FR3 stainless steel, Vespel. Cross-flow regulation from 6.67 to 0.03 mL\/min.\nPrecision of detector flow rate: 0.1% (with DCM). Dedicated fraction collector output port for minimal peak broadening.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eCommunications\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eEthernet\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eInputs\/Outputs\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eAlarm Out, Aux In with 18-bit effective resolution\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSoftware\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eVISION software suite. Comprises VISION DESIGN module for in silico method development and optimization, and VISION RUN for running sequences and coordinating ASTRA data acquisition.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eFFF-MALS Solution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eBasic FFF-MALS system includes Eclipse instrument, one separation channel (matched to customer application), Waters and other industry-standard pump and autosampler, DAWN MALS instrument, VISION software suite and ASTRA light scattering analysis software.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDilution Control Module\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eFactory-installed option. Increases sample concentration at the detector by up to a factor of 10 (up to 5 with negligible loss of resolution), controlled by software.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSEC Switching Option\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eFactory-installed option. Allows for automated software-controlled switching between SEC mode and FFF mode.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMobility\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eAdd-on option. Includes Mobility Module with pH sensor and conductivity sensor with software supported calibration, and Mobility channel. Maximum operating voltage ± 30 V, maximum current 30 mA; constant current or constant voltage mode. Wetted materials: platinum, titanium, polyetherimide, alumina ceramic, PTFE, Viton, PEEK, polycarbonate.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDetectors and Modules\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003ePDA, UV\/Vis, FLD, fraction collector, etc.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDLS\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eWyattQELS™ embedded dynamic light scattering module\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSelection\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eShort, Long, Dispersion Inlet and Semi-Prep Channels available. Channel types are offered as fixed-height channel (without spacer) and variable-height channel (with spacer) options. All channels are compatible with aqueous and organic solvents and come with DCM port. Maximum pressure 30 bar.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eTemperature Regulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eAmbient to 50 °C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eWetted Materials\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e316 stainless steel, fused silica, FFKM perfluoroelastomer, alumina ceramic. Polycarbonate or Mylar according to the selected spacer for variable-height channels.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSpacers\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eSelection ranges from 250 μm to 1000 μm, depending on channel. FFKM perfluoroelastomer-coated polycarbonate for aqueous solvents, Mylar for organic solvents.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMembranes\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003ePre-cut polyethersulfone or regenerated cellulose with molecular-weight cutoff from 2 to 30 kDa. Templates available to cut other materials to size.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDimensions\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e58 cm (L) x 36 cm (W) x 26 cm (H) (Eclipse instrument)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.wyatt.com\/products\/eclipse-brochure-request.html\" target=\"_blank\"\u003eBrochure\u003c\/a\u003e\u003c\/p\u003e","brand":"Wyatt Technology","offers":[{"title":"Standard","offer_id":46488398364751,"sku":"WEC","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"with Dilution Control Module","offer_id":46488398397519,"sku":"WECD","price":0.0,"currency_code":"ILS","in_stock":true},{"title":"with Dilution Module \u0026 HP Switch","offer_id":46488398430287,"sku":"WECDSH","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/Eclipse-Hero.jpg?v=1787675377"},{"product_id":"wyatt-calypso-ii-composition-gradient-system","title":"Calypso II Composition-Gradient System","description":"\u003cspan\u003e\u003cp align=\"center\"\u003e\u003cimg alt=\"Calypso II\" class=\"scale-with-grid\" src=\"https:\/\/www.wyatt.com\/wp-content\/uploads\/2019\/05\/Calypso.jpg\" title=\"Calypso\" width=\"65%\"\u003e\u003c\/p\u003e\u003c\/span\u003e\n\u003cp\u003eLabel-free, immobilization-free characterization of protein-protein and other macromolecular interactions with composition-gradient multi-angle light scattering.\u003c\/p\u003e\n\u003cp\u003eCG-MALS\u003c\/p\u003e\n\u003cp\u003eThe Calypso II, in conjunction with a \u003ca href=\"https:\/\/www.wyatt.com\/products\/instruments\/dawn-multi-angle-light-scattering-detector.html\"\u003eDAWN\u003csup\u003e™\u003c\/sup\u003e\u003c\/a\u003e or \u003ca href=\"https:\/\/www.wyatt.com\/products\/instruments\/minidawn-multi-angle-light-scattering-detector-sec-mals.html\"\u003eminiDAWN\u003csup\u003e™\u003c\/sup\u003e\u003c\/a\u003e MALS detector, measures binding affinities and absolute, molecular stoichiometries of complex biomolecular interactions.\u003c\/p\u003e\n\u003chr class=\"no_line\" style=\"margin: 0 auto 10px auto\"\u003e\n\u003cp\u003eWeight-Average Molar Mass\u003c\/p\u003e\n\u003cp\u003eIn addition to equilibrium association constants \u003ci\u003eK\u003c\/i\u003e\u003csub\u003ed\u003c\/sub\u003e and absolute stoichiometry of reversible self- and hetero-associations, it can also help determine reaction or aggregation rates, non-specific interaction parameters (virial coefficients) and even automate measurements of weight-average molar mass and \u003ci\u003edn\/dc \u003c\/i\u003efor polymers.\u003c\/p\u003e\n\u003chr class=\"no_line\" style=\"margin: 0 auto 10px auto\"\u003e\n\u003cp\u003eCALYPSO\u003csup\u003e™\u003c\/sup\u003e Software\u003c\/p\u003e\n\u003cp\u003eIncluded with each Calypso is a copy of \u003ca href=\"https:\/\/www.wyatt.com\/products\/software\/calypso-software.html\"\u003eCALYPSO software\u003c\/a\u003e, the most versatile software package available for analysis of biomolecular interactions in solution by light scattering.\u003c\/p\u003e\n\u003cdiv class=\"column one-second\"\u003e\n\u003cp\u003eCreating composition gradients...\u003c\/p\u003e\n\u003cp\u003eCG-MALS employs a Calypso connected to a MALS instrument and optional concentration detector. The Calypso performs sample preparation and delivery, combining up to three different solution in precise mixing ratios and injecting into the detectors.\u003c\/p\u003e\n\u003cp\u003eAccurate compositions result from setting the Calypso's pumps to appropriate flow rate ratios, all controlled from the CALYPSO\u003csup\u003e™\u003c\/sup\u003e software through an intuitive GUI. Mixing is achieved by dispensing the solutions simultaneously from all three pumps via a static mixer.\u003c\/p\u003e\n\u003cp\u003e...that work with MALS detectors\u003c\/p\u003e\n\u003cp\u003eReliable light scattering measurement require the samples to be degassed and filtered. The Calypso incorporates built-in, low-volume degassers and filter housings, connected via PEEK tubing and finger-tight fittings. Even the filter housing is finger-tight, making use of a proprietary design for maximum convenience.\u003c\/p\u003e\n\u003cp\u003eCalypso features\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBiocompatible wetted materials.\u003c\/li\u003e\n\u003cli\u003eFlexibility to re-organize fluid paths and utilize different wetted materials as needed.\u003c\/li\u003e\n\u003cli\u003eConvenient loading of sample and diluent solutions via conical tubes: 5, 15 or 50 mL.\u003c\/li\u003e\n\u003cli\u003eAutoinject Out contact closure signal, to trigger data acquisition by \u003ca href=\"https:\/\/www.wyatt.com\/products\/software\/astra.html\"\u003eASTRA\u003csup\u003e™\u003c\/sup\u003e\u003c\/a\u003e or \u003ca href=\"https:\/\/www.wyatt.com\/products\/software\/dynamics.html\"\u003eDYNAMICS\u003csup\u003e™\u003c\/sup\u003e\u003c\/a\u003e software for data acquisition and analyses not supported by the CALYPSO software (e.g., DLS acquisition).\u003c\/li\u003e\n\u003cli\u003eBuilt-in Wash port, allowing the pumps to draw on reservoirs of wash solutions for post-experimental clean-up. Automation of up to two sequential wash solutions, e.g. buffer (to clean out proteins) followed by water (to clean out buffer salts) or detergent followed by water, is possible when an \u003ca href=\"https:\/\/store.wyatt.com\/shop\/eclipse\/dualtec-o\/orbit\/\"\u003eOrbit\u003csup\u003e™\u003c\/sup\u003e solvent selector valve\u003c\/a\u003e is added to the setup. These operations are appended to the Method for unattended operation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"column one-second\"\u003e\n\u003c!--[video_embed video=\"\" parameters=\"\" mp4=\"https:\/\/www.labtube.tv\/videos\/720p\/151907-720.mp4\" ogv=\"\" placeholder=\"\" width=\"400\" height=\"215\"]  \t\n\n          \u003cp\u003e\u003cb\u003ePlay video to learn more about the Calypso system\u003c\/b\u003e\u003c\/p\u003e\n  \t\t\u003cp\u003e\n           \n      \u003c\/p\u003e\t--\u003e\n\u003cimg align=\"right\" alt=\"Calypso Experimental Setup\" height=\"399px\" src=\"https:\/\/www.wyatt.com\/wp-content\/uploads\/2019\/05\/Calypso-DAWN-Optilab-Neon-System.jpg\" style=\"margin: 15px\" width=\"400px\"\u003e\n\u003c\/div\u003e\n\u003ch2\u003eSpecifications\u003c\/h2\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSyringe Pumps\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e3 computer-controlled pumps; dc-servo motor, for minimum pulsation; 3-port distribution valve on each pump for Input, Output and Wash\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSyringe Volumes\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e12.5 µL to 2.5 mL (1 mL and 0.5 mL syringes supplied as standard)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDegasser Channels\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e1 per pump, 60 µL internal volume\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003ePressure Limit\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e1 mL syringes: 200 psi 0.5 mL syringes: 400 psi\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eAuxiliary Inputs\/Outputs\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eAutoinject out, injector valve control, recycle valve control, digital and analog I\/O for specific applications\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSolvents\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eAqueous\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eWetted Materials\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eBorosilicate glass, PEEK, PTFE, polyethylene, alumina, titanium, stainless steel\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eTypical Sample Volume Per Analysis\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e2.5 to 7 mL, depending on detector configuration and complexity of analysis\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eRange of Measurement\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eEquilibrium Dissociation Constant, K D : 100 pM to 1 mM typical for 100 kDa molecules (actual range varies with molecular weight and association stoichiometry)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eRepeatability of Measurement\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eM w : ± 5% A 2 : ± 0.5 x 10 mol·mL\/g² for sample molar mass of 50 to 100 kDa log( K D ): ± 0.3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSpecific Binding\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eSee CALYPSO Software for more details. Self-association Hetero-association Multi-valent Combined self- and hetero-association incompetent (inactive) fraction Cooperativity and competitive binding Binding with thermodynamic non-ideality (high concentration) Concatenate multiple data sets for global fit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eNon-Specific Interactions\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eSelf-interaction: 2 and 3 virial coefficients Hetero-interactions: cross virial coefficients with 2 self-virial coefficients\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eKinetics\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e1 -order analyzed in software; export data for higher-order kinetics\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eAdditional analyses\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003edn\/dc\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eHost PC Requirements\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eUSB port for Calypso Ethernet connection for DAWN \/ miniDAWN communications\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDimensions\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e58 cm (L) x 37 cm (W) x 35 cm (H)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.wyatt.com\/products\/calypso-brochure-request.html\" target=\"_blank\"\u003eBrochure\u003c\/a\u003e\u003c\/p\u003e","brand":"Wyatt Technology","offers":[{"title":"Default Title","offer_id":46488399020111,"sku":"WCG3","price":0.0,"currency_code":"ILS","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/files\/Calypso.jpg?v=1787675387"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0712\/0748\/5519\/collections\/DAWN-Hero-Neon-9-19_ec09b7e7-d1cb-4312-92a5-e60c5d7ceefb.jpg?v=1790860119","url":"https:\/\/www.danyel.co.il\/collections\/mals.oembed","provider":"danyel biotech","version":"1.0","type":"link"}